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pro vyhledávání: '"RAPA, rapamycin"'
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Autor:
Andras Perl, Christian Geier
Publikováno v:
Autoimmunity Reviews
The mechanistic target of rapamycin (mTOR) pathway integrates metabolic cues into cell fate decisions. A particularly fateful event during the adaptive immune response is the engagement of a T cell receptor by its cognate antigen presented by an anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3990d80b30d059d40d16ba75850ac283
https://pubmed.ncbi.nlm.nih.gov/34718162
https://pubmed.ncbi.nlm.nih.gov/34718162
Autor:
Boris Görg, Hans-Jürgen Bidmon, Barbara Biermann, Dieter Häussinger, Andreas S. Reichert, Nikolaj Klöcker, Marcel Zimmermann, Kaihui Lu
Publikováno v:
EBioMedicine, Vol 48, Iss, Pp 539-553 (2019)
EBioMedicine
EBioMedicine
Background: Hepatic encephalopathy (HE) is a severe neuropsychiatric syndrome caused by various types of liver failure resulting in hyperammonemia-induced dysfunction of astrocytes. It is unclear whether autophagy, an important pro-survival pathway,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464436083ac4c4e9e420c1a64df0fc74
http://www.sciencedirect.com/science/article/pii/S2352396419306401
http://www.sciencedirect.com/science/article/pii/S2352396419306401
Autor:
Sebastian Mueller, Shijin Wang, Vanessa Rausch, Linna Yu, Johannes Mueller, Cheng Chen, Franco Fortunato
Publikováno v:
Redox Biology
Redox Biology, Vol 46, Iss, Pp 102081-(2021)
Redox Biology, Vol 46, Iss, Pp 102081-(2021)
Background Alcoholic liver disease (ALD) is the most common liver disease worldwide and its underlying molecular mechanisms are still poorly understood. Moreover, conflicting data have been reported on potentially protective autophagy, the exact role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::936d61c25a5f24c36b5bf0af348b8c2f
http://europepmc.org/articles/PMC8350071
http://europepmc.org/articles/PMC8350071
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 9, Iss, Pp 192-198 (2018)
Molecular Metabolism, Vol 9, Iss, Pp 192-198 (2018)
Objective Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed ‘browning’), has great therapeutic potential to treat obesity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf4c6e369f9bb0a2692c57390c55d70
http://europepmc.org/articles/PMC5870104
http://europepmc.org/articles/PMC5870104
Publikováno v:
Redox Biology
Redox Biology, Vol 12, Iss, Pp 150-161 (2017)
Redox Biology, Vol 12, Iss, Pp 150-161 (2017)
There is an unmet need for novel metal-based chemotherapeutics with alternative modes of action compared to clinical agents such as cisplatin and metallo-bleomycin. Recent attention in this field has focused on designing intracellular ROS-mediators a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e67aea8bdb5ae2837e6d49fe842adc
Autor:
Elisabeth Sehn, Christian Behl, Christof Hiebel, Franz H. Grus, Vanessa Felzen, Uwe Wolfrum, Caroline Manicam, Natarajan Perumal, Debapriya Chakraborty, Elisabeth Stürner
Publikováno v:
Redox Biology
Redox Biology, Vol 24, Iss, Pp-(2019)
Redox Biology, Vol 24, Iss, Pp-(2019)
Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the most important hallmarks of aging and of neurodegenerative disorders. The proteasomal and autophagic-lysosomal degradation pathways are key measures to maintai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc330b09215555a3158f06dbb32cb3
http://europepmc.org/articles/PMC6454062
http://europepmc.org/articles/PMC6454062
Autor:
Baranyi, Ulrike, Farkas, Andreas M., Hock, Karin, Mahr, Benedikt, Linhart, Birgit, Gattringer, Martina, Focke-Tejkl, Margit, Petersen, Arnd, Wrba, Fritz, Rülicke, Thomas, Valenta, Rudolf, Wekerle, Thomas
Publikováno v:
EBioMedicine
EBioMedicine, Vol 7, Iss C, Pp 230-239 (2016)
EBioMedicine, Vol 7, Iss C, Pp 230-239 (2016)
Background Therapeutic strategies for the prophylaxis of IgE-mediated allergy remain an unmet medical need. Cell therapy is an emerging approach with high potential for preventing and treating immunological diseases. We aimed to develop a cell-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1cff621a3dd57452f02889e4e632776e
http://europepmc.org/articles/PMC4909362
http://europepmc.org/articles/PMC4909362
Autor:
Jessica Gasparello, Monica Borgatti, Roberto Gambari, Giulia Breveglieri, Enrica Fabbri, Nicoletta Bianchi, Alessia Finotti
Publikováno v:
Pharmacological Research
Graphical abstract
Rapamycin, an inhibitor of mTOR activity, is a potent inducer of erythroid differentiation and fetal hemoglobin production in β-thalassemic patients. Mithramycin (MTH) was studied to see if this inducer of K562 differentiatio
Rapamycin, an inhibitor of mTOR activity, is a potent inducer of erythroid differentiation and fetal hemoglobin production in β-thalassemic patients. Mithramycin (MTH) was studied to see if this inducer of K562 differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fcfc10bd4dd56e10a77d79271690d7
https://hdl.handle.net/11577/3478504
https://hdl.handle.net/11577/3478504
Autor:
Zakaria, Albatoul, Berthault, Claire, Cosson, Bertrand, Jung, Vincent, Guerrera, Ida Chiara, Rachdi, Latif, Scharfmann, Raphael
Publikováno v:
The Journal of Biological Chemistry
Glucose-mediated signaling regulates the expression of a limited number of genes in human pancreatic β-cells at the transcriptional level. However, it is unclear whether glucose plays a role in posttranscriptional RNA processing or translational con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::086e8c31a0aa12b12b5069857d6dcb91