Zobrazeno 1 - 1
of 1
pro vyhledávání: '"RARalpha2"'
Autor:
Gianmaria Borleri, Gabriela Paroni, Alessandro Rambaldi, Maurizio Gianni, Mami Kurosaki, Adriana Zanetti, Maddalena Fratelli, Marco Bolis, Enrico Garattini, Cécile Rochette-Egly, Mineko Terao
Publikováno v:
Oncotarget
Oncotarget, 2017, 8 (23), pp.37041-37060. ⟨10.18632/oncotarget.10556⟩
Oncotarget, 2017, 8 (23), pp.37041-37060. ⟨10.18632/oncotarget.10556⟩
Treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) is the first example of targeted therapy. In fact, the oncogenic fusion-protein (PML-RAR) typical of this leukemia contains the retinoid-nuclear-receptor RARalpha. PM