Zobrazeno 1 - 10
of 673
pro vyhledávání: '"RAS PATHWAY"'
Autor:
Bo Han, Daqing Cheng, Huizhao Luo, Jutang Li, Jiaoxiang Wu, Xing Jia, Ming Xu, Peng Sun, Sheng Cheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Hepatocellular carcinoma (HCC) still presents poor prognosis with low overall survival rates and limited therapeutic options available. Recently, attention has been drawn to peptidomic analysis, an emerging field of proteomics for the explor
Externí odkaz:
https://doaj.org/article/0a5117f129784fa2a27f313308fbb634
Autor:
Katherine A. Rauen, William E. Tidyman
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/6482ac10005546bb8f0801ed14b9c1a4
Autor:
Dan Song, Ke An, Wenlong Zhai, Luyao Feng, Yingjie Xu, Ran Sun, Yueqin Wang, Yun-Gui Yang, Quancheng Kan, Xin Tian
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 4, Pp 823-833 (2023)
RNA modifications affect many biological processes and physiological diseases. The 5-methylcytosine (m5C) modification regulates the progression of multiple tumors. However, its characteristics and functions in hepatocellular carcinoma (HCC) remain l
Externí odkaz:
https://doaj.org/article/56fff26e24f14c52b0bb951aea7d4c51
Autor:
M.G. Mirisola, V.D. Longo
Publikováno v:
Biomedical Journal, Vol 47, Iss 2, Pp 100694- (2024)
In Saccharomyces cerevisiae, RAt Sarcoma (Ras) activity plays a central role in mediating the effect of glucose in decreasing stress resistance and longevity, with constitutive Ras activation mutations promoting cell growth and oncogenesis. Here, we
Externí odkaz:
https://doaj.org/article/0ef6b59e1de848cc90a4f282a723fefd
Publikováno v:
Clinical Epidemiology and Global Health, Vol 26, Iss , Pp 101535- (2024)
Background: Lead (Pb), a ubiquitous environmental toxin linked with various illnesses, including hypertension (HTN). Though preclinical models have proposed various mechanisms, few epidemiological studies explored the operative pathway(s) demonstrati
Externí odkaz:
https://doaj.org/article/94c1af5a547b4960907a4b67da77edfd
Autor:
Jianting Gong, Yingwei Zhao, Xiantao Heng, Yongbing Chen, Pingping Sun, Fei He, Zhiqiang Ma, Zilin Ren
Publikováno v:
Electronic Research Archive, Vol 31, Iss 8, Pp 4951-4967 (2023)
The goal of precision oncology is to select more effective treatments or beneficial drugs for patients. The transcription of ‘‘hidden responders’’ which precision oncology often fails to identify for patients is important for revealing respon
Externí odkaz:
https://doaj.org/article/217ac5d1d97e4b95abb2b0fbb1033881
Autor:
Ruifang Zheng, Franklin Fuda, Jeffrey R. Gagan, Olga K. Weinberg, Prasad Koduru, Miguel Cantu, Kathleen Ludwig, Jamie M. Truscott, Robert Collins, Stephen Chung, Yazan F. Madanat, Weina Chen
Publikováno v:
Leukemia Research Reports, Vol 21, Iss , Pp 100410- (2024)
B/T mixed phenotype acute leukemia (MPAL) is a rare aggressive leukemia. Three cases of B/T MPAL were identified with comprehensive immunophenotypic, cytogenetic, and molecular studies. T-lineage predominant B/T MPAL shares a genetic signature with T
Externí odkaz:
https://doaj.org/article/29321a2d531d4336987fdcd870ed2b8c
Autor:
A. Marshall, K. F. Kommoss, H. Ortmann, M. Kirchner, J. Jauckus, P. Sinn, T. Strowitzki, A. Germeyer
Publikováno v:
Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-11 (2023)
Abstract Background The pathogenesis of deep infiltrating endometriosis (DIE) is poorly understood. It is considered a benign disease but has histologic features of malignancy, such as local invasion or gene mutations. Moreover, it is not clear wheth
Externí odkaz:
https://doaj.org/article/ef063e9eabd6484d9311cb1aec98b256
Autor:
Nihad Ashraf Khan, Deena Elsori, Gowhar Rashid, Sonia Tamanna, Ananya Chakraborty, Adeeba Farooqi, Ayman Kar, Niti Sambyal, Mohammad Azhar Kamal
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Endometrial cancer (EC), the most common adenocarcinoma, represents 90% of uterine cancer in women with an increased incidence of occurrence attributed to age, obesity, hypertension, and hypoestrogenism. Being the most common gynecological malignancy
Externí odkaz:
https://doaj.org/article/d246f05c5dbf455eb40e79b199cdc2b9
Autor:
Marco Prato, Natalia Tiberti, Cristina Mazzi, Federico Gobbi, Chiara Piubelli, Silvia Stefania Longoni
Publikováno v:
Microorganisms, Vol 12, Iss 3, p 583 (2024)
The RAS is a hormonal system playing a pivotal role in the control of blood pressure and electrolyte homeostasis, the alteration of which is associated with different pathologies, including acute respiratory distress syndrome (ARDS). As such, it is n
Externí odkaz:
https://doaj.org/article/109857004b2a46609d0d87604854457b