Discovery of Potential Candidate Genes for Coat Colour in Wuzhishan Pigs by Integrating SNPs and mRNA Expression Analysis

Autor: Qiao Xu, Yabiao Luo, Zhe Chao, Jibin Zhang, Xiaolei Liu, Danqin Tu, Qin Guo, Ruiping Sun, Feng Wang, Meiying Fang

Publikováno v: Animals, Vol 14, Iss 23, p 3493 (2024)

Despite identifying genes regulating the coat colour in Western pig breeds, the genetic basis of the coat colour in Chinese indigenous pigs is still not understood due to the diversity of indigenous breeds and their genetic differences from exotic pi

Externí odkaz: https://doaj.org/article/f0689648188b4aedba20847d96b18a8f

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Autor: Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E. Bilasy, Tsuyoshi Miyakawa, Tohru Kataoka

Publikováno v: Molecular Brain, Vol 11, Iss 1, Pp 1-22 (2018)

Abstract Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain. Previous genomic analyses suggested their possible involvement in the eti

Externí odkaz: https://doaj.org/article/a0f39571e86346cdbd6e09f99519d52c

Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration

Autor: Tohru Kataoka, Akihiko Nishikimi, Yasuyuki Momoi, Koko Katagiri, Guangwei Du

Publikováno v: Biochemical and Biophysical Research Communications. 524:325-331

Integrin activation by Rap1-GTP is pivotal for lymphocyte trafficking. In this study, we show the phosphatidic acid (PA)-dependent membrane distribution of RA-GEF-1 and -2 (also known as Rapgef2 and 6), which are guanine nucleotide exchange factors f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005a412be3a682c1535049d6058492bd
https://doi.org/10.1016/j.bbrc.2020.01.080

Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2

Autor: Charles L. Sawyers, Bingbing Zhu, Agnieszka Bierzynska, Madhav C. Menon, Shazia Ashraf, Jianhua Li, Aili Cao, Friedhelm Hildebrandt, Vivette D. D'Agati, Jenny Wong, Moin A. Saleem, Wen Peng, Steven Hou, Lewis Kaufman, Kirk N. Campbell, John Cijiang He, James J. Young

Publikováno v: Zhu, B, Cao, A, Li, J, Ashraf, S, Bierzynska, A, Menon, M C, Hou, S, Sawyers, C, Campbell, K N, Saleem, M A, He, J C, Hildebrandt, F, D'Agati, V D & Kaufman, L 2019, ' Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2 ', Kidney International, vol. 96, no. 3, pp. 642-655 . https://doi.org/10.1016/j.kint.2019.03.016

The essential role of membrane associated guanylate kinase 2 (MAGI2) in podocytes is indicated by the phenotypes of severe glomerulosclerosis of both MAGI2 knockout mice and in patients with congenital nephrotic syndrome (CNS) caused by mutations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d3e6993b651acd6619e8539b2af897
https://doi.org/10.1016/j.kint.2019.03.016

Cyclic AMP‐dependent Activation of ERK Via GLP‐1 Receptor Signaling Requires the Neuroendocrine Cell‐Selective Guanine Nucleotide Exchanger NCS‐RapGEF2

Autor: George G. Holz, Lee E. Eiden, Oleg G. Chepurny, Andrew C. Emery, Sam P. Dahlke, Wenqin Xu

Publikováno v: The FASEB Journal. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0799684bad9f16065280bced7ba5fd58
https://doi.org/10.1096/fasebj.2021.35.s1.04803