Refinement as ethics principle in animal research: Is it necessary to standardize the Environmental enrichment in laboratory animals?

Autor: MARTA L. FISCHER, GABRIELA S. RODRIGUES, WINDY P. AGUERO, RAFAEL ZOTZ, DAIANE P. SIMÃO-SILVA

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 93, Iss 1 (2021)

Abstract The Environmental enrichment technique, although scientifically recognized for raising the level of animal welfare, has led to the questioning of its influence on the results of experimental research. Thus, the goal is to promote reflection

Externí odkaz: https://doaj.org/article/42852a730c944870859eb9e837be9116

The development of a mechanical device to stretch skeletal muscle of young and old rats

Autor: Talita Gianello Gnoato Zotz, Rafael Zotz, Ana Tereza Bittencourt Guimarães, Eduard Goossen, Anna Raquel Silveira Gomes

Publikováno v: Clinics, Vol 74

OBJECTIVE: How much force is needed to stretch skeletal muscle is still unknown. The aim of this study was to develop a device that mechanically stretches rat muscle to compare the force (N) required to stretch the soleus muscle of young and aged rat

Externí odkaz: https://doaj.org/article/a1f81f222812497985588e8a2f6d274b

Refinement as ethics principle in animal research: Is it necessary to standardize the Environmental enrichment in laboratory animals?

Autor: Rafael Zotz, Windy Pacheco Aguero, Marta Luciane Fischer, Daiane Priscila Simão-Silva, Gabriela Santos Rodrigues

Publikováno v: Anais da Academia Brasileira de Ciências, Volume: 93, Issue: 1, Article number: e20191526, Published: 24 MAR 2021
Anais da Academia Brasileira de Ciências, Vol 93, Iss 1 (2021)
Anais da Academia Brasileira de Ciências v.93 n.1 2021
Anais da Academia Brasileira de Ciências
Academia Brasileira de Ciências (ABC)
instacron:ABC

The Environmental enrichment technique, although scientifically recognized for raising the level of animal welfare, has led to the questioning of its influence on the results of experimental research. Thus, the goal is to promote reflection about the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e92d9262397afd5d00663708da9702
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000101102&lng=en&tlng=en

Inhalation therapy with M1 inhibits experimental melanoma development and metastases in mice

Autor: Lucas Ferrari de Andrade, Carolina Camargo de Oliveira, Dorly de Freitas Buchi, Fernando de Souza Fonseca Guimarães, Aline Raquell Leck, Edvaldo S. Trindade, Gustavo Rodrigues Rossi, Cleber Rafael Vieira da Costa, Brian Mozeleski, Katia Fialho do Nascimento, Rafael Zotz

Publikováno v: Homeopathy. 105:109-118

Background M1 is a homeopathic medicine with immunostimulatory properties used mainly by cancer patients to complement current therapies. Metastatic melanoma is a skin-originated form of cancer without a single therapy able to produce high rate and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff1770a24ba4b21a1b5bb39ceff59d1
https://doi.org/10.1016/j.homp.2015.08.007

Morphometric and Molecular Muscle Remodeling after Passive Stretching in Elderly Female Rats

Autor: Marina Louise Viola De Azevedo, Luiz Guilherme Achcar Capriglione, Lucia de Noronha, Sabrina Peviani Messa, Hilana Rickli Fiuza Martins, Rafael Zotz, Talita Gianello Gnoato Zotz, Anna Raquel Silveira Gomes

Publikováno v: Clinics
Clinics, Volume: 75, Article number: e1769, Published: 27 NOV 2020
Clinics, Vol 75 (2020)

OBJECTIVES: To determine the effects of three sessions of a passive stretching exercise protocol on the muscles of elderly female rats. METHODS: The effects of the stretching exercises on the soleus muscle were analyzed using immunohistochemistry [ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15e364580d657ed7411aa39350ec66c
https://doi.org/10.6061/clinics/2020/e1769