Zobrazeno 1 - 10
of 160
pro vyhledávání: '"R6/1"'
Autor:
Dashuang Yang, Chunhui Huang, Xuemeng Guo, Yintian Li, Jiaxi Wu, Zaijun Zhang, Sen Yan, Ying Xu
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Huntington’s disease (HD) is a progressive neurodegenerative disorder characterized by motor dysfunction and cognitive decline. While retinal abnormalities have been documented in some HD patients and animal models, the nature of these abnormalitie
Externí odkaz:
https://doaj.org/article/fc57a499e300493b8251de32e4b6221c
Autor:
Ana Fernández, Carmen Martínez-Ramírez, Ana Gómez, Antonio M.G. de Diego, Luis Gandía, María José Casarejos, Antonio G. García
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106046- (2023)
From a pathogenic perspective, Huntington's disease (HD) is being considered as a synaptopathy. As such, alterations in brain neurotransmitter release occur. As the activity of the sympathoadrenal axis is