Zobrazeno 1 - 10
of 168
pro vyhledávání: '"RANDY N. ROSIER"'
Autor:
Randy N. Rosier, Supriya G. Mohile, Gary R. Morrow, Luke J. Peppone, Karen M. Mustian, Jennifer K. Carroll, Jason Q. Purnell, Michelle C. Janelsins
Publikováno v:
Supportive Care in Cancer. 22:245-251
Breast cancer treatments (chemotherapy and hormone therapy) can cause a rapid loss in bone mineral density, leading to osteoporosis and fractures later in life. Fortunately, preventative measures (vitamin D, exercise, etc.) can delay bone loss if emp
Autor:
Erik R. Sampson, Randy N. Rosier, Meina Wang, Resika Ubayawardena, Jonathan D. Holz, Tzong-Jen Sheu, Michael J. Zuscik, J. Edward Puzas, Eric E. Beier
Publikováno v:
Journal of Orthopaedic Research. 30:1760-1766
Lead remains a significant environmental toxin, and we believe we may have identified a novel target of lead toxicity in articular chondrocytes. These cells are responsible for the maintenance of joint matrix, and do so under the regulation of TGF-β
Autor:
Brad A Martin, Edward M. Schwarz, Randy N. Rosier, Chao Xie, Regis J. O'Keefe, Erik R. Sampson, Aimee E Morris
Publikováno v:
Journal of Bone and Mineral Research. 26:1283-1294
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Ninety percent of patients who present with metastatic and 30% to 40% of patients with nonmetastatic disease experience relapse, creating an urgent need for novel th
Autor:
Mary E. Reid, Michelle C. Janelsins, Yousef Zakharia, Jason Q. Purnell, Randy N. Rosier, Gary R. Morrow, Karen M. Mustian, Donald L. Trump, Luke J. Peppone, Alissa Huston
Publikováno v:
Breast Cancer Research and Treatment. 127:171-177
Vitamin D deficiency in the patients treated for breast cancer is associated with numerous adverse effects (bone loss, arthralgia, and falls). The first aim of this study was to assess vitamin D status, determined by 25-OH vitamin D levels, among wom
Autor:
Hani A. Awad, Randy N. Rosier, Edward M. Schwarz, Michael J. Zuscik, Krista L. Canary, Matthew J. Hilton, Erik R. Sampson, Regis J. O'Keefe, Christopher A. Beck, Di Chen, John P. Ketz
Publikováno v:
Journal of Orthopaedic Research. 29:1145-1151
The goals of our study were to establish quantitative outcomes for assessing murine knee arthritis and develop an Arthritis Index that incorporates multiple outcomes into a single calculation that provides enhanced sensitivity. Using an accepted mode
Autor:
Randy N. Rosier, Justin A. Jacobson, Laura Yanoso-Scholl, Edward M. Schwarz, Gino Bradica, Tulin Dadali, Susan V. Bukata, Regis J. O'Keefe, David G. Reynolds, Edward J. Puzas, Michael J. Zuscik, Hani A. Awad
Publikováno v:
Tissue Engineering Part A. 17:389-398
To investigate the efficacy of endocrine parathyroid hormone treatment on tissue-engineered bone regeneration, massive femoral defects in C57Bl/6 mice were reconstructed with either 100:0 or 85:15 poly-lactic acid (PLA)/beta-tricalcium phosphate (β-
Publikováno v:
Journal of Orthopaedic Research. 29:623-632
Soft tissue sarcoma (STS) is a rare malignancy that is generally resistant to chemotherapy. We investigated the ability of the histone deacetylase inhibitor vorinostat to sensitize STS cells versus normal fibroblasts to chemotherapy. Fibrosarcoma, le
Autor:
Randy N. Rosier, Luke J. Peppone, Michelle C. Janelsins, Kenneth M. Piazza, Karen M. Mustian, Oxana Palesh, Tom V. Darling, Jason Q. Purnell, Gary R. Morrow
Publikováno v:
Clinical Breast Cancer. 10:224-229
Treatments for breast cancer, specifically hormonal therapy, accelerate bone loss (BL) among breast cancer survivors, leading to osteoporosis and an increase in fracture risk. Tai Chi Chuan (TCC) is a moderate form of weight-bearing exercise, equival
Publikováno v:
Annals of the New York Academy of Sciences. 1192:344-350
The early cellular events during the development of osteoarthritis (OA) are accelerated articular chondrocyte maturation and extracellular matrix degradation, which are usually seen in the weight-bearing region of articular cartilage. The results of
Autor:
Jason Q. Purnell, Mary E. Reid, Randy N. Rosier, S. Hebl, Karen M. Mustian, Marilyn N. Ling, Oxana Palesh, Luke J. Peppone, Alissa Huston, Gary R. Morrow
Publikováno v:
Osteoporosis International. 21:1133-1149
Osteoporosis, a skeletal disorder characterized by a reduction in bone strength, increases fracture risk. Primary osteoporosis is usually a result of reduced bone mineral density as a consequence of natural aging. Secondary osteoporosis is usually a