Zobrazeno 1 - 10
of 25 519
pro vyhledávání: '"RATIONAL DESIGN"'
Autor:
Brianda L. Santini, Margrethe Gaardløs, Dariusz Wyrzykowski, Sven Rothemund, Anja Penk, Martin Zacharias, Sergey A. Samsonov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2985-2994 (2024)
Cyclic peptides present a robust platform for drug design, offering high specificity and stability due to their conformationally constrained structures. In this study, we introduce an updated version of the Cyclic Peptide Matching program (cPEPmatch)
Externí odkaz:
https://doaj.org/article/35f5e31773204f40aabdbcb950c9b903
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 7691-7708 (2024)
Xun Zhou,1,2,* Jingzhou Liu,2,* Shuang Xiao,2,3,* Xiaoqing Liang,1,2 Yi Li,2 Fengzhen Mo,3 Xin Xin,2 Yang Yang,2 Chunsheng Gao1,2 1School of Pharmacy, Henan University, Kaifeng, People’s Republic of China; 2State Key Laboratory of Toxic
Externí odkaz:
https://doaj.org/article/58c2fe22206644798bb3b5c759c63da4
Improving the enzymatic activity and stability of N-carbamoyl hydrolase using deep learning approach
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Optically active D-amino acids are widely used as intermediates in the synthesis of antibiotics, insecticides, and peptide hormones. Currently, the two-enzyme cascade reaction is the most efficient way to produce D-amino acids usi
Externí odkaz:
https://doaj.org/article/25d9821add1743d9b9465d483877987f
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Enzymatic therapy with nicotine-degrading enzyme is a new strategy in treating nicotine addiction, which can reduce nicotine concentrations and weaken withdrawal in the rat model. However, when O2 is used as the electron acceptor, no satisfa
Externí odkaz:
https://doaj.org/article/2a29fb20129b4fffb5dc38deb1f11c87
Autor:
Lei Nie, Carolina Muñoz-Camargo, Sayan Ganguly, Lahoucine Bahsis, Juan C. Cruz, Reza Mohammadinejad, Aldo Nicosia, Luis H. Reyes, Xing Wang
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/5a42e4e104aa46d1b213d8c624174cfd
Publikováno v:
International Journal for Computational Civil and Structural Engineering, Vol 20, Iss 3 (2024)
The article deals with the problem of rational design of a nonlinearly deformable heterogeneous composite Timoshenko rod under force impact. The rod has a structure that is symmetrical relative to the force plane, formed by the connection of quasi-ho
Externí odkaz:
https://doaj.org/article/9f7fb1697e4c4e3b92fb2374409af916
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The protein tyrosine phosphatase 1B (PTP1B) is a critical therapeutic target for type 2 diabetes mellitus (T2DM). Many PTP1B inhibitors have been reported, however, most of them lack high specificity and have adverse effects. Designing effective PTP1
Externí odkaz:
https://doaj.org/article/d2f46cf4c1064482b593c54ae6ebdf24
Autor:
Mia Radović, Ana Jurinjak Tušek, Tamara Reiter, Wolfgang Kroutil, Marina Cvjetko Bubalo, Ivana Radojčić Redovniković
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Stabilized enzymes are crucial for the industrial application of biocatalysis due to their enhanced operational stability, which leads to prolonged enzyme activity, cost-efficiency and consequently scalability of biocatalytic processes. Over the past
Externí odkaz:
https://doaj.org/article/1e1ecf6a8fa840d4a253636144daa7ad
Publikováno v:
Food Innovation and Advances, Vol 3, Iss 2, Pp 191-201 (2024)
Carboxypeptidase A(CPA) has a great potential application in the food and pharmaceutical industry due to its capability to hydrolyze ochratoxin A(OTA) and remove the bitterness of peptide. However, CPA is a mesophilic enzyme that cannot adequately ex
Externí odkaz:
https://doaj.org/article/4a5af5742abb442780a5f4bb896173cc
Publikováno v:
Nano Biomedicine and Engineering, Vol 16, Iss 1, Pp 28-47 (2024)
In the past decade, nanozymes - a unique class of nanomaterials with inherent enzyme-mimetic properties - have fascinated researchers, revealing unexpected enzyme-like activity of nanomaterials previously considered biologically inert. In particular,
Externí odkaz:
https://doaj.org/article/b3b3ae505fff4404969a1fda85ba31a3