Zobrazeno 1 - 10
of 177
pro vyhledávání: '"R6/2 mice"'
Publikováno v:
Cells, Vol 13, Iss 6, p 469 (2024)
Huntington’s disease (HD), a congenital neurodegenerative disorder, extends its pathological damages beyond the nervous system. The systematic manifestation of HD has been extensively described in numerous studies, including dysfunction in peripher
Externí odkaz:
https://doaj.org/article/68c0c184414a4ba697ff84266ce72fe3
Autor:
Roberto Speziale, Camilla Montesano, Giulia Di Pietro, Daniel Oscar Cicero, Vincenzo Summa, Edith Monteagudo, Laura Orsatti
Publikováno v:
Metabolites, Vol 13, Iss 8, p 961 (2023)
Huntington’s disease (HD) is caused by the expansion of a polyglutamine (polyQ)-encoding tract in exon 1 of the huntingtin gene to greater than 35 CAG repeats. It typically has a disease course lasting 15–20 years, and there are currently no dise
Externí odkaz:
https://doaj.org/article/7a92756f06cd4e50be6195e730b03141
Autor:
Libo Yu-Taeger, Arianna Novati, Jonasz Jeremiasz Weber, Elisabeth Singer-Mikosch, Ann-Sophie Pabst, Fubo Cheng, Carsten Saft, Jennifer Koenig, Gisa Ellrichmann, Taneli Heikkinen, Mahmoud A. Pouladi, Olaf Riess, Huu Phuc Nguyen
Publikováno v:
Cells, Vol 11, Iss 23, p 3779 (2022)
Body weight (BW) loss and reduced body mass index (BMI) are the most common peripheral alterations in Huntington disease (HD) and have been found in HD mutation carriers and HD animal models before the manifestation of neurological symptoms. This sug
Externí odkaz:
https://doaj.org/article/182d9543377f43cc8144fbbfc702c74e
Autor:
Ido Rippin, Katherina Bonder, Shirley Joseph, Ammar Sarsor, Lilach Vaks, Hagit Eldar-Finkelman
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105336- (2021)
In Huntington's disease (HD), the mutant huntingtin (mHtt) accumulates as toxic aggregates in the striatum tissue, with deleterious effects on motor-coordination and cognitive functions. Reducing the levels of mHtt is therefore a promising therapeuti
Externí odkaz:
https://doaj.org/article/046c34e9ec654364a9ccf8bd0fb54142
Publikováno v:
Neurobiology of Disease, Vol 155, Iss , Pp 105374- (2021)
Background: Huntington's disease (HD) starts its pathology long before clinical manifestation, however, there is no therapy to cure it completely and only a few studies have been reported for delaying the progression of HD. Recently, it has been show
Externí odkaz:
https://doaj.org/article/d3a489523f5349a3ba814f8879176765
Akademický článek
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Autor:
A. Di Pardo, G. Pepe, L. Capocci, F. Marracino, E. Amico, L. Del Vecchio, S. Giova, S.K. Jeong, B.M. Park, B.D. Park, V. Maglione
Publikováno v:
Neurobiology of Disease, Vol 143, Iss , Pp 105009- (2020)
Emerging evidence indicates that Huntington's disease (HD) may be described as multi-organ pathology. In this context, we and others have contributed to demonstrate that the disease is characterized by an impairment of the homeostasis of gastro-intes
Externí odkaz:
https://doaj.org/article/319eb3ff21fc4c9d92a52aab402bc5ac
Autor:
Masashi Fukuoka, Masaki Takahashi, Hiromi Fujita, Tomoko Chiyo, H. Akiko Popiel, Shoko Watanabe, Hirokazu Furuya, Miho Murata, Keiji Wada, Takashi Okada, Yoshitaka Nagai, Hirohiko Hohjoh
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 79-90 (2018)
Huntington’s disease (HD) is an intractable neurodegenerative disorder caused by mutant Huntingtin (HTT) proteins that adversely affect various biomolecules and genes. MicroRNAs (miRNAs), which are functional small non-coding RNAs, are also affecte
Externí odkaz:
https://doaj.org/article/223f3142b53e4d84b5a0fd79dddaa324
Autor:
Jack C. Reidling, Aroa Relaño-Ginés, Sandra M. Holley, Joseph Ochaba, Cindy Moore, Brian Fury, Alice Lau, Andrew H. Tran, Sylvia Yeung, Delaram Salamati, Chunni Zhu, Asa Hatami, Carlos Cepeda, Joshua A. Barry, Talia Kamdjou, Alvin King, Dane Coleal-Bergum, Nicholas R. Franich, Frank M. LaFerla, Joan S. Steffan, Mathew Blurton-Jones, Charles K. Meshul, Gerhard Bauer, Michael S. Levine, Marie-Francoise Chesselet, Leslie M. Thompson
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 58-72 (2018)
Summary: Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment
Externí odkaz:
https://doaj.org/article/6a20e0b98a194e96bbd0862727f88f6d
Akademický článek
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