Zobrazeno 1 - 10
of 246
pro vyhledávání: '"RAR-related orphan receptor alpha"'
Autor:
Hong Soon Kang, Anton M. Jetten, Kevin Gerrish, Amir Aghajanian, Ju Youn Beak, Brian C. Jensen, Seok Jae Hong, Wei Huang, Rishi Deshmukh, Nishi Kadakia
Publikováno v:
The Journal of Biological Chemistry
Preserving optimal mitochondrial function is critical in the heart, which is the most ATP-avid organ in the body. Recently, we showed that global deficiency of the nuclear receptor RORα in the "staggerer" mouse exacerbates angiotensin II-induced car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cc243bde3123b1ebf3e9dc15c170f2
http://europepmc.org/articles/PMC8626585
http://europepmc.org/articles/PMC8626585
Autor:
Qingfeng Chen, Yong Fan, Yue Zhao, Thiam Chye Tan, Xue Ying Chan, Kenneth Tou En Chang, Sue Yee Tan, Sharrada Subramaniam, Min Liu, Eva Loh
Publikováno v:
Blood. 130:1995-2005
Many immune parameters show circadian rhythms during the 24-hour day in mammals. The most striking circadian oscillation is the number of circulating immune cells that display an opposite rhythm between humans and mice. The physiological roles and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bb23db46506a5fb906df711365eae4
https://doi.org/10.1182/blood-2017-04-778779
https://doi.org/10.1182/blood-2017-04-778779
Autor:
Makoto Akashi, Ritsuko Matsumura
Publikováno v:
Journal of Biological Chemistry. 292:16081-16092
Cell-autonomous oscillation in clock gene expression drives circadian rhythms. The development of comprehensive analytical techniques, such as bioinformatics and ChIP-sequencing, has enabled the genome-wide identification of potential circadian trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac3b765366350756e29d11736c5a39d9
https://doi.org/10.1074/jbc.m117.806836
https://doi.org/10.1074/jbc.m117.806836
Autor:
Ping Li, Haifang Wang, Parth Devesh Joshi, Yichi Xu, Meng Zhao, Zhihu Zhao, Zenghua Fan, Weimin Guo, Yan Zhang, Jun Yan
Publikováno v:
Nucleic Acids Research
Circadian rhythm exerts its influence on animal physiology and behavior by regulating gene expression at various levels. Here we systematically explored circadian long non-coding RNAs (lncRNAs) in mouse liver and examined their circadian regulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61790b9cefd65410b474a6be3ee2f5ce
https://doi.org/10.1093/nar/gkx156
https://doi.org/10.1093/nar/gkx156
Autor:
Breanne C. Wilhite, Sophie Haven, Joseph A. Schultz, Chi-Hsiu Liu, Jing Chen, Joseph R. Hibbeln, Chuck T. Chen
Publikováno v:
Prostaglandins, leukotrienes, and essential fatty acids. 152
Deficiency in retinoid acid receptor-related orphan receptor alpha (RORα) of staggerer mice results in extensive granule and Purkinje cell loss in the cerebellum as well as in learned motor deficits, cognition impairments and perseverative tendencie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8644d9aa4c849672721d39987155701
https://pubmed.ncbi.nlm.nih.gov/31835092
https://pubmed.ncbi.nlm.nih.gov/31835092
Autor:
Tingting Cai, Bingxuan Hua, Gongsheng Yuan, Ruizhe Qian, Ning Sun, Zuoqin Yan, Chao Lu, Yang Yang, Lirong Xu
Publikováno v:
Journal of Bone and Mineral Research. 32:861-871
The expression patterns of clock-controlled genes (ccgs) are regulated by circadian rhythm, which is a major regulatory and physiological mechanism tied to the solar day. Disruptions in circadian rhythm contribute to the development of cardiovascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a620e8715d9cef6089e56dc661ba6e39
https://doi.org/10.1002/jbmr.3046
https://doi.org/10.1002/jbmr.3046
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 708-719 (2016)
Cell Reports
Cell Reports
Summary Circadian clocks generate 24-hr rhythms in physiology and behavior. Despite numerous studies, it is still uncertain how circadian rhythms emerge from their molecular and neural constituents. Here, we demonstrate a tight connection between the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dca13af5950ee166accb8622cf8772b
http://www.sciencedirect.com/science/article/pii/S2211124716312876
http://www.sciencedirect.com/science/article/pii/S2211124716312876
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 80:1131-1140
The circadian rhythm generated by circadian clock underlies a molecular mechanism of rhythmic transcriptional regulation by transcription factor BMAL1/CLOCK. Importantly, the circadian clock is coordinated by exogenous cues to accommodate to changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc382470ac1a87bbb87df14f87af1b15
https://doi.org/10.1080/09168451.2015.1136885
https://doi.org/10.1080/09168451.2015.1136885
Autor:
Joshua J. Gooley
Publikováno v:
Proceedings of the Nutrition Society. 75:440-450
The circadian system temporally coordinates daily rhythms in feeding behaviour and energy metabolism. The objective of the present paper is to review the mechanisms that underlie circadian regulation of lipid metabolic pathways. Circadian rhythms in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e62e2f903498bf44f3c23ea7818b35a
https://doi.org/10.1017/s0029665116000288
https://doi.org/10.1017/s0029665116000288
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859:541-552
Cell proliferation in mammals follows a circadian rhythm while disruption of clock gene expression has been linked to tumorigenesis. Expression of the c-Myc oncogene is frequently deregulated in tumors, facilitating aberrant cell proliferation. c-MYC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56e01154a3692b0787c8db9e46cf218
https://doi.org/10.1016/j.bbagrm.2016.02.001
https://doi.org/10.1016/j.bbagrm.2016.02.001