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MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans

Autor: Koch, Alexander W. ^*, Schiering, Nikolaus, Melkko, Samu, Ewert, Stefan, Salter, Janeen, Zhang, Yiming, McCormack, Peter, Yu, Jianying, Huang, Xueming, Chiu, Yu-Hsin, Chen, Zhiping, Schleeger, Simone, Horny, Geraldine, DiPetrillo, Keith, Muller, Lionel, Hein, Andreas, Villard, Frederic, Scharenberg, Meike, Ramage, Paul, Hassiepen, Ulrich, Côté, Serge, DeGagne, Julie, Krantz, Carsten, Eder, Jörg, Stoll, Brian, Kulmatycki, Kenneth, Feldman, David L., Hoffmann, Peter, Basson, Craig T., Frost, Robert J.A., Khder, Yasser ^*

Publikováno v: In Blood 28 March 2019 133(13):1507-1516

Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19

Autor: Várnai, Csilla, Palles, Claire, Arnold, Roland, Curley, Helen M., Purshouse, Karin, Cheng, Vinton W. T., Booth, Stephen, Campton, Naomi A., Collins, Graham P., Hughes, Daniel J., Kulasekararaj, Austin G., Lee, Alvin J. X., Olsson-brown, Anna C., Sharma-oates, Archana, Van Hemelrijck, Mieke, Lee, Lennard Y. W., Kerr, Rachel, Middleton, Gary, Cazier, Jean-baptiste, Pugh, Sian, Corrie, Pippa, Bedair, Ahmed, Hewish, Madeleine, Leonard, Pauline, Illingworth, Jack, Hibbs, Stephen, Diamantis, Nicolaos, Massalha, Samah, Fuller, Claire, Usbourne, Caroline, Gilbert, Duncan, Davies, Jennifer, Newsom-davis, Tom, Sharkey, Rachel, Lee, Rebecca, Tivey, Ann, Shotton, Rohan, Griffin, Clare, Horsley, Laura, Shamas, Simon, Sacco, Joseph J, Choudhury, Madbuba, Noble, Jillian, Shaw, Heather, Bolton, Rachel, Ferreira, Ana, Hall, Peter, Ramage, Paul, Bhosle, Jaishree, Massey, Alison, Hill, Michaela, Mukherjee, Leena, Ghaus, Aisha, Derby, Sarah, Brown, Sean, Lowndes, Sarah, Dolly, Saorise, Russell, Beth, Moss, Charlotte, Muller, Daniel, Pillai, Annet, Lowe, Shakeel, Cook, Lucy, Scrase, Christopher, Jyothirmayi, Rema, Board, Ruth, Cornthwaite, Stephanie, Parikh, Shefail, Cattell, Emma, Cox, Nicola, Gault, Abigail, Moody, Sam, Dobeson, Caroline, Baxter, Mark, Roques, Tom, Pawsey, Alexander, Oakes, Roderick, Melcher, Lucinda, Chan, Olivia, Ayers, Sarah, Bowyer, Helen, Althohami, Mohammed, Mittal, Sajjan, Feeney, Laura, Aujayeb, Avinash, Sheikh, Omar, Kathirgamakarthigeyan, Sangary, Woodcock, Victoria, Holt, Francesca, Wyatt, Simon, Topping, Oliver, Tilby, Michael, Bhattacharyya, Madhumita, Burke, Emma, Ellis, Shawn, Chacko, Joseph, Rabbi, Taslima, Rowe, Michael, Sargent, Rebecca, Thirlwell, Christina, Gibson, Jack, Goldstein, Robert, Fittall, Mathew, Gennatas, Spyridon, Okines, Alicia, Best, James, Tillett, Tania, Renninson, Emily, Grumett, Simon, Barrington, Craig, Pettengell, Ruth, Peng, Yingyying, Chackathayil, Julia, Akingboye, Akinfemi, Hollis, Helen, Shin Chin, Ik, Bisht, Vartika, Hartley, Simon, Middleton, Christopher P, Goel, Anshita, Protheroe, Emily, Naksukpaiboon, Paingfan, Anil, Iris, Michell, Joel, D'costa, Jamie, Wu, Anjui, Ottaviani, Diego, Soosaipillai, Gehan, Galazi, Myria, Chopra, Neha, Benafif, Sarah, Sng, Christopher Ct, Wong, Sophia Yn, Scott-brown, Martin, Copson, Ellen, Robinson, Timothy, Hudson, Zoe, Smith, Fiona, Abdulnabi Mohamed, Ali-abdulnabi, Angelakas, Angelos, Eastlake, Leoni, Poon-king, Ashley, Brunner, Clair, Kwan, Amy, Maynard, Alec, Boyce, Hayley, Spurrell, Emma, Peck, Rahul, Kurec, Bartlomiej

