Zobrazeno 1 - 10
of 44
pro vyhledávání: '"RBV, ribavirin"'
Akademický článek
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Autor:
Hao Zhang, Junqi Niu, Jingmin Zhao, Xiumei Chi, Shuhong Liu, Na Li, Boan Li, Huiying Rao, Gaungde Zhou, Yijin Wang, Liyuan Wu, Hongyang Liu, Lai Wei
Publikováno v:
EBioMedicine
Background Whether achieving sustained virological response (SVR) in patients with hepatitis C attains complete elimination of hepatitis C virus (HCV) is unknown, because occult HCV infection (OCI), defined as the detection of HCV-RNA in hepatocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95d08a454f667aa82197c3d29644d49
http://europepmc.org/articles/PMC6711338
http://europepmc.org/articles/PMC6711338
Autor:
Radha K. Dhiman, Ajay Duseja, Akash Roy, Sunil Taneja, Mmphcrf Investigators, Madhumita Premkumar, Sanjeev Arora, Gagandeep Singh Grover
Publikováno v:
EClinicalMedicine
EClinicalMedicine, Vol 41, Iss, Pp 101148-(2021)
EClinicalMedicine, Vol 41, Iss, Pp 101148-(2021)
Background The prevalence of chronic hepatitis C (CHC) in People Who Inject Drugs (PWID) is 8-10% as compared to 3·6% in the general population in Punjab, India. We assessed the real-world efficacy and safety of free-of-charge generic direct-acting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75aae0e46392eeae5fc474b6ba1cdf3
https://pubmed.ncbi.nlm.nih.gov/34712928
https://pubmed.ncbi.nlm.nih.gov/34712928
Autor:
Heather Bailey, Claire Thorne, Antons Mozalevskis, Po-Lin Chan, Intira Jeannie Collins, Farihah Malik, Philippa Easterbrook
Publikováno v:
JHEP Reports
JHEP Reports, Vol 3, Iss 2, Pp 100227-(2021)
JHEP Reports, Vol 3, Iss 2, Pp 100227-(2021)
Summary Background & Aims It is estimated that 3.26 million children and adolescents worldwide have chronic HCV infection. To date, the global response has focused on the adult population, but direct-acting antiviral (DAA) regimens are now approved f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85a8f0fd496be783ec59396327859dc
https://pubmed.ncbi.nlm.nih.gov/33665586
https://pubmed.ncbi.nlm.nih.gov/33665586
Autor:
Tetsu Endo, Kouji Joko, Hiroyuki Marusawa, Jun Itakura, Chikara Ogawa, Shuichi Wada, Keisuke Amano, Masashi Mizokami, Masayuki Kurosaki, Takehiro Akahane, Youhei Koushima, Namiki Izumi, Nobuaki Nakayama, Satoru Kakizaki, Chitomi Hasebe, Jun Inoue, Tatsuya Kanto
Publikováno v:
JHEP Reports
JHEP Reports, Vol 2, Iss 5, Pp 100138-(2020)
JHEP Reports, Vol 2, Iss 5, Pp 100138-(2020)
Background & Aims We aimed to clarify the features of resistance-associated substitutions (RASs) after failure of multiple interferon (IFN)-free regimens in HCV genotype 1b infections. Methods A total of 1,193 patients with HCV for whom direct-acting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3131da698f06bb64e9f397d13b87c0b
https://pubmed.ncbi.nlm.nih.gov/32817930
https://pubmed.ncbi.nlm.nih.gov/32817930
Autor:
Eleanor Barnes, Michelle Cheung, John McLauchlan, William L. Irving, Wing-Yiu Jason Lee, David A. Smith, M. Azim Ansari, Connor G. G. Bamford, Meleri Jones, Sampath DaSilva, Peter A.C. Wing, Elihu Aranday-Cortes, Graham R. Foster, Morven Cunningham, Ana da Silva Filipe
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Sofosbuvir is a frequently used pan-genotype inhibitor of hepatitis C virus (HCV) polymerase. This drug eliminates most chronic HCV infections and resistance-associated substitutions in the polymerase are rare. However, HCV genotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15381bbbe0a38344b99de9f3ac715c3a
https://ora.ox.ac.uk/objects/uuid:416feebd-d673-4614-9eb1-08d83c47f8f6
https://ora.ox.ac.uk/objects/uuid:416feebd-d673-4614-9eb1-08d83c47f8f6
Autor:
Selwyn J. Hurwitz, Guofeng Chen, Gregory Cheng, Raymond F. Schinazi, Yudong Wang, Dong Ji, Qing Shao, Mingjie Zhang, Cheng Wang, George Lau, Vanessa Wu, Xiao-Xia Niu
Publikováno v:
Metabolism Open
Metabolism Open, Vol 10, Iss, Pp 100090-(2021)
Metabolism Open, Vol 10, Iss, Pp 100090-(2021)
Background and aim The incidence of hepatocellular carcinoma (HCC) decreases significantly in chronic hepatitis C (CHC) patients with sustained virologic response (SVR) after pegylated-interferon plus ribavirin (PR) or direct-acting antiviral (DAAs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4a650b4b0e3d9e33548b1fb63073cb
https://doi.org/10.1016/j.metop.2021.100090
https://doi.org/10.1016/j.metop.2021.100090
Autor:
Dengke Tian, Liang Xin, Minge Wan, Xie Xiaolin, Zhang Dezhu, Wenqiang Cao, Liang Chengyuan, Liu Yuzhi, Li Han, Hong Liu, Xueqi Fu
Publikováno v:
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111313-(2021)
Graphical abstract
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a760af616f0938c4e771824446939551
http://europepmc.org/articles/PMC7857046
http://europepmc.org/articles/PMC7857046
Publikováno v:
Virus Research, 234, 58-73
Virus Research
Virus Research
Highlights • Nidoviral RNA signals and protein co-factors control RdRp processivity and fidelity. • The RdRp directs a complex process of replication and subgenomic mRNA synthesis. • A unique N-terminal nucleotidyl transferase is connected to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f03c18d2c9c41509c1f43138ecc53a7
https://hdl.handle.net/1887/114569
https://hdl.handle.net/1887/114569
Autor:
Guangdi Li, Erik De Clercq
Publikováno v:
Antiviral Research
One of the most exciting developments in antiviral research has been the discovery of the direct-acting antivirals (DAAs) that effectively cure chronic hepatitis C virus (HCV) infections. Based on more than 100 clinical trials and real-world studies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0d0080d68b869f8b81c6d078e11707
https://pubmed.ncbi.nlm.nih.gov/28238877
https://pubmed.ncbi.nlm.nih.gov/28238877