Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity

Autor: Longo M, RACITI GA, Zatterale F, Parrillo L, DESIDERIO, ANTONELLA, Spinelli R, Hammarstedt A, Hedjazifar S, Hoffmann JM, Nigro C, Mirra P, Fiory F, Formisano P, Miele C, Smith U, Beguinot F, LM and RGA contributed equally to this work.

Publikováno v: Diabetologia
Diabetologia (Berl.) 61 (2018): 369–380. doi:10.1007/s00125-017-4471-4
info:cnr-pdr/source/autori:Longo M.; Raciti G.A.; Zatterale F.; Parrillo L.; Desiderio A.; Spinelli R.; Hammarstedt A.; Hedjazifar S.; Hoffmann J.M.; Nigro C.; Mirra P.; Fiory F.; Formisano P.; Miele C.; Smith U.; Beguinot F./titolo:Epigenetic modifications of the Zfp%2FZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity/doi:10.1007%2Fs00125-017-4471-4/rivista:Diabetologia (Berl.)/anno:2018/pagina_da:369/pagina_a:380/intervallo_pagine:369–380/volume:61

Aims/hypothesis Subcutaneous adipocyte hypertrophy is associated with insulin resistance and increased risk of type 2 diabetes, and predicts its future development independent of obesity. In humans, subcutaneous adipose tissue hypertrophy is a conseq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedb93fc0a48212a3122516b919c75e0
http://europepmc.org/articles/PMC6448963

GRP78 mediates cell growth and invasiveness in endometrial cancer

Autor: Calì G, Insabato L, Conza D, Bifulco G, Parrillo L, Mirra P, Fiory F, Miele C, RACITI GA, Di Jeso B, Terrazzano G, Beguinot F, Ulianich L, BIFULCO, GIUSEPPE

Recent studies have indicated that endoplasmic reticulum stress, the unfolded protein response activation and altered GRP78 expression can play an important role in a variety of tumors development and progression. Very recently we reported for the fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::e3b02c4386ad7457e3fc264dd586c219
http://hdl.handle.net/11588/575386

PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells

Autor: Miele C, RACITI GA, Cassese A, Romano C, Giacco F, Oriente F, Paturzo F, Andreozzi F, Zabatta A, Troncone G, Bosch F, Pujol A, Chneiweiss H, Formisano P, Beguinot F, MC and RGA contributed equally to this work.

The phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (ped/pea-15) gene is overexpressed in human diabetes and causes this abnormality in mice. Transgenic mice with beta-cell-specific overexpression of ped/pea-15 (beta-tg) exh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2991096167629f0335be1c77e71150
http://hdl.handle.net/11588/203950

Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED/PEA-15

Autor: Cassese A, Raciti GA, Fiory F, Nigro C, Ulianich L, Castanò I, D'Esposito V, Terracciano D, Pastore L, Formisano P, Beguinot F, Miele C.

Publikováno v: PloS one (2013).
info:cnr-pdr/source/autori:Cassese A, Raciti GA, Fiory F, Nigro C, Ulianich L, Castanò I, D'Esposito V, Terracciano D, Pastore L, Formisano P, Beguinot F, Miele C./titolo:Adenoviral Gene Transfer of PLD1-D4 Enhances Insulin Sensitivity in Mice by Disrupting Phospholipase D1 Interaction with PED%2FPEA-15./doi:/rivista:PloS one/anno:2013/pagina_da:/pagina_a:/intervallo_pagine:/volume

Over-expression of phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (PED/PEA-15) causes insulin resistance by interacting with the D4 domain of phospholipase D1 (PLD1). Indeed, the disruption of this association restores insu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::68f066c26394812c941699fec76063d4
https://publications.cnr.it/doc/209736

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