Zobrazeno 1 - 10
of 1 246
pro vyhledávání: '"RELATED SUBSTANCES"'
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
BackgroundPonatinib, a third-generation tyrosine kinase inhibitor, is employed in the management of adult chronic myeloid leukemia. Nevertheless, the presence of process impurities and degradation impurities linked to ponatinib may potentially influe
Externí odkaz:
https://doaj.org/article/fd2fc9fdd70e4169906222d2312a64ae
Publikováno v:
Zaštita Materijala, Vol 65, Iss 2, Pp 191-201 (2024)
The analysis of improved RP-HPLC method for the separation and quantification of Gatifloxacin and its impurities are described. Samples are analysed by means of reverse phase (RP-HPLC) using an Zorbax Eclipse C18, 50 x 4.6 mm5µm and the mobile phase
Externí odkaz:
https://doaj.org/article/c5423aa1a2f14ef5b842b3ca38954065
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
BackgroundPralsetinib, a targeted inhibitor of the RET enzyme, plays a critical role in the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) characterized by RET gene fusion mutations following platin
Externí odkaz:
https://doaj.org/article/ec59d74c594745539af85e2d0d132644
Publikováno v:
Pharmaceutical Fronts, Vol 06, Iss 02, Pp e183-e191 (2024)
Externí odkaz:
https://doaj.org/article/bdce6146307e4499ada7012e48e39feb
Autor:
Jing Yao, Xuejia Zhao, Yifei Jiang, Limin Zuo, Xiaodan Qiu, Xiaofang Lian, Huiyi Liu, Qingying Jia, Huimin Sun, Guangzhi Shan
Publikováno v:
Separations, Vol 11, Iss 8, p 223 (2024)
To determine the paclitaxel-related substances in a paclitaxel injection (albumin-bound), it is necessary to remove human blood albumin from the sample via solid-phase extraction and subsequently perform high-performance liquid chromatography analysi
Externí odkaz:
https://doaj.org/article/4bc197dc5734456b92c537bb9e3f8140
Autor:
O. A. Vaganova, A. A. Natykan
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 3, Pp 473-480 (2023)
This article provides recommendations for documenting an analytical procedure for the determination of related substances by high-performance liquid chromatography in a product specification file (PSF). The article contains a description of specific
Externí odkaz:
https://doaj.org/article/7789422150b747579bc1336006ca9a0a
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 2-1, Pp 271-282 (2023)
Chromatographic methods for the analysis of antibiotic degradation products are widely used to evaluate the quality of medicines. Natural multicomponent antibiotics, such as capreomycin, are the most challenging compounds in terms of developing analy
Externí odkaz:
https://doaj.org/article/c637ceed99af40f28ae645144f4ea319
Autor:
Pengyan Zhu, Xiaojing Shen, Xinting Wang, Xinlan Liu, Yingshuang Zhang, Ke Wang, Wenfen Gao, Xuanjun Wang, Wenjuan Yuan
Publikováno v:
Molecules, Vol 29, Iss 3, p 588 (2024)
In total, three related substances (RS) associated with sotalol hydrochloride (STHCl) were herein identified with a novel gradient high-performance liquid chromatography (HPLC) protocol. Further characterization of these substances was then performed
Externí odkaz:
https://doaj.org/article/d91b7c72ace94abfb5876c3580ee006b
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Publikováno v:
Heliyon, Vol 9, Iss 5, Pp e15732- (2023)
Lamotrigine extended release tablet dosage form LAMICTAL XR used as an anticonvulsant in the treatment of generalized tonic clonic, absence seizures and partial seizures. The objective of the present study is to develop and validate analytical method
Externí odkaz:
https://doaj.org/article/743cd0f95d1c4e5cb09249b7b2df01b1