Zobrazeno 1 - 10
of 171
pro vyhledávání: '"RALPH L., KODELL"'
Publikováno v:
Journal of Statistical Software, Vol 16, Iss 1, Pp 1-14 (2006)
A computational tool for testing for a dose-related trend and/or a pairwise difference in the incidence of an occult tumor via an age-adjusted bootstrap-based poly-k test and the original poly-k test is presented in this paper. The poly-k test (Baile
Externí odkaz:
https://doaj.org/article/02442d76bdf645639e0073ab9299ecb1
Autor:
Ralph L. Kodell, Angelo Turturro
Publikováno v:
Dose-Response, Vol 2 (2004)
A two-stage, clonal-expansion model of liver tumor risk in mice was developed by Kodell et al. (Food Addit Contam 18:237–253, 2001) based on the hypothesis that fumonisin B 1 , a naturally occurring mycotoxin in corn, is not genotoxic, but rather c
Externí odkaz:
https://doaj.org/article/5f350c78dc6549448005356da0049682
Autor:
Chuanlei Zhang, Ralph L. Kodell
Publikováno v:
Artificial Intelligence in Medicine. 58:155-163
Objective: Although classification algorithms are promising tools to support clinical diagnosis and treatment of disease, the usual implicit assumption underlying these algorithms, that all patients are homogeneous with respect to characteristics of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be0b41f03e34befe955de9827c8e1cc1
https://doi.org/10.1016/j.artmed.2013.04.008
https://doi.org/10.1016/j.artmed.2013.04.008
Publikováno v:
Risk Analysis. 33:220-231
Food-borne infection is caused by intake of foods or beverages contaminated with microbial pathogens. Dose-response modeling is used to estimate exposure levels of pathogens associated with specific risks of infection or illness. When a single dose-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80f529ba4d05bea303c49dabe639d5f2
https://doi.org/10.1111/j.1539-6924.2012.01853.x
https://doi.org/10.1111/j.1539-6924.2012.01853.x
Publikováno v:
Radiation Research. 177:546-554
We present an introduction to, and examples of, Cox proportional hazards regression in the context of animal lethality studies of potential radioprotective agents. This established method is seldom used to analyze survival data collected in such stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ebdb6fdc2dae789dc8c33df79da8a7
https://doi.org/10.1667/rr2872.1
https://doi.org/10.1667/rr2872.1
Autor:
Ralph L. Kodell
Publikováno v:
Statistics in Biopharmaceutical Research. 4:118-124
The IARC guidance document on testing for tumorigenicity in long-term animal experiments (Peto et al. 1980) recommended a statistical test for dose-related trend that stratifies animals dying with tumors of a specific type according to whether the tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c76da4b3cb399e366fa4b2f421bfbc91
https://doi.org/10.1198/sbr.2010.10030
https://doi.org/10.1198/sbr.2010.10030
Autor:
Ralph L. Kodell, James J. Chen
Publikováno v:
Personalized Medicine. 7:171-178
Idiosyncratic liver toxicity that may lead to post-marketing removal of approved drugs can potentially be explained by the existence of hidden, sensitive subpopulations that are not large enough to affect premarketing toxicity assessments. We conside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483979cbaa67ab48742775103c19412f
https://doi.org/10.2217/pme.10.7
https://doi.org/10.2217/pme.10.7
Autor:
Ralph L. Kodell
Publikováno v:
Environmental and Ecological Statistics. 16:3-12
Although benchmark-dose methodology has existed for more than 20 years, benchmark doses (BMDs) still have not fully supplanted the no-observed-adverse-effect level (NOAEL) and lowest-observed-adverse-effect level (LOAEL) as points of departure from t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4dd250affbed722fed7caba03362ec
https://doi.org/10.1007/s10651-007-0075-3
https://doi.org/10.1007/s10651-007-0075-3
Autor:
Annette M. Shipp, Martha M. Moore, Robert H. Heflich, Ralph L. Kodell, Bruce C. Allen, Lynne T. Haber
Publikováno v:
Regulatory Toxicology and Pharmacology. 51:151-161
Under the new U.S. Environmental Protection Agency (EPA) Cancer Risk Assessment Guidelines [U.S. EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B, March 2005], the quantitative model chosen for cancer risk assessment is based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a31502c0b7b73ecb1768c57b3e98940
https://doi.org/10.1016/j.yrtph.2008.01.015
https://doi.org/10.1016/j.yrtph.2008.01.015
Publikováno v:
Computational Statistics & Data Analysis. 51:6166-6179
A robust classification procedure is developed based on ensembles of classifiers, with each classifier constructed from a different set of predictors determined by a random partition of the entire set of predictors. The proposed methods combine the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4abcc7ed4eca755e5b5953bb7f7ea78
https://doi.org/10.1016/j.csda.2006.12.043
https://doi.org/10.1016/j.csda.2006.12.043