A re-examination of the SPYRAL HTN-OFF MED Pivotal trial with respect to the underlying model assumptions

Autor: David E. Kandzari, Graeme L. Hickey, Sandeep Brar, Stuart J. Pocock, Vanessa DeBruin, Felix Mahfoud, Michael Böhm, Martin Fahy, Michael A. Weber

Publikováno v: Contemporary Clinical Trials Communications
Contemporary Clinical Trials Communications, Vol 23, Iss, Pp 100818-(2021)

Background The SPYRAL HTN-OFF MED Pivotal trial demonstrated that RDN was efficacious compared to a sham control. The underlying model was an extension of the analysis of covariance (ANCOVA) model, adjusted for baseline blood pressure (BP), and allow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb87fdc08eb72b00b3533267e39749e
https://pubmed.ncbi.nlm.nih.gov/34258470

Renal denervation attenuates hypertension and renal dysfunction in a model of cardiovascular and renal disease, which is associated with reduced NADPH and xanthine oxidase activity

Autor: Peleli, Maria, Flacker, Peter, Zhuge, Zhengbing, Gomez, Cristina, Wheelock, Craig E., Persson, Erik, Carlstrom, Mattias

Publikováno v: Redox Biology
Redox Biology, Vol 13, Iss C, Pp 522-527 (2017)

Oxidative stress is considered a central pathophysiological event in cardiovascular disease, including hypertension. Early age reduction in renal mass is associated with hypertension and oxidative stress in later life, which is aggravated by increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4ef61b0bbe95793377ac3879e9cfa216
https://pubmed.ncbi.nlm.nih.gov/28734244

Validation of a Novel Renal Denervation System With Cryoablation: A Preclinical Study and Case Series.

Autor: Ji M; Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China.; Shanghai Institute of Cardiovascular Diseases, Shanghai, China., Chen H; Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China.; Shanghai Institute of Cardiovascular Diseases, Shanghai, China., Shen L; Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China.; Shanghai Institute of Cardiovascular Diseases, Shanghai, China., Zhang Y; Shanghai Tenth People's Hospital, Shanghai, China., Yao Z; Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China.; Shanghai Institute of Cardiovascular Diseases, Shanghai, China., Wu Y; Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China.; Shanghai Institute of Cardiovascular Diseases, Shanghai, China., Xu Y; Shanghai Tenth People's Hospital, Shanghai, China., Ge J; Department of Cardiology, Zhongshan Hospital, Fudan University, Research Unit of Cardiovascular Techniques and Devices, Chinese Academy of Medical Sciences, Shanghai, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China.; Shanghai Institute of Cardiovascular Diseases, Shanghai, China.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2022 Feb 02; Vol. 7 (2), pp. 101-112. Date of Electronic Publication: 2022 Feb 02 (Print Publication: 2022).

A re-examination of the SPYRAL HTN-OFF MED Pivotal trial with respect to the underlying model assumptions.

Autor: Böhm M; Saarland University Hospital, Geb. 41, Kirrberger Strasse 1, 66421, Homburg (Saar), Germany., Fahy M; Medtronic PLC, 3576 Unocal Place, Santa Rosa, CA, 95403, USA., Hickey GL; Medtronic PLC, 3576 Unocal Place, Santa Rosa, CA, 95403, USA., Pocock S; London School of Hygiene and Tropical Medicine, Keppel Street, Bloomsbury, London, WC1E 7HT, UK., Brar S; Medtronic PLC, 3576 Unocal Place, Santa Rosa, CA, 95403, USA., DeBruin V; Medtronic PLC, 3576 Unocal Place, Santa Rosa, CA, 95403, USA., Weber MA; SUNY Downstate College of Medicine, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA., Mahfoud F; Saarland University Hospital, Geb. 41, Kirrberger Strasse 1, 66421, Homburg (Saar), Germany., Kandzari DE; Piedmont Heart Institute, 95 Collier Road NW, Atlanta, GA, 30309, USA.

Publikováno v: Contemporary clinical trials communications [Contemp Clin Trials Commun] 2021 Jun 29; Vol. 23, pp. 100818. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).

Renal Denervation Decreases Susceptibility to Arrhythmogenic Cardiac Alternans and Ventricular Arrhythmia in a Rat Model of Post-Myocardial Infarction Heart Failure.

Autor: Chang SN; Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan., Chang SH; Division of Cardiology, Department of Internal Medicine, Camillians Saint Mary's Hospital Luodong, Luodong, Taiwan., Yu CC; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Wu CK; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lai LP; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Chiang FT; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Hwang JJ; Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lin JL; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Tsai CT; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Publikováno v: JACC. Basic to translational science [JACC Basic Transl Sci] 2017 Apr 24; Vol. 2 (2), pp. 184-193. Date of Electronic Publication: 2017 Apr 24 (Print Publication: 2017).