Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents

Autor: André Luiz Lourenço, Charles S. Craik, Leonardo A. Silva, Max Seidy Saito, Alessandra Mendonça Teles de Souza, Maria A.F. Vera, Juliana da Fonseca Rezende e Mello, Raquel R.S. Salvador, Estela M.F. Muri, Plínio Cunha Sathler, Lucio Mendes Cabral, Helena Carla Castro, Carlos Rangel Rodrigues, Luiza R.S. Dias

Publikováno v: European journal of medicinal chemistry. 135

Cardiovascular diseases (CVDs) account for over 17 million deaths globally each year, with atherosclerosis as the underlying cause of most CVDs. Herein we describe the synthesis and in vitro mechanistic evaluation of novel N'-benzylidene-carbohydrazi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deaf33d59adad352227f4fed3d0268dd
https://pubmed.ncbi.nlm.nih.gov/28453995

New carbohydrazide derivatives of 1H-pyrazolo[3,4-b]pyridine and trypanocidal activity

Autor: Luiza R.S. Dias, Sérgio de Albuquerque, Murilo Lamim Bello, Igor Ramon Lomba Barreto, Raquel R.S. Salvador, Estela M.F. Muri, Maria A.F. Vera

Publikováno v: Anais da Academia Brasileira de Ciências, Iss 0
Anais da Academia Brasileira de Ciências, Volume: 88, Issue: 4, Pages: 2341-2348, Published: 01 DEC 2016
Anais da Academia Brasileira de Ciências v.88 n.4 2016
Anais da Academia Brasileira de Ciências
Academia Brasileira de Ciências (ABC)
instacron:ABC

This paper reports the in vitro trypanocidal activity evaluation of new carbohydrazide derivatives from 3-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine, substituted at C-6 position by phenyl, methyl or trifluoromethyl group. These compounds were evaluat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d1d7dc1cfc40aa4ff9b5ec13a4c3b9
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016005020105&lng=en&tlng=en