Zobrazeno 1 - 10
of 67
pro vyhledávání: '"RANDALL H. FRIEDLINE"'
Autor:
Randall H. Friedline, Hye Lim Noh, Sujin Suk, Mahaa Albusharif, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Bukyung Kim, Allison M. Kim, Lauren H. Kim, Lauren A. Tauer, Natalie M. Baez Torres, Stephanie Choi, Bo-Yeon Kim, Suryateja D. Rao, Kaushal Kasina, Cheng Sun, Benjamin J. Toles, Chan Zhou, Zixiu Li, Vivian M. Benoit, Payal R. Patel, Doris X. T. Zheng, Kunikazu Inashima, Annika Beaverson, Xiaodi Hu, Duy A. Tran, Werner Muller, Dale L. Greiner, Alan C. Mullen, Ki Won Lee, Jason K. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Obesity is a major cause of metabolic dysfunction-associated steatohepatitis (MASH) and is characterized by inflammation and insulin resistance. Interferon-γ (IFNγ) is a pro-inflammatory cytokine elevated in obesity and modulating macropha
Externí odkaz:
https://doaj.org/article/8e5cb5e93c2e43288feb95e635cd27f8
Autor:
Randall H. Friedline, Hye Lim Noh, Sujin Suk, Mahaa Albusharif, Sezin Dagdeviren, Suchaorn Saengnipanthkul, Bukyung Kim, Allison M. Kim, Lauren H. Kim, Lauren A. Tauer, Natalie M. Baez Torres, Stephanie Choi, Bo-Yeon Kim, Suryateja D. Rao, Kaushal Kasina, Cheng Sun, Benjamin J. Toles, Chan Zhou, Zixiu Li, Vivian M. Benoit, Payal R. Patel, Doris X. T. Zheng, Kunikazu Inashima, Annika Beaverson, Xiaodi Hu, Duy A. Tran, Werner Muller, Dale L. Greiner, Alan C. Mullen, Ki Won Lee, Jason K. Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/4fd7ed9712ca43fbbfea0936d917d2b4
Autor:
Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101780- (2023)
Objectives: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient a
Externí odkaz:
https://doaj.org/article/8509853fb6d444bb83dafa8e5ebf8337
Autor:
Qingbo Chen, Lei Huang, Dongning Pan, Kai Hu, Rui Li, Randall H. Friedline, Jason K. Kim, Lihua Julie Zhu, David A. Guertin, Yong-Xu Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The signaling mechanisms regulating adipose thermogenesis have not been fully elucidated. Here, the authors show that a brown fat-enriched adipokine ADISSP promotes adipose thermogenesis and improves metabolic health independently of b-adrenergic rec
Externí odkaz:
https://doaj.org/article/8345619aee974758834d427199e5cc83
Autor:
Ye Tian, Kritika Mehta, Matthew J. Jellinek, Hao Sun, Wei Lu, Ruicheng Shi, Kevin Ingram, Randall H. Friedline, Jason K. Kim, Jongsook Kim Kemper, David A. Ford, Kai Zhang, Bo Wang
Publikováno v:
Advanced Science, Vol 10, Iss 18, Pp n/a-n/a (2023)
Abstract The liver plays a central role in regulating glucose and lipid metabolism. Aberrant insulin action in the liver is a major driver of selective insulin resistance, in which insulin fails to suppress glucose production but continues to activat
Externí odkaz:
https://doaj.org/article/9b28f14487204e688c30990ee63d6620
Autor:
Emmanouela Tsagkaraki, Sarah M. Nicoloro, Tiffany DeSouza, Javier Solivan-Rivera, Anand Desai, Lawrence M. Lifshitz, Yuefei Shen, Mark Kelly, Adilson Guilherme, Felipe Henriques, Nadia Amrani, Raed Ibraheim, Tomas C. Rodriguez, Kevin Luk, Stacy Maitland, Randall H. Friedline, Lauren Tauer, Xiaodi Hu, Jason K. Kim, Scot A. Wolfe, Erik J. Sontheimer, Silvia Corvera, Michael P. Czech
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Worldwide pandemics of obesity and diabetes prompt an urgent need for new approaches to their prevention and cure. Here the authors present a CRISPR-based strategy that enhances the therapeutic potential of human adipocytes when implanted in obese mi
Externí odkaz:
https://doaj.org/article/9db95209ec9c4296b7f96552abbf9db0
Autor:
Kalpana D. Acharya, Randall H. Friedline, Doyle V. Ward, Madeline E. Graham, Lauren Tauer, Doris Zheng, Xiaodi Hu, Willem M. de Vos, Beth A. McCormick, Jason K. Kim, Marc J. Tetel
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Estrogens protect against weight gain and metabolic disruption in women and female rodents. Aberrations in the gut microbiota composition are linked to obesity and metabolic disorders. Furthermore, estrogen-mediated protection against diet-induced me
Externí odkaz:
https://doaj.org/article/165287e9809e4a129a026af32e7dca2d
Autor:
Suchaorn Saengnipanthkul, Hye Lim Noh, Randall H. Friedline, Sujin Suk, Stephanie Choi, Nicholas K. Acosta, Duy A. Tran, Xiaodi Hu, Kunikazu Inashima, Allison M. Kim, Ki Won Lee, Jason K. Kim
Publikováno v:
Physiological Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)
Abstract Increasing evidence shows a potential link between the perinatal nutrient environment and metabolic outcome in offspring. Here, we investigated the effects of maternal feeding of a high‐fat diet (HFD) during the perinatal period on hepatic
Externí odkaz:
https://doaj.org/article/7e3e901846094972a3f3f8a6e838bb42
Autor:
Martina Chrudinová, François Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiří Jiráček, C. Ronald Kahn, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101121- (2021)
Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to hu
Externí odkaz:
https://doaj.org/article/6021b0b3fea045b7b555497608ce50e0
Autor:
Anu Shah, Sezin Dagdeviren, Jordan P. Lewandowski, Angela B. Schmider, Elisabeth M. Ricci-Blair, Niranjana Natarajan, Henna Hundal, Hye Lim Noh, Randall H. Friedline, Charles Vidoudez, Jason K. Kim, Amy J. Wagers, Roy J. Soberman, Richard T. Lee
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101521- (2020)
Summary: Increased consumption of fats and added sugars has been associated with an increase in metabolic syndromes. Here we show that mice chronically fed an energy-rich diet (ERD) with high fat and moderate sucrose have enhanced the absorption of a
Externí odkaz:
https://doaj.org/article/24e910ae67174beba18cf61e73cb6974