Systemic Administration of Parathyroid Hormone-Related Peptide (PTHrP) 1-36 Enhances β-Cell Proliferation and Increases β-Cell Mass in Adult Mice

Autor: KR Williams, DK Abanquah, SJ Gokhale, H Lin, NK Guthalu, XY Zhang, A Bisello, AF Stewart, A Garcia-Ocana, RC Vasavada

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b936b28022122479062489975c12e3e
https://doi.org/10.1210/endo-meetings.2010.part3.p10.p3-479

RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes.

Autor: Kondegowda NG; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Filipowska J; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Do JS; Department of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA., Leon-Rivera N; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA., Li R; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hampton R; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ogyaadu S; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Levister C; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Penninger JM; IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna 1030, Austria.; Department of Medical Genetics, Life Sciences Institute, University of British Columbia, Vancouver, Canada., Reijonen H; Department of Immunology and Theranostics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA., Levy CJ; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Endocrinology and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Vasavada RC; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.; Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Publikováno v: Science advances [Sci Adv] 2023 Nov 03; Vol. 9 (44), pp. eadf5238. Date of Electronic Publication: 2023 Nov 01.

LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation.

Autor: Filipowska J; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute City of Hope, Duarte, CA, United States., Kondegowda NG; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute City of Hope, Duarte, CA, United States., Leon-Rivera N; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute City of Hope, Duarte, CA, United States., Dhawan S; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute City of Hope, Duarte, CA, United States., Vasavada RC; Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute City of Hope, Duarte, CA, United States.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 May 30; Vol. 13, pp. 867001. Date of Electronic Publication: 2022 May 30 (Print Publication: 2022).

CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats.

Autor: Sacaan AI; Pfizer Inc. San Diego, California. rupangi.vasavada@mssm.edu aida.sacaan@pfizer.com., Thibault S; Pfizer Inc. San Diego, California., Hong M; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Kondegowda NG; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Nichols T; Pfizer Inc. San Diego, California., Li R; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Rosselot C; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Evering W; Pfizer Inc. San Diego, California., Fenutria R; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Vitsky A; Pfizer Inc. San Diego, California., Brown T; Pfizer Inc., Groton, Connecticut., Finkelstein M; Pfizer Inc., Pearl River, New York., Garcia-Ocaña A; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Khan N; Pfizer Inc., Groton, Connecticut., Stewart AF; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Vasavada RC; Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, New York. rupangi.vasavada@mssm.edu aida.sacaan@pfizer.com.

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2017 Nov; Vol. 15 (11), pp. 1531-1541. Date of Electronic Publication: 2017 Jul 31.

PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2.

Autor: Lakshmipathi J; Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Alvarez-Perez JC; Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Rosselot C; Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Casinelli GP; Division of Pediatric Hematology/Oncology and Blood and Marrow Transplantation, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA., Stamateris RE; Department of Medicine, University of Massachusetts Medical School, Worcester, MA., Rausell-Palamos F; Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., O'Donnell CP; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA., Vasavada RC; Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Scott DK; Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Alonso LC; Department of Medicine, University of Massachusetts Medical School, Worcester, MA., Garcia-Ocaña A; Diabetes, Obesity and Metabolism Institute, Division of Endocrinology, Diabetes and Bone Diseases, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY adolfo.g.ocana@mssm.edu.

Publikováno v: Diabetes [Diabetes] 2016 May; Vol. 65 (5), pp. 1283-96. Date of Electronic Publication: 2016 Feb 11.