Zobrazeno 1 - 10
of 17
pro vyhledávání: '"REGINALD GORCZYNSKI"'
Autor:
Aaron Prodeus, Amanda Sparkes, Nicholas W. Fischer, Marzena Cydzik, Eric Huang, Ismat Khatri, Ashley Young, Lindsay Woo, Chung Wai Chow, Reginald Gorczynski, Jean Gariépy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 350-358 (2018)
Functional aptamers displaying agonistic or antagonistic properties are showing great promise as modulators of immune responses. Here, we report the development of a polyethylene glycol-modified (PEGylated) DNA aptamer as a cross-species (murine and
Externí odkaz:
https://doaj.org/article/5750cf03cd144d82bdfd43700068f42a
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171586 (2017)
Cell-surface CD200 expression by mouse EMT6 breast tumor cells increased primary tumor growth and metastasis to the draining lymph nodes (DLN) in normal (WT) BALB/c female recipients, while lack of CD200R1 expression in a CD200R1-/- host negated this
Externí odkaz:
https://doaj.org/article/0da5972b40d140d39ca5329a9618d050
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0146681 (2016)
CD200:CD200 receptor (CD200R) interactions lead to potent immunosuppression and inhibition of autoimmune inflammation. We investigated the effect of "knockout"of CD200 or CD200R, or over-expression of CD200, on susceptibility to dextran sodium sulfat
Externí odkaz:
https://doaj.org/article/51352a472c7e410a91ff64046ac7f339
Autor:
Aaron Prodeus, Marzena Cydzik, Aws Abdul-Wahid, Eric Huang, Ismat Khatri, Reginald Gorczynski, Jean Gariépy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
CD200R1 expressed on the surface of myeloid and lymphoid cells delivers immune inhibitory signals to modulate inflammation when engaged with its ligand CD200. Signalling through CD200/CD200R1 has been implicated in a number of immune-related diseases
Externí odkaz:
https://doaj.org/article/bd86da66c202420296ac8ee713d6add6
Autor:
Reginald Gorczynski
Publikováno v:
Internal Medicine Review. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::657f19f5edbc6658fc13762fc7d1f254
https://doi.org/10.18103/imr.v2i10.258
https://doi.org/10.18103/imr.v2i10.258
Autor:
Syed S. Islam, Katherine Moore, Yasir Loai, Reginald Gorczynski, Herman Yeger, Walid A. Farhat, Sevan Evren, Roula Antoon, Karrie Wong
Publikováno v:
Cells Tissues Organs. 192:250-261
Introduction: Natural scaffolds have been shown to induce T helper 2 (TH2)-specific immune responses in host tissues; however, the precise mechanisms that underlie this immune response are unknown. Using a porcine animal model, we evaluated the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0909c285147daa9a42af6f64c9961a
https://doi.org/10.1159/000317332
https://doi.org/10.1159/000317332
Autor:
Jean Gariepy, Ismat Khatri, Reginald Gorczynski, Ashley Young, Lindsay Woo, Chung-Wai Chow, Marzena Cydzik, Aaron Prodeus
Publikováno v:
The Journal of Immunology. 198:194.24-194.24
Functional aptamers displaying agonistic or antagonistic properties are showing great promise in terms of modulating immune responses. Our group has recently developed pegylated DNA aptamers that can either block inflammatory responses (CD200R1agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d6028a90b14ff9256f9ec54c7d7f46a
https://doi.org/10.4049/jimmunol.198.supp.194.24
https://doi.org/10.4049/jimmunol.198.supp.194.24
Autor:
JASBIR S. SANDHU, REGINALD GORCZYNSKI, BARUCH SHPITZ, STEVEN GALLINGER, HAI-PHU NGUYEN, NOBUMICHI HOZUMI
Publikováno v:
Transplantation. 60(2)
Despite previous attempts there is currently no suitable animal model available for xenogeneic graft versus host disease (XGVHD) mediated via human immunocompetent cells. Recently, we have developed an efficient protocol to engraft SCID mice with hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f18687b5daa9d2fe2bd7b0e33e20f6
https://pubmed.ncbi.nlm.nih.gov/7624960
https://pubmed.ncbi.nlm.nih.gov/7624960
Publikováno v:
The Journal of Immunology. 186:169.8-169.8
CD200, a molecule of the immunoglobulin supergene family, increases graft survival and suppresses inflammation/acquired immunity after binding to its receptors (CD200Rs). Skin and cardiac allograft survival is increased in transgenic mice over-expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff03c7660be06e0ddcd770aa4ab1ea46
https://doi.org/10.4049/jimmunol.186.supp.169.8
https://doi.org/10.4049/jimmunol.186.supp.169.8