Zobrazeno 1 - 10
of 39
pro vyhledávání: '"RI Freudenthal"'
Publikováno v:
Pharmacological Research Communications. 6:457-468
The effects of ethynodiol diacetate norethindtone and norethynodrel on the hepatic microsomal drug metabolizing enzyme system of rat were studied. 10 or 50 mg norethynodren/kg or 50 mg norethindrone/kg markedly increased the duration of pentobarital-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872555f7d49b3fd5c41f22d5c041505d
https://doi.org/10.1016/s0031-6989(74)80055-x
https://doi.org/10.1016/s0031-6989(74)80055-x
Publikováno v:
Analytical Biochemistry. 51:632-636
A method has been developed for the preparation of a high specific activity stereospecifically labeled tritiated NADPH. In this procedure, tritium is enzymatically transferred from d-isocitric acid-2-3H (8 Ci/mmole) to the A face of a pyridine nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbfd49bfda8feb0045231929ce55cc6
https://doi.org/10.1016/0003-2697(73)90518-6
https://doi.org/10.1016/0003-2697(73)90518-6
Publikováno v:
Toxicology and Applied Pharmacology. 24:125-132
In vitro norethynodrel was found to rapidly metabolize to norethindrone the 3-alpha- and 3 beta-hydroxy metabolites and an unknown complex. From these intermediaries biosynthesis continues to more polar polyhydroxylated products whose hydroxyl positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ea7b509b8683e09f12c4cd6a1e8028
https://doi.org/10.1016/0041-008x(73)90187-7
https://doi.org/10.1016/0041-008x(73)90187-7
Publikováno v:
British Journal of Pharmacology. 44:244-249
1. The distribution of Delta(9)-tetrahydrocannabinol-(14)C in the pregnant and nonpregnant mouse is very similar. High concentrations of radiolabel can be seen in the maternal liver, spleen, lungs, brown fat, adrenal glands, mammary glands, yolk sac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546d2bcf31d04e32533e9b55b9fcfc4b
https://doi.org/10.1111/j.1476-5381.1972.tb07260.x
https://doi.org/10.1111/j.1476-5381.1972.tb07260.x
Publikováno v:
Biochemical Pharmacology. 20:1507-1512
The incubation in vitro of norethynodrel with the postmitochondrial supernatant from rat liver results in the formation of three intermediary metabolites, namely the 3α- and 3β-hydroxy derivatives and norethindrone. These three steroids are further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16b923bb63d58d4bf29887e9acb722d
https://doi.org/10.1016/0006-2952(71)90279-6
https://doi.org/10.1016/0006-2952(71)90279-6
Autor:
JT Gidley, RI Freudenthal, Dolores R. Brine, L Testino, Monroe E. Wall, Roni Rosenfeld, HD Christensen, C Pitt, G Boegli
Publikováno v:
Science (New York, N.Y.). 172(3979)
The 11-hydroxy metabolites of Delta(8).- and Delta(9)-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Delta(8)- and Delta(9)-tetrahydrocannabinol are rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361939ebf6d4599430eda048c4d18cf5
https://pubmed.ncbi.nlm.nih.gov/5547729
https://pubmed.ncbi.nlm.nih.gov/5547729
Publikováno v:
International journal of toxicology [Int J Toxicol] 2001 Sep-Oct; Vol. 20 (5), pp. 269-74.
Autor:
Freudenthal RI, Anderson DP
Publikováno v:
Journal of the National Cancer Institute [J Natl Cancer Inst] 1997 May 21; Vol. 89 (10), pp. 734; author reply 735-6.
Autor:
Freudenthal RI; First Chemical Corporation, Pascagoula, Mississippi 39568, USA., Anderson DP
Publikováno v:
Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 1995 Feb; Vol. 21 (1), pp. 199-202; discussion 203-5.
Autor:
Freudenthal RI, Anderson DP
Publikováno v:
Journal of the National Cancer Institute [J Natl Cancer Inst] 1994 Jan 05; Vol. 86 (1), pp. 59-62.