Zobrazeno 1 - 10
of 144
pro vyhledávání: '"RANDALL J. MRSNY"'
Autor:
Sage E. Foley, Christine Tuohy, Merran Dunford, Michael J. Grey, Heidi De Luca, Caitlin Cawley, Rose L. Szabady, Ana Maldonado-Contreras, Jean Marie Houghton, Doyle V. Ward, Randall J. Mrsny, Beth A. McCormick
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a c
Externí odkaz:
https://doaj.org/article/91d5522180234af2941f779d05d4a612
Autor:
Randall J. Mrsny, Tahir A. Mahmood
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1006 (2021)
Due to a lack of safe and effective oral delivery strategies for most protein and peptide therapeutics, pharmaceutical drug developers have focused on parenteral routes to administer these agents. Recent advances in delivery technologies have now sho
Externí odkaz:
https://doaj.org/article/0faa98abc9b64ef0bce3cb158e19249a
Autor:
Ruiying Li, Floriane Laurent, Alistair Taverner, Julia Mackay, Paul A. De Bank, Randall J. Mrsny
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1171 (2021)
The low permeability of nanoparticles (NPs) across the intestinal epithelium remains a major challenge for their application of delivering macromolecular therapeutic agents via the oral route. Previous studies have demonstrated the epithelial transcy
Externí odkaz:
https://doaj.org/article/602ca513ac704db8817e753a337b417b
Autor:
Bailu Xie, Jan Hänsel, Vanessa Mundorf, Janina Betz, Irene Reimche, Mert Erkan, Ibrahim Büdeyri, Anne Gesell, Russell G. Kerr, Ni Putu Ariantari, Haiqian Yu, Peter Proksch, Nicole Teusch, Randall J. Mrsny
Publikováno v:
Bioengineering, Vol 7, Iss 2, p 57 (2020)
Current therapies for treating pancreatic ductal adenocarcinoma (PDAC) are largely ineffective, with the desmoplastic environment established within these tumors being considered a central issue. We established a 3D spheroid co-culture in vitro model
Externí odkaz:
https://doaj.org/article/aee05bbd4668452992caa19650fc000f
Autor:
Andrew Zukauskas, Randall J. Mrsny, Paula Cortés Barrantes, Jerrold R. Turner, John M. Leong, Beth A. McCormick
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Streptococcus pneumoniae remains a source of morbidity and mortality in both developed and underdeveloped nations of the world. Disease can manifest as pneumonia, bacteremia, and meningitis, depending on the localization of infection. Intere
Externí odkaz:
https://doaj.org/article/4b7d319a3177468ebc2a90249196cf2b
Autor:
John Wahlich, Arpan Desai, Francesca Greco, Kathryn Hill, Arwyn T. Jones, Randall J. Mrsny, Gianfranco Pasut, Yvonne Perrie, F. Philipp Seib, Leonard W. Seymour, Ijeoma F. Uchegbu
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 210 (2019)
A special symposium of the Academy of Pharmaceutical Sciences Nanomedicines Focus Group reviewed the current status of the use of nanomedicines for the delivery of biologics drugs. This meeting was particularly timely with the recent approval of the
Externí odkaz:
https://doaj.org/article/7b044c8be3c845ceb5e4172cb9de0e79
Autor:
Randall J. Mrsny
Publikováno v:
The AAPS Journal. 24
Mankind has recently had to deal a series of virus-mediated pandemics, resulting in extensive morbidity and mortality rates that have severely strained healthcare systems. While dealing with viral infections as a healthcare concern is not new, our ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd47c4a28ab72db1d166647742e70745
https://doi.org/10.1208/s12248-022-00754-6
https://doi.org/10.1208/s12248-022-00754-6
Publikováno v:
International journal of pharmaceutics: X. 4
Parenteral administrations are a mainstay of clinical drug delivery. Intramuscular (IM) injections deposit drug directly into skeletal muscle bellies, providing rapid systemic uptake due to the highly vascularized nature of this site. The potential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d62d65958d2e91e08e9dcf95da99d5e
https://pubmed.ncbi.nlm.nih.gov/36065415
https://pubmed.ncbi.nlm.nih.gov/36065415
Autor:
Radhika C. Desai, Hyo Jin Kim, Julia D. Mackay, Weijun Feng, Randall J. Mrsny, Lisa Song, Linh P. Nyugen, Nicole C. Fay, Mahmood Tahir, Sally Postlethwaite, Apurva Chandalia, Baby Periyanayaki Muthusamy, Keyi Liu, Michael P. Coyle, Olson Charles, Elbert Seto, Tom Hunter, Khushdeep Mangat, Alistair Taverner, Minji Seung, Aatif Alam, Maziyar Saberi
Publikováno v:
J Immunol
IL-10 is a potent anti-inflammatory cytokine capable of suppressing a number of proinflammatory signals associated with intestinal inflammatory diseases, such as ulcerative colitis and Crohn's disease. Clinical use of human IL-10 (hIL-10) has been li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcacdc98e95024eef8eb40f1c5cc0b2a
https://doi.org/10.4049/jimmunol.2000848
https://doi.org/10.4049/jimmunol.2000848
Publikováno v:
Journal of Controlled Release. 321:475-482
Subcutaneous (SC) delivery of biotherapeutics is well established as a route of administration across many therapeutic areas and has been shown to be effective and well-tolerated. It can offer several advantages over intravenous administration. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79153038ef81532cdb3ae4ffdd6ef142
https://doi.org/10.1016/j.jconrel.2020.02.036
https://doi.org/10.1016/j.jconrel.2020.02.036