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Akademický článek

Grape seed extract proanthocyanidins downregulate HIV- 1 entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheral blood mononuclear cells

Autor: MADHAVAN P NAIR, CHITHAN KANDASWAMI, SUPRIYA MAHAJAN, HARIKRISHNA N NAIR, RAM CHAWDA, THOMAS SHANAHAN, STANLEY A SCHWARTZ

Publikováno v: Biological Research, Vol 35, Iss 3-4, Pp 421-431 (2002)

Flavonoids and related polyphenols, in addition to their cardioprotective, anti-tumor, anti-inflammatory, anti-carcinogenic and anti-allergic activities, also possess promising anti-HIV effects. Recent studies documented that the ß-chemokine recepto

Externí odkaz: https://doaj.org/article/3dad65542ddc48cf940a90272f726951

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Identification of Physiologically Relevant Substrates for Cloned Gal: 3-O-Sulfotransferases (Gal3STs)

Autor: Sukhwinder S. Lakhaman, Sriram Neelamegham, Ram Chawda, Khushi L. Matta, Conrad F. Piskorz, E. V. Chandrasekaran

Publikováno v: Journal of Biological Chemistry. 279:10032-10041

Sulfated glycoconjugates regulate biological processes such as cell adhesion and cancer metastasis. We examined the acceptor specificities and kinetic properties of three cloned Gal:3-O-sulfotransferases (Gal3STs) ST-2, ST-3, and ST-4 along with a pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e179a7b46ca1a646e3d32db6e7eef0e4
https://doi.org/10.1074/jbc.m311989200

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The flavonoid, quercetin, differentially regulates Th-1 (IFNγ) and Th-2 (IL4) cytokine gene expression by normal peripheral blood mononuclear cells

Autor: Madhavan Nair, Ram Chawda, Chithan C. Kandaswami, Stanley A. Schwartz, Hari Krishnan Nair, Niranjan Kumar, Supriya D. Mahajan, Kailash C. Chadha, Raji E Nair

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1593:29-36

Flavonoids are plant metabolites that are dietary antioxidants and exert significant anti-tumor, anti-allergic, anti-inflammatory and anti-viral effects. It is generally accepted that Th-1 derived cytokines such as IL-2, IFNgamma and IL-12 promote ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854552a4e7a861075fcef2ba10d428b2
https://doi.org/10.1016/s0167-4889(02)00328-2

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Human ovarian cancer, lymphoma spleen, and bovine milk GlcNAc:β1,4Gal/GalNAc transferases: two molecular species in ovarian tumor and induction of GalNAcβ1,4Glc synthesis by α-lactalbumin

Autor: Ghamande Sharad, Conrad F. Piskorz, Khushi L. Matta, Alyssa Ta, Shashikant Lele, E. V. Chandrasekaran, Robert D. Locke, Ram Chawda, Kunle Odunsi

Publikováno v: Carbohydrate Research. 334:105-118

Affinity Gel-UDP was utilized to purify GlcNAc:beta1,4Gal/GalNAc transferases (Ts) from human lymphoma spleen, ovarian tumor, and ovarian cancer sera. Mn(2+) was found to be an absolute requirement for activity. Two molecular species containing both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6ff81043f1538fcf5c07eb6e258e90
https://doi.org/10.1016/s0008-6215(01)00150-1

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[Untitled]

Autor: Rakesh K. Jain, Khushi L. Matta, Ram Chawda, E. V. Chandrasekaran, John Rhodes, Conrad F. Piskorz

Publikováno v: Glycoconjugate Journal. 16:523-536

We found earlier in human breast and colon tumors, an augmented level of Gal : 3-O-sulfotransferase activities showing, respectively, an acceptor preference to blood group T-hapten (Group A enzymes) or Galbeta1,4GlcNAc (Group B enzymes) on the mucin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6caa87d5b01cb6ce7c11a22d234673fc
https://doi.org/10.1023/a:1007074005371

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Identification of physiologically relevant substrates for cloned Gal: 3-O-sulfotransferases (Gal3STs): distinct high affinity of Gal3ST-2 and LS180 sulfotransferase for the globo H backbone, Gal3ST-3 for N-glycan multiterminal Galbeta1, 4GlcNAcbeta units and 6-sulfoGalbeta1, 4GlcNAcbeta, and Gal3ST-4 for the mucin core-2 trisaccharide

Autor: E V, Chandrasekaran, Sukhwinder S, Lakhaman, Ram, Chawda, Conrad F, Piskorz, Sriram, Neelamegham, Khushi L, Matta

Publikováno v: The Journal of biological chemistry. 279(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f45f1180cd38cb3e64348cc2699235f4
https://pubmed.ncbi.nlm.nih.gov/14701868

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The binding characteristics and utilization of Aleuria aurantia, Lens culinaris and few other lectins in the elucidation of fucosyltransferase activities resembling cloned FT VI and apparently unique to colon cancer cells

Autor: E. V. Chandrasekaran, Ram Chawda, Robert D. Locke, John Rhodes, Conrad F. Piskorz, Khushi L. Matta

Publikováno v: Carbohydrate research. 338(9)

Human colon carcinoma cell fucosyltransferase (FT) in contrast to the FTs of several human cancer cell lines, utilized GlcNAcbeta1,4GlcNAcbeta-O-Bn as an acceptor, the product being resistant to alpha1,6-L-Fucosidase and its formation being completel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff14bad77d4f236be353b0c63529caa
https://pubmed.ncbi.nlm.nih.gov/12681913

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Biosynthesis of the carbohydrate antigenic determinants, Globo H, blood group H, and Lewis b: a role for prostate cancer cell alpha1,2-L-fucosyltransferase

Autor: Conrad F. Piskorz, Ram Chawda, E. V. Chandrasekaran, Khushi L. Matta, Robert D. Locke

Publikováno v: Glycobiology. 12(3)

Prostate carcinoma LNCaP cells were unique among several human cancer cell lines which include two other prostate cancer cell lines, PC-3 and DU-145, in expressing alpha1,2-L-fucosyltransferase (FT) as an exclusive FT activity. Affinity gel-GDP and S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c77bbc4ee1305958eb2681de33bb65d
https://pubmed.ncbi.nlm.nih.gov/11971859

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Human lung adenocarcinoma alpha1,3/4-L-fucosyltransferase displays two molecular forms, high substrate affinity for clustered sialyl LacNAc type 1 units as well as mucin core 2 sialyl LacNAc type 2 unit and novel alpha1,2-L-fucosylating activity

Autor: Jie Xia, Conrad F. Piskorz, Ram Chawda, E. V. Chandrasekaran, John Rhodes, Khushi L. Matta

Publikováno v: Glycobiology. 11(5)

Human lung tumor alpha1,3/4-L-fucosyltransferase (FT) was purified (2000-fold, 29% recovery) from 290 g of tissue by including a chromatography step on Affinity Gel-GDP. Two molecular forms (FTA, larger size carrying 15% alpha1,4-FT activity; FTB, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6eaa6ef3a81f0bbcab420ad243bae5
https://pubmed.ncbi.nlm.nih.gov/11425796

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