Publikováno v: Várnai, C, Palles, C, Arnold, R, Curley, H M, Purshouse, K, Cheng, V W T, Booth, S, Campton, N A, Collins, G P, Hughes, D J, Kulasekararaj, A G, Lee, A J X, Olsson-brown, A C, Sharma-oates, A, Van Hemelrijck, M, Lee, L Y W, Kerr, R, Middleton, G, Cazier, J, Pugh, S, Corrie, P, Bedair, A, Hewish, M, Leonard, P, Illingworth, J, Hibbs, S, Diamantis, N, Massalha, S, Fuller, C, Usbourne, C, Gilbert, D, Davies, J, Newsom-davis, T, Sharkey, R, Lee, R, Tivey, A, Shotton, R, Griffin, C, Horsley, L, Shamas, S, Sacco, J J, Choudhury, M, Noble, J, Shaw, H, Bolton, R, Ferreira, A, Hall, P, Ramage, P, Bhosle, J, Massey, A, Hill, M, Mukherjee, L, Ghaus, A, Derby, S, Brown, S, Lowndes, S, Dolly, S, Russell, B, Moss, C, Muller, D, Pillai, A, Lowe, S, Cook, L, Scrase, C, Jyothirmayi, R, Board, R, Cornthwaite, S, Parikh, S, Cattell, E, Cox, N, Gault, A, Moody, S, Dobeson, C, Baxter, M, Roques, T, Pawsey, A, Oakes, R, Melcher, L, Chan, O, Ayers, S, Bowyer, H, Althohami, M, Mittal, S, Feeney, L, Aujayeb, A, Sheikh, O, Kathirgamakarthigeyan, S, Woodcock, V, Holt, F, Wyatt, S, Topping, O, Tilby, M, Bhattacharyya, M, Burke, E, Ellis, S, Chacko, J, Rabbi, T, Rowe, M, Sargent, R, Thirlwell, C, Gibson, J, Goldstein, R, Fittall, M, Gennatas, S, Okines, A, Best, J, Tillett, T, Renninson, E, Grumett, S, Barrington, C, Pettengell, R, Peng, Y, Chackathayil, J, Akingboye, A, Hollis, H, Shin Chin, I, Bisht, V, Hartley, S, Middleton, C P, Goel, A, Protheroe, E, Naksukpaiboon, P, Anil, I, Michell, J, D'costa, J, Wu, A, Ottaviani, D, Soosaipillai, G, Galazi, M, Chopra, N, Benafif, S, Sng, C C, Wong, S Y, Scott-brown, M, Copson, E, Robinson, T, Hudson, Z, Smith, F, Abdulnabi Mohamed, A, Angelakas, A, Eastlake, L, Poon-king, A, Brunner, C, Kwan, A, Maynard, A, Boyce, H, Spurrell, E, Peck, R & Kurec, B 2022, ' Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19 ', JAMA Network Open, vol. 5, no. 2, pp. e220130 . https://doi.org/10.1001/jamanetworkopen.2022.0130
YW Lee DPhil, L, Kerr, R, Middleton, G & Cazier, J-B & Hall, P S 2022, ' Mortality among Adults with Cancer undergoing Chemotherapy or Immunotherapy Infected with COVID-19 ', JAMA Network Open . https://doi.org/10.1001/jamanetworkopen.2022.0130

Importance Large cohorts of patients with active cancers and COVID-19 infection are needed to provide evidence of the association of recent cancer treatment and cancer type with COVID-19 mortality.Objective To evaluate whether systemic anticancer tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf6eab1ac50eb856169d191fb9931e
https://pubmed.ncbi.nlm.nih.gov/35394519

Chaperone over-expression in Escherichia coli: Apparent increased yields of soluble recombinant protein kinases are due mainly to soluble aggregates

