Phytoconstituents from ten natural herbs as potent inhibitors of main protease enzyme of SARS-COV-2: in silico study

Autor: Kavita Bhagat, Preet Mohinder Singh Bedi, Atamjit Singh, Amit Duggal, Puja Gulati, Komalpreet Kaur, Shilpa Dudhal, Harmandeep Kaur Gulati, Jatinder Vir Singh, Jaspreet Kaur, Harbinder Singh, Nitish Kumar

Publikováno v: Phytomedicine Plus
Phytomedicine Plus, Vol 1, Iss 4, Pp 100083-(2021)

Background Lack of treatment of novel Coronavirus disease led to the search of specific antivirals that are capable to inhibit the replication of the virus. The plant kingdom has demonstrated to be an important source of new molecules with antiviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939ef681815567886f1f3e386c85714b
http://europepmc.org/articles/PMC8180089

Identification of phytochemicals as potential therapeutic agents that binds to Nsp15 protein target of coronavirus (SARS-CoV-2) that are capable of inhibiting virus replication

Autor: Suman Chowdhury, Priya Kashyap, Suresh Kumar, Anil Panwar, Ashok Kumar, Shivani Kumar

Publikováno v: Phytomedicine

Highlights • Sarsasapogenin, ursonic acid, ajmalicine, novobiocin, silymarin and aranotin are strongly binding to Nsp15 target using autodock software. • Curcumin, piperine, gingerol, rosmarinic acid, ursolic acid and alpha terpinyl acetate show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962e95ce19b1a43f2031508fec35f172
https://pubmed.ncbi.nlm.nih.gov/32943302

A comprehensive immunoinformatics and target site study revealed the corner-stone toward Chikungunya virus treatment

Autor: Amit Datta, Md. Arif Khan, Md. Habibul Hasan Mazumder, Md. Anayet Hasan, Mohammad Uzzal Hossain

Publikováno v: Molecular Immunology

Highlights • Epitope-based vaccine design facilitates laboratory research and save valuable time and money. • Immunoinformatics tools were used to predict B and T-cell epitopes within the E2 protein. • Highest population coverage was recorded 8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdaa8a81b271fd06420b016e3fc1f17
https://doi.org/10.1016/j.molimm.2014.12.013

Phytoconstituents from ten natural herbs as potent inhibitors of main protease enzyme of SARS-COV-2: In silico study.

Autor: Kumar N; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005.; Drug and Pollution testing Lab, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Singh A; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Gulati HK; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Bhagat K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Kaur K; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Kaur J; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Dudhal S; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Duggal A; Drugs Control Wing, Sector 16, Chandigarh, India, 160015., Gulati P; School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India, 147301., Singh H; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Singh JV; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India, 143005., Bedi PMS; Drug and Pollution testing Lab, Guru Nanak Dev University, Amritsar, Punjab, India, 143005.

Publikováno v: Phytomedicine plus : international journal of phytotherapy and phytopharmacology [Phytomed Plus] 2021 Nov; Vol. 1 (4), pp. 100083. Date of Electronic Publication: 2021 Jun 06.