Zobrazeno 1 - 10
of 1 517
pro vyhledávání: '"RAKESH K JAIN"'
Autor:
Keene L Abbott, Ahmed Ali, Bradley I Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D Landis, Rachel A Hongo, Kirsten L Young, Tenzin Kunchok, Christopher S Nabel, Kayla D Crowder, Johnathan R Kent, Maria Lucia L Madariaga, Rakesh K Jain, Kathryn E Beckermann, Caroline A Lewis, Clary B Clish, Alexander Muir, W Kimryn Rathmell, Jeffrey Rathmell, Matthew G Vander Heiden
Publikováno v:
eLife, Vol 13 (2024)
The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it is established that the local abundance of specific nutrients defines the metabolic paramete
Externí odkaz:
https://doaj.org/article/3b4cd2338c48457fa0f024644fdf44e6
Autor:
Meenal Datta, McCarthy Kennedy, Saeed Siri, Laura E Via, James W Baish, Lei Xu, Véronique Dartois, Clifton E Barry, Rakesh K Jain
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011847 (2024)
Physiological abnormalities in pulmonary granulomas-pathological hallmarks of tuberculosis (TB)-compromise the transport of oxygen, nutrients, and drugs. In prior studies, we demonstrated mathematically and experimentally that hypoxia and necrosis em
Externí odkaz:
https://doaj.org/article/b54bc0f89440443ca165ac06b7b9b370
Autor:
Chrysovalantis Voutouri, C Corey Hardin, Vivek Naranbhai, Mohammad R Nikmaneshi, Melin J Khandekar, Justin F Gainor, Lance L Munn, Rakesh K Jain, Triantafyllos Stylianopoulos
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0301780 (2024)
Critical illness, such as severe COVID-19, is heterogenous in presentation and treatment response. However, it remains possible that clinical course may be influenced by dynamic and/or random events such that similar patients subject to similar injur
Externí odkaz:
https://doaj.org/article/14299f1c215547adae64ad9a199da9f3
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 12, p e1011740 (2023)
Intratumoral injection of immunotherapy aims to maximize its activity within the tumor. However, cytokines are cleared via tumor vessels and escape from the tumor periphery into the host-tissue, reducing efficacy and causing toxicity. Thus, understan
Externí odkaz:
https://doaj.org/article/f783ee49e3834549b243a0f674b40de1
Autor:
Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/d26b0562d76f46329dc0083b74f9338e
Autor:
Stefani Spranger, Rakesh K Jain, Kim Nguyen, Arjun Bhutkar, Ivy Chen, Dig Bijay Mahat, Heena Kumra, Emily Metcalf, Sarah Castro, William W Ho, Brandon Sullivan, Leon K Yim, Vikash Chauhan, Hernandez Moura Silva, Phillip A Sharp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/794447e319c14e92a0c1865d72dd16fb
Autor:
Dai Fukumura, Rakesh K Jain, Peigen Huang, Lance L Munn, Patrik Andersson, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette, Neal I Lindeman, Shanmugarajan Krishnan, Sonu Subudhi, Ashwin Srinivasan Kumar, Jessica Posada, Pinji Lei
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/3a4c2f3027794cf79400ff96ec785d88
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 6, p e1011131 (2023)
Implementation of effective cancer treatment strategies requires consideration of how the spatiotemporal heterogeneities within the tumor microenvironment (TME) influence tumor progression and treatment response. Here, we developed a multi-scale thre
Externí odkaz:
https://doaj.org/article/d70a9382809347b8a9574405ea80126d
Autor:
Dai Fukumura, Rakesh K Jain, Jun Ren, Xinyue Dong, Zohreh Amoozgar, Somin Lee, Meenal Datta, Sylvie Roberge, Mark Duquette
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of multiple types of hematological malignancies, but have shown limited efficacy in patients with glioblastoma (GBM) or other solid tumors. This may be largely due to the immun
Externí odkaz:
https://doaj.org/article/596a942a981e432ca363975cf37ae1e0
Autor:
Alexander Quaas, Lipika Goyal, Andrew X Zhu, Mark Cobbold, Dan G Duda, Rakesh K Jain, Kohei Shigeta, Aya Matsui, Hiroto Kikuchi, Sebastian Klein, Emilie Mamessier, Ivy X Chen, Shuichi Aoki, Shuji Kitahara, Koetsu Inoue, Ayako Shigeta, Tai Hato, Rakesh R Ramjiawan, Daniel Staiculescu, Dieter Zopf, Lukas Fiebig, Gabriela S Hobbs, Simona Dima, Irinel Popescu, Peigen Huang, Lance L Munn
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background and purpose Combining inhibitors of vascular endothelial growth factor and the programmed cell death protein 1 (PD1) pathway has shown efficacy in multiple cancers, but the disease-specific and agent-specific mechanisms of benefit remain u
Externí odkaz:
https://doaj.org/article/3a16c10d09a0429d990a0dd5f6981ee3