Long-Term Transplant Effects of iPSC-RPE Monolayer in Immunodeficient RCS Rats

Autor: Deepthi S. Rajendran Nair, Danhong Zhu, Ruchi Sharma, Juan Carlos Martinez Camarillo, Kapil Bharti, David R. Hinton, Mark S. Humayun, Biju B. Thomas

Publikováno v: Cells, Vol 10, Iss 11, p 2951 (2021)

Retinal pigment epithelium (RPE) replacement therapy is evolving as a feasible approach to treat age-related macular degeneration (AMD). In many preclinical studies, RPE cells are transplanted as a cell suspension into immunosuppressed animal eyes an

Externí odkaz: https://doaj.org/article/0be3be12448847bb9cacd7559b8922c4

Untersuchung der elektrophysiologischen Eigenschaften retinaler Ganglienzellen in der degenerierten Rattennetzhaut

Autor: Hesse, Stephan

Publikováno v: Aachen : RWTH Aachen University 1 Online-Ressource : Illustrationen (2021). doi:10.18154/RWTH-2021-05727 = Dissertation, RWTH Aachen University, 2021

Dissertation, RWTH Aachen University, 2021; Aachen : RWTH Aachen University 1 Online-Ressource : Illustrationen (2021). = Dissertation, RWTH Aachen University, 2021
The present paper examines the influence of photoreceptor degeneration on signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5943c01c972ef1be2571e06f3b98448e
https://publications.rwth-aachen.de/record/820611

Identification of novel genes and altered signaling pathways in the retinal pigment epithelium during the Royal College of Surgeons rat retinal degeneration

Autor: Eric M Dufour, Emeline Nandrot, Dominique Marchant, Loïc Van Den Berghe, Stéphanie Gadin, Moussa Issilame, Jean-Louis Dufier, Cécile Marsac, Deborah Carper, Maurice Menasche, Marc Abitbol

Publikováno v: Neurobiology of Disease, Vol 14, Iss 2, Pp 166-180 (2003)

Shed photoreceptor outer segments (POS) are phagocytosed by RPE cells in a circadian manner. The homozygous deletion of the c-mer gene abolishes the ingestion phase of this phagocytosis in the Royal College of Surgeons (RCS) rat strain, which in turn

Externí odkaz: https://doaj.org/article/22bfd756c8a343619d23562edd127bc1

Cell therapy with hiPSC-derived RPE cells and RPCs prevents visual function loss in a rat model of retinal degeneration

Autor: Anna Veiga, Barbara Ferreira-de-Souza, Anna Duarri, Helena Isla-Magrané, Diana Mora Ramírez, Miguel A Zapata, José García-Arumí, Laura Fontrodona, Angel Raya, Anna Badia, Anna Salas

Publikováno v: Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Molecular Therapy. Methods & Clinical Development
Dipòsit Digital de la UB
Universidad de Barcelona
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 688-702 (2021)

Photoreceptor loss is the principal cause of blindness in retinal degenerative diseases (RDDs). Whereas some therapies exist for early stages of RDDs, no effective treatment is currently available for later stages, and once photoreceptors are lost, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7207e634aae6fa9795d6cffd8e160728
https://hdl.handle.net/11351/6539

Degeneration of Rat Retina is Paralleled by an Imbalance of the Redox Mechanism of Pteridines

Autor: Cremer-Bartels Gertrud

Publikováno v: Pteridines, Vol 7, Iss 4, Pp 137-142 (1996)

The RCS rat suffers from a genetic degeneration of retinal cell We have examined the pattern of oxidized and reduced monapterin and biopterin in retinas from RCS retinas and controls. The ratio of oxidized monapterin to reduced monapterin was signifi

Externí odkaz: https://doaj.org/article/3c5675606f444a3a8d4952564ced41b1