Autor: Haacke, Annette, Fendrich, Gabriele, Ramage, Paul, Geiser, Martin

Publikováno v: In Protein Expression and Purification 2009 64(2):185-193

COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

Autor: Lee, Lennard Y. W., Cazier, Jean-Baptiste, Starkey, Thomas, Briggs, Sarah E. W., Arnold, Roland, Bisht, Vartika, Booth, Stephen, Campton, Naomi A., Cheng, Vinton W. T., Collins, Graham, Curley, Helen M., Earwaker, Philip, Fittall, Matthew W., Gennatas, Spyridon, Goel, Anshita, Hartley, Simon, Hughes, Daniel J., Kerr, David, Lee, Alvin J. X., Lee, Rebecca J., Lee, Siow Ming, Mckenzie, Hayley, Middleton, Chris P., Murugaesu, Nirupa, Newsom-Davis, Tom, Olsson-Brown, Anna C., Palles, Claire, Powles, Thomas, Protheroe, Emily A., Purshouse, Karin, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley J., Topping, Oliver, Turnbull, Chris D., Várnai, Csilla, Briggs, Adam D. M., Middleton, Gary, Kerr, Rachel, Gault, Abigail, Agnieszka, Michael, Bedair, Ahmed, Ghaus, Aisha, Akingboye, Akinfemi, Maynard, Alec, Pawsey, Alexander, Mohamed, Ali Abdulnabi, Okines, Alicia, Massey, Alison, Kwan, Amy, Ferreira, Ana, Angelakas, Angelos, Wu, Anjui, Tivey, Ann, Armstrong, Anne, Madhan, Annet, Pillai, Annet, Poon-King, Ashley, Kurec, Bartlomiej, Usborne, Caroline, Dobeson, Caroline, Thirlwell, Christina, Mitchell, Christian, Sng, Christopher, Scrase, Christopher, Jingree, Christopher, Brunner, Clair, Fuller, Claire, Griffin, Clare, Barrington, Craig, Muller, Daniel, Ottaviani, Diego, Gilbert, Duncan, Tacconi, Eliana, Copson, Ellen, Renninson, Emily, Cattell, Emma, Burke, Emma, Smith, Fiona, Holt, Francesca, Soosaipillai, Gehan, Boyce, Hayley, Shaw, Heather, Hollis, Helen, Bowyer, Helen, Anil, Iris, Illingworth, Jack, Gibson, Jack, Bhosle, Jaishree, Best, James, Barrett, Jane, Noble, Jillian, Sacco, Joseph, Chacko, Joseph, Chackathayil, Julia, Banfill, Kathryn, Feeney, Laura, Horsley, Laura, Cammaert, Lauren, Mukherjee, Leena, Eastlake, Leonie, Devereaux, Louise, Melcher, Lucinda, Cook, Lucy, Teng, Mabel, Hewish, Madeleine, Bhattacharyya, Madhumita, Choudhury, Mahbuba, Baxter, Mark, Scott-Brown, Martin, Fittall, Matthew, Tilby, Michael, Rowe, Michael, Alihilali, Mohammed, Galazi, Myria, Yousaf, Nadia, Chopra, Neha, Cox, Nicola, Chan, Olivia, Sheikh, Omar, Ramage, Paul, Greaves, Paul, Leonard, Pauline, Hall, Peter S., Naksukpaiboon, Piangfan, Corrie, Pippa, Peck, Rahul, Sharkey, Rachel, Bolton, Rachel, Sargent, Rebecca, Jyothirmayi, Rema, Goldstein, Robert, Oakes, Roderick, Shotton, Rohan, Kanani, Ruhi, Board, Ruth, Pettengell, Ruth, Claydon, Ryan, Moody, Sam, Massalha, Samah, Kathirgamakarthigeyan, Sangary, Dolly, Saoirse, Derby, Sarah, Lowndes, Sarah, Benafif, Sarah, Eeckelaers, Sarah, Kingdon, Sarah, Ayers, Sarah, Brown, Sean, Ellis, Shawn, Parikh, Shefali, Pugh, Sian, Shamas, Simon, Wyatt, Simon, Grumett, Simon, Lau, Sin, Wong, Yien Ning Sophia, McGrath, Sophie, Cornthwaite, Stephanie, Hibbs, Stephen, Tillet, Tania, Rabbi, Taslima, Robinson, Tim, Roques, Tom, Angelis, Vasileios, Woodcock, Victoria, Brown, Victoria, Peng, YingYing, Drew, Yvette, Hudson, Zoe, HASH(0x5651ca095ff8)

Publikováno v: DM Briggs, A, Middleton, P G & Kerr, R & Hall, P S 2020, ' COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study ', The Lancet Oncology . https://doi.org/10.1016/S1470-2045(20)30442-3
Lee, R 2020, ' COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study ', Lancet Oncology . https://doi.org/10.1016/S1470-2045(20)30442-3
The Lancet Oncology
The Lancet. Oncology

BACKGROUND: Patients with cancer are purported to have poor COVID-19 outcomes. However, cancer is a heterogeneous group of diseases, encompassing a spectrum of tumour subtypes. The aim of this study was to investigate COVID-19 risk according to tumou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10858d248a45a2ef5a69dd4a5c7b36da
https://www.pure.ed.ac.uk/ws/files/160193534/THELANCETONCOLOGY_D_20_01203_R3_2_002_K_P.pdf