Zobrazeno 1 - 10
of 235
pro vyhledávání: '"RANDALL J. MRSNY"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100125- (2022)
Parenteral administrations are a mainstay of clinical drug delivery. Intramuscular (IM) injections deposit drug directly into skeletal muscle bellies, providing rapid systemic uptake due to the highly vascularized nature of this site. The potential t
Externí odkaz:
https://doaj.org/article/4af46d59bedb411f9a344e6d639c590c
Autor:
Sage E. Foley, Christine Tuohy, Merran Dunford, Michael J. Grey, Heidi De Luca, Caitlin Cawley, Rose L. Szabady, Ana Maldonado-Contreras, Jean Marie Houghton, Doyle V. Ward, Randall J. Mrsny, Beth A. McCormick
Publikováno v:
Microbiome, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen. Recent studies bring to light that P-gp also confers a c
Externí odkaz:
https://doaj.org/article/91d5522180234af2941f779d05d4a612
Autor:
Christopher S. Brazel
Publikováno v:
Journal of the American Chemical Society. 127:1590-1590
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6fa7eb7c4922ff99822894f0fa7b1d6
https://doi.org/10.1021/ja040974h
https://doi.org/10.1021/ja040974h
Autor:
Randall J. Mrsny, Tahir A. Mahmood
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1006 (2021)
Due to a lack of safe and effective oral delivery strategies for most protein and peptide therapeutics, pharmaceutical drug developers have focused on parenteral routes to administer these agents. Recent advances in delivery technologies have now sho
Externí odkaz:
https://doaj.org/article/0faa98abc9b64ef0bce3cb158e19249a
Autor:
Ruiying Li, Floriane Laurent, Alistair Taverner, Julia Mackay, Paul A. De Bank, Randall J. Mrsny
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1171 (2021)
The low permeability of nanoparticles (NPs) across the intestinal epithelium remains a major challenge for their application of delivering macromolecular therapeutic agents via the oral route. Previous studies have demonstrated the epithelial transcy
Externí odkaz:
https://doaj.org/article/602ca513ac704db8817e753a337b417b
Autor:
Bailu Xie, Jan Hänsel, Vanessa Mundorf, Janina Betz, Irene Reimche, Mert Erkan, Ibrahim Büdeyri, Anne Gesell, Russell G. Kerr, Ni Putu Ariantari, Haiqian Yu, Peter Proksch, Nicole Teusch, Randall J. Mrsny
Publikováno v:
Bioengineering, Vol 7, Iss 2, p 57 (2020)
Current therapies for treating pancreatic ductal adenocarcinoma (PDAC) are largely ineffective, with the desmoplastic environment established within these tumors being considered a central issue. We established a 3D spheroid co-culture in vitro model
Externí odkaz:
https://doaj.org/article/aee05bbd4668452992caa19650fc000f
Autor:
Andrew Zukauskas, Randall J. Mrsny, Paula Cortés Barrantes, Jerrold R. Turner, John M. Leong, Beth A. McCormick
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT Streptococcus pneumoniae remains a source of morbidity and mortality in both developed and underdeveloped nations of the world. Disease can manifest as pneumonia, bacteremia, and meningitis, depending on the localization of infection. Intere
Externí odkaz:
https://doaj.org/article/4b7d319a3177468ebc2a90249196cf2b
Autor:
Maria Daniela Garcia-Castillo, Daniel J-F Chinnapen, Yvonne M te Welscher, Rodrigo J Gonzalez, Samir Softic, Michele Pacheco, Randall J Mrsny, C Ronald Kahn, Ulrich H von Andrian, Jesper Lau, Bradley L Pentelute, Wayne I Lencer
Publikováno v:
eLife, Vol 7 (2018)
Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of i
Externí odkaz:
https://doaj.org/article/10a0616a7f8144d69071f2819bf380d6
Autor:
Randall J. Mrsny
Publikováno v:
The AAPS Journal. 24
Mankind has recently had to deal a series of virus-mediated pandemics, resulting in extensive morbidity and mortality rates that have severely strained healthcare systems. While dealing with viral infections as a healthcare concern is not new, our ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd47c4a28ab72db1d166647742e70745
https://doi.org/10.1208/s12248-022-00754-6
https://doi.org/10.1208/s12248-022-00754-6
Autor:
John Wahlich, Arpan Desai, Francesca Greco, Kathryn Hill, Arwyn T. Jones, Randall J. Mrsny, Gianfranco Pasut, Yvonne Perrie, F. Philipp Seib, Leonard W. Seymour, Ijeoma F. Uchegbu
Publikováno v:
Pharmaceutics, Vol 11, Iss 5, p 210 (2019)
A special symposium of the Academy of Pharmaceutical Sciences Nanomedicines Focus Group reviewed the current status of the use of nanomedicines for the delivery of biologics drugs. This meeting was particularly timely with the recent approval of the
Externí odkaz:
https://doaj.org/article/7b044c8be3c845ceb5e4172cb9de0e79