Zobrazeno 1 - 10
of 1 113
pro vyhledávání: '"RAG2"'
Autor:
Jing Wang, Feiyan Zhu, Deling Jiao, Chang Yang, Junqi Wang, Fengchong Wang, Heng Zhao, Hong-Jiang Wei, Hong-Ye Zhao
Publikováno v:
Animals, Vol 14, Iss 17, p 2597 (2024)
Recombination-activating genes (RAGs) play a crucial role in the V(D)J recombination process and the development of immune cells. The development of the immune system and its mechanisms in pigs exhibit greater similarity to those of humans compared t
Externí odkaz:
https://doaj.org/article/7d3d853b4e284a6b89208af61b07f513
Autor:
Yu Jeong Roh, Jeong Eun Gong, Ji Eun Kim, You Jeong Jin, Hee Jin Song, Ayun Seol, Jumin Park, Yong Lim, Dae Youn Hwang
Publikováno v:
Laboratory Animal Research, Vol 39, Iss 1, Pp 1-14 (2023)
Abstract Background Recombination activating gene2 (Rag2) knockout (KO) mice are used widely in various research fields, including vaccine development, transplantation studies, and hematopoiesis research, but few studies have compared their phenotype
Externí odkaz:
https://doaj.org/article/bcc1bd2ec69c4d1fab2d76b5c8285d21
Akademický článek
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Akademický článek
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Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Clustered regularly interspaced short palindromic repeats (CRISPR) genome editing platform heralds a new era of gene therapy. Innovative treatments for life-threatening monogenic diseases of the blood and immune system are transitioning from semi-ran
Externí odkaz:
https://doaj.org/article/cf25462a05a24f5894038d6256bb07f3
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The closely linked recombination activating genes (RAG1 and RAG2) in vertebrates encode the core of the RAG recombinase that mediates the V(D)J recombination of the immunoglobulin and T-cell receptor genes. RAG1 and RAG2 homologues (RAG1L and RAG2L)
Externí odkaz:
https://doaj.org/article/ca84df3b2f784548bb3e9000ca0648da
Autor:
Renan B. Sper, Jessica Proctor, Odessa Lascina, Ling Guo, Kathryn Polkoff, Tobias Kaeser, Sean Simpson, Luke Borst, Katherine Gleason, Xia Zhang, Bruce Collins, Yanet Murphy, Jeffrey L. Platt, Jorge A. Piedrahita
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Mice with severe combined immunodeficiency are commonly used as hosts of human cells. Size, longevity, and physiology, however, limit the extent to which immunodeficient mice can model human systems. To address these limitations, we generated RAG2−
Externí odkaz:
https://doaj.org/article/7a3922f25e6c4f00a302e70e74c3ba8c
Autor:
Nicolas Pionnier, Julio Furlong-Silva, Stefano A. P. Colombo, Amy E. Marriott, Valerine C. Chunda, Bertrand L. Ndzeshang, Hanna Sjoberg, John Archer, Andrew Steven, Samuel Wanji, Mark J. Taylor, Joseph D. Turner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lymphatic filariasis and onchocerciasis are major neglected tropical diseases affecting over 90 million people worldwide with painful and profoundly disfiguring pathologies (such as lymphoedema or blindness). Type 2 inflammation is a hallmark of fila
Externí odkaz:
https://doaj.org/article/9dab80b843d444419be4b8c659f43b68
Autor:
Heng Zhao, Weijian Ye, Jianxiong Guo, Jiaoxiang Wang, Deling Jiao, Kaixiang Xu, Chang Yang, Shuhan Chen, Muhammad Ameen Jamal, Zhongbin Bai, Taiyun Wei, Jie Cai, Tien Dat Nguyen, Yubo Qing, Wenmin Cheng, Baoyu Jia, Honghui Li, Hong-Ye Zhao, Qingfeng Chen, Hong-Jiang Wei
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human hepatocyte transplantation for liver disease treatment have been hampered by the lack of quality human hepatocytes. Pigs with their large body size, longevity and physiological similarities with human are appropriate animal models for the in vi
Externí odkaz:
https://doaj.org/article/e5849c3a976a4583a09e3ffa87cb33e0
Autor:
Julia J. Reichwald, Frederic Risch, Anna-Lena Neumann, Stefan J. Frohberger, Johanna F. Scheunemann, Benjamin Lenz, Alexandra Ehrens, Wiebke Strutz, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Group 2 innate lymphoid cells (ILC2s) are inducers of type 2 immune responses, but their role during filarial infection remains unclear. In the present study, we used the Litomosoides sigmodontis rodent model of filariasis to analyze ILC2s during inf
Externí odkaz:
https://doaj.org/article/1acc41176560467e8afe08d122c37d69