Zobrazeno 1 - 10 of 322 pro vyhledávání: '"RE Gay"'
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OP0326 Epigenetically-driven distal expression of the lncrna hottip shapes inflammatory, adhesive and proliferative characteristics of hand synovial fibroblasts in arthritis
Autor: M Frank Bertoncelj, E Karouzakis, K Klein, A Bratus, C Kolling, O Distler, A Filer, RE Gay, CD Buckley, S Gay, C Ospelt
Publikováno v: Oral Presentations.
Background Rheumatoid arthritis (RA) and other types of inflammatory arthritis show a characteristic pattern of joint involvement. E.g. in RA there is a predilection for the small joints of hands and feet, whereas in spondyloarthropathy, single large
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a66ffe2965082d39cafc94e95162f369
https://doi.org/10.1136/annrheumdis-2017-eular.2689
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A3.09 Synovial fibroblasts as determinants for arthritis specific pattern of joint involvement
Autor: M Frank-Bertoncelj, K Klein, G Russo, A Bratus, E Karouzakis, C Kolling, A Filer, CD Buckley, RE Gay, S Gay, C Ospelt
Publikováno v: Annals of the Rheumatic Diseases. 75:A35.3-A36
Background and objectives Most forms of arthritis occur with a distinctive pattern of joint involvement. To elucidate whether stromal differences between the joints might play a role in the susceptibility of joints to develop arthritis, we compared t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::601c0734b3200ca665e9d96b686ef8d5
https://doi.org/10.1136/annrheumdis-2016-209124.86
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Dual inhibition of 5-lipoxygenase and cyclooxygenases 1 and 2 by ML3000 reduces joint destruction in adjuvant arthritis
Autor: Re, Gay, Michel Neidhart, Pataky F, Tries S, Laufer S, Gay S
Publikováno v: Europe PubMed Central
To search for potential new therapies to inhibit the progression of joint destruction in patients with rheumatoid arthritis.We evaluated the dual acting antiinflammatory drug ML3000 (2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro- H-pyrrolizine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0285cbc00d5f51947e77dbb5e336098b
https://pubmed.ncbi.nlm.nih.gov/11550975
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OP0040 Bucillamine and its metabolites induce synthesis of vegf dose dependently in systemic sclerosis fibroblasts via the nf-kb pathway
Autor: C Hagen, O Distler, U Müller-Ladner, A Carossino, RE Gay, R Nanagara, BA Michel, K Nishioka, M Matucci-Cerinic, S Gay
Publikováno v: Speaker abstracts 2001.
Background Bucillamine (BUC) is an immunomodulatory drug used in the treatment of rheumatoid arthritis with inhibitory effects on B- and T-cell functions. However, the impact of Bucillamine on metabolic pathways of fibroblasts has not been addressed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5742e5131ebe9d58905997a740f046b6
https://doi.org/10.1136/annrheumdis-2001.297
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AB0206 Investigation of the inducibility of retroviruses from rheumatoid arthritis synovial fibroblasts (ra-sf) and ra-synovial fluid cells (ra-sfc)
Autor: CA Seemayer, SA Kolb, J Böni, M Neidhart, B Simmen, RE Gay, BA Michel, J Schüpbach, S Gay
Publikováno v: Speaker abstracts 2001.
Background Objectives In many investigations virus like particles (VLP) and especially type-C retroviruses could be activated from tumour cells in culture after stimulation with DNA damaging agents. Co-culture with H9 cells, a lymphatic cell line, ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::786651cb3347e683e912cf3c32deb808
https://doi.org/10.1136/annrheumdis-2001.717
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THU0092 The l1 mrna in rheumatoid arthritis encodes a functional retrotransposable element
Autor: M Neidhart, J Rethage, O Distler, MT Peyer, ME Billingham, BA Michel, RE Gay, S Gay
Publikováno v: Speaker abstracts 2001.
Background L1 retrotransposons have been detected in rheumatoid arthritis (RA) at sites of joint destruction. Objectives To caracterise the L1 mRNA in RA. Methods RNA was isolated from the synovial tissue of a 35-years old woman with RA. The complete
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4013794cd74459a94a3d125251baa5f
https://doi.org/10.1136/annrheumdis-2001.969
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THU0097 The discrepancy between mrna and protein expression of the tumour-suppressor gene maspin in synovial tissue might contribute to synovial hyperplasia in rheumatoid arthritis (ra)
Autor: J Schedel, E Jeisy Walder, B Simmen, BA Michel, RE Gay, S Gay
Publikováno v: Speaker abstracts 2001.
Background RA is a chronic disease characterised by tumour-like features such as synovial hyperplasia, invasive growth of the synovium and joint destruction. Maspin is a member of the serpin family of protease inhibitors with gene sequence similariti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c126015752847633962dfe4f40359f2
https://doi.org/10.1136/annrheumdis-2001.974
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THU0109 The destructive process of rheumatoid arthritis synovial fibroblasts (ra-sf) is independent of p53
Autor: CA Seemayer, S Kuchen, M Neihart, P Kuenzler, E Neumann, M Pruschy, T Pap, WK Aicher, U Muller-Ladner, BA Michel, RE Gay, S Gay
Publikováno v: Speaker abstracts 2001.
Background Objectives The aim of this study was to investigate, whether the destructive process of synovial fibroblasts in rheumatoid arthritis is dependent on the expression of p53. Moreover, we searched for the expression of p53 in RA-SF in vitro a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8194f7e2ee23af9144f92e6bafb2a86c
https://doi.org/10.1136/annrheumdis-2001.986
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