Zobrazeno 1 - 10
of 1 015
pro vyhledávání: '"REPEAT KINASE 2"'
Autor:
Dong Hwan Ho, Hyejung Kim, Daleum Nam, Mi Kyoung Seo, Sung Woo Park, Dong-Kyu Kim, Ilhong Son
Publikováno v:
NeuroSci, Vol 5, Iss 3, Pp 301-314 (2024)
Leucine-rich repeat kinase 2 (LRRK2) and α-synuclein are involved in the pathogenesis of Parkinson’s disease. The activity of LRRK2 in microglial cells is associated with neuroinflammation, and LRRK2 inhibitors are crucial for alleviating this neu
Externí odkaz:
https://doaj.org/article/e3d6090638ef442b8c176a26ff976812
Autor:
Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche, Sibel Ertan, Peter Bauer, Arndt Rolfs, Soraya Hezzaz, Jenny Ghelfi, Norbert Brüggemann, Paul Antony, Paul Wilmes, Christine Klein, Anne Grünewald, Emma L. Schymanski
Publikováno v:
Environment International, Vol 194, Iss , Pp 109151- (2024)
Pathogenic variants in the Leucine-rich repeat kinase 2 (LRRK2) gene are a primary monogenic cause of Parkinson’s disease (PD). However, the likelihood of developing PD with inherited LRRK2 pathogenic variants differs (a phenomenon known as “redu
Externí odkaz:
https://doaj.org/article/53b2fdfaecd24a82a16ac492dfe9127c
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 5, Pp 4324-4336 (2024)
Astrocytes in the brain contribute to various essential functions, including maintenance of the neuronal framework, survival, communication, metabolic processes, and neurotransmitter levels. Leucine-rich repeat kinase 2 (LRRK2) is associated with the
Externí odkaz:
https://doaj.org/article/486c66daa0e54dc99c091cb975b46bdb
Autor:
Linlin Gao, Rahul Gaurav, Pia Ziegner, Jinghong Ma, Junyan Sun, Jie Chen, Jiliang Fang, Yangyang Fan, Yan Bao, Dongling Zhang, Piu Chan, Qi Yang, Zhaoyang Fan, Stéphane Lehéricy, Tao Wu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Asymptomatic Leucine-Rich Repeat Kinase 2 Gene (LRRK2) carriers are at risk for developing Parkinson's disease (PD). We studied presymptomatic substantia nigra pars compacta (SNc) regional neurodegeneration in asymptomatic LRRK2 carriers com
Externí odkaz:
https://doaj.org/article/c7aeaf61ac2247a584f5f24b59d9a325
Autor:
Neda M. Ilieva, Eric K. Hoffman, Mohammed A. Ghalib, J. Timothy Greenamyre, Briana R. De Miranda
Publikováno v:
Neurobiology of Disease, Vol 196, Iss , Pp 106522- (2024)
Idiopathic Parkinson's disease (PD) is epidemiologically linked with exposure to toxicants such as pesticides and solvents, which comprise a wide array of chemicals that pollute our environment. While most are structurally distinct, a common cellular
Externí odkaz:
https://doaj.org/article/a92ed5ed1b54404a8a38e89a2172c19a
Autor:
Laura Cucinotta, Deborah Mannino, Alessia Filippone, Adele Romano, Emanuela Esposito, Irene Paterniti
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Recent studies have demonstrated dysregulation of the autophagy pathway in patients with Parkinson’s disease (PD) and in animal models of PD, highlighting its emerging role in disease. In particular, several studies indicate that autophagy, which i
Externí odkaz:
https://doaj.org/article/90759260df85492492fc9c48bf689ca0
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionIntrapancreatic activation of trypsinogen caused by alcohol or high-fat intake and the subsequent autodigestion of the pancreas tissues by trypsin are indispensable events in the development of acute pancreatitis. In addition to this tryp
Externí odkaz:
https://doaj.org/article/24ef6beff67a4778acd49e35c63afb3a
Autor:
Sung Won LEE, Sangwook PARK
Publikováno v:
Korean Journal of Clinical Laboratory Science, Vol 55, Iss 2, Pp 105-112 (2023)
Leucine-rich repeat kinase 2 (LRRK2) is known to play a crucial role in the pathophysiology of neurodegenerative disorders such as Parkinson’s disease. LRRK2 is predominantly expressed in the lung as well as the brain. However, it is unclear whethe
Externí odkaz:
https://doaj.org/article/75d3b3140ad7490cbef188234e9f5930
Autor:
Neil Donison, Matthew Hintermayer, Maegha Subramaniam, Erin Santandrea, Kathryn Volkening, Michael J. Strong
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Phosphorylated microtubule-associated protein tau (tau) aggregates are a pathological hallmark of various neurodegenerative diseases, including chronic traumatic encephalopathy and amyotrophic lateral sclerosis with cognitive impairment. While there
Externí odkaz:
https://doaj.org/article/2299cbd01d6043df929240c2af22b231
Autor:
Shun Zhang, Subo Qian, Hailong Liu, Ding Xu, Weimin Xia, Huangqi Duan, Chen Wang, Shenggen Yu, Yingying Chen, Ping Ji, Shujun Wang, Xingang Cui, Ying Wang, Haibo Shen
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102860- (2023)
Mitochondrial dysfunction is one of the key features of acute kidney injury (AKI) and associated fibrosis. Leucine-rich repeat kinase 2 (LRRK2) is highly expressed in kidneys and regulates mitochondrial homeostasis. How it functions in AKI is unclear
Externí odkaz:
https://doaj.org/article/81de6354001a4e85a49d274828e8f2ab