The photochemistry of α-nitrostilbenes and related compounds. A study of double bond cleavage following intramolecular cyclization and nitro-nitrite rearrangement

Autor: RD Grant, JT Pinhey, E Rizzardo

Publikováno v: Australian Journal of Chemistry. 37:1217

A detailed study of the photochemistry of a number of α-nitrostilbenes is reported. The previously described intramolecular cyclization of (1) which resulted in cleavage of the double bond was not found to occur to any extent in the other compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc18f50c09e5b721b4d9b0592635edbd
https://doi.org/10.1071/ch9841217

The Photochemistry of α,Β-Unsaturated Nitro Compounds and Nitronic Acids. Concerning Deconjugation and α,Β-Unsaturated Ketone Formation

Autor: GC Smith, E. Rizzardo, RD Grant, JT Pinhey

Publikováno v: Australian Journal of Chemistry. 38:1505

The photochemistry of cyclohexylidenenitromethane (6), 3-ethyl-2-nitropent-2-ene (7), (Z)-α-methyl-α- nitrostilbene (12), (E)-3-methyl- 1-nitro-1-phenylbut-1-ene (15) and 4,4-dimethyl-3-nitro-5α-cholest-2- ene (27) has been examined to determine t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0f702cc8033698947d94ed9fb5b8ef4
https://doi.org/10.1071/ch9851505

A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.

Autor: Chitty JL; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia., Yam M; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Perryman L; Pharmaxis, Frenchs Forest, New South Wales, Australia., Parker AL; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia., Skhinas JN; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Setargew YFI; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Mok ETY; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Tran E; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Grant RD; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Latham SL; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Pereira BA; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Ritchie SC; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Murphy KJ; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Trpceski M; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Findlay AD; Pharmaxis, Frenchs Forest, New South Wales, Australia., Melenec P; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Filipe EC; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia., Nadalini A; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Velayuthar S; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Major G; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Wyllie K; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Papanicolaou M; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Ratnaseelan S; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Phillips PA; School of Biomedical Sciences, Faculty of Medicine, Lowy Cancer Research Centre, UNSW Sydney, Sydney, New South Wales, Australia., Sharbeen G; School of Biomedical Sciences, Faculty of Medicine, Lowy Cancer Research Centre, UNSW Sydney, Sydney, New South Wales, Australia., Youkhana J; School of Biomedical Sciences, Faculty of Medicine, Lowy Cancer Research Centre, UNSW Sydney, Sydney, New South Wales, Australia., Russo A; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Blackwell A; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Hastings JF; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Lucas MC; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Chambers CR; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Reed DA; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Stoehr J; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Vennin C; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Pidsley R; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Zaratzian A; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Da Silva AM; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Tayao M; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Charlton B; Pharmaxis, Frenchs Forest, New South Wales, Australia., Herrmann D; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia., Nobis M; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.; Intravital Imaging Expertise Center, VIB Center for Cancer Biology, VIB, Leuven, Belgium., Clark SJ; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Biankin AV; Wolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK.; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK., Johns AL; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Croucher DR; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Nagrial A; Department of Medical Oncology, Westmead Hospital, Sydney, New South Wales, Australia., Gill AJ; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.; Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, New South Wales, Australia.; Cancer Diagnosis and Pathology Research Group, Kolling Institute of Medical Research, Sydney, New South Wales, Australia., Grimmond SM; University of Melbourne Centre for Cancer Research, VCCC, Melbourne, Victoria, Australia., Pajic M; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia.; The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia., Timpson P; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia., Jarolimek W; Pharmaxis, Frenchs Forest, New South Wales, Australia. wolfgang.jarolimek@pharmaxis.com.au., Cox TR; Cancer Ecosystems Program, The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia. t.cox@garvan.org.au.; School of Clinical Medicine, St Vincent's Healthcare Clinical Campus, UNSW Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia. t.cox@garvan.org.au.

Publikováno v: Nature cancer [Nat Cancer] 2023 Sep; Vol. 4 (9), pp. 1326-1344. Date of Electronic Publication: 2023 Aug 28.

The Mini-Organo: A rapid high-throughput 3D coculture organotypic assay for oncology screening and drug development.

Autor: Chitty JL; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, NSW, Australia., Skhinas JN; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia., Filipe EC; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, NSW, Australia., Wang S; Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University, Lund, Sweden., Cupello CR; Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University, Lund, Sweden., Grant RD; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia., Yam M; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia., Papanicolaou M; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.; School of Life Sciences, University of Technology Sydney, Sydney, Australia., Major G; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia., Zaratzian A; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia., Da Silva AM; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia., Tayao M; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia., Vennin C; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.; Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Timpson P; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, NSW, Australia., Madsen CD; Department of Laboratory Medicine, Division of Translational Cancer Research, Lund University, Lund, Sweden., Cox TR; The Garvan Institute of Medical Research and the Kinghorn Cancer Centre, Sydney, NSW, Australia.; St Vincent's Clinical School, Faculty of Medicine, UNSW, Sydney, NSW, Australia.

Publikováno v: Cancer reports (Hoboken, N.J.) [Cancer Rep (Hoboken)] 2020 Feb; Vol. 3 (1), pp. e1209. Date of Electronic Publication: 2019 Aug 01.