Výsledky vyhledávání - "RAFAEL R. DIHL"

Akademický článek

In vitro and in silico assessment of cytotoxicity and chromosome instability induced by saxitoxin in human derived neural cell line

Autor: JULIANY S. CONSTANTE, JULIANA E. AL KHATEEB, ANA PAULA DE SOUZA, FELIPE U. CONTER, MAURÍCIO LEHMANN, JOÃO S. YUNES, RAFAEL R. DIHL

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 94, Iss suppl 4 (2022)

Abstract In freshwater, saxitoxins (STX) are produced by different cyanobacteria genera, including Raphidiopsis. Data regarding cytogenotoxicity effects of STX on human cells are scarse, this merit further studies of its toxicology. This study assess

Externí odkaz: https://doaj.org/article/0cb8d9787f264514b41570d908d5a093

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Akademický článek

Evaluation of the genetic toxicity of sofosbuvir and simeprevir with and without ribavirin in a human-derived liver cell line

Autor: CARINA S. LIBRELOTTO, ANA PAULA DE SOUZA, MÁRIO R. ÁLVARES-DA-SILVA, DANIEL SIMON, RAFAEL R. DIHL

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 93, Iss 4 (2021)

Abstract Direct-acting antivirals have revolutionized the treatment of chronic hepatitis C. Sofosbuvir and simeprevir are prescribed worldwide. However, there is a scarcity of information regarding their genotoxicity. Therefore, the present study ass

Externí odkaz: https://doaj.org/article/c22e7178303c4ee4b48e809517429bfe

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Akademický článek

Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster

Autor: LEONARDO P. FRANCHI, NILZA N. GUIMARAES, LAISE R. DE ANDRADE, HELOISA H.R. DE ANDRADE, MAURICIO LEHMANN, RAFAEL R. DIHL, KENYA S. CUNHA

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 85, Iss 2, Pp 585-594 (2013)

Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice

Externí odkaz: https://doaj.org/article/78c8715d1aac40e8b79700a8f9be114f

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Akademický článek

Micronuclei induced by reverse transcriptase inhibitors in mononucleated and binucleated cells as assessed by the cytokinesis-block micronucleus assay

Autor: Eloir D. Lourenço, Viviane S. do Amaral, Mauricio Lehmann, Rafael R. Dihl, Virginia M. Schmitt, Kênya S. Cunha, Maria L. Reguly, Heloisa H.R. de Andrade

Publikováno v: Genetics and Molecular Biology, Vol 33, Iss 4, Pp 756-760 (2010)

This study evaluated the clastogenic and/or aneugenic potential of three nucleoside reverse transcriptase inhibitors (zidovudine - AZT, lamivudine - 3TC and stavudine - d4T) using the cytokinesis-block micronucleus (CBMN) assay in human lymphocyte cu

Externí odkaz: https://doaj.org/article/482c9b2aecd9404ab7b9b5304a1b829c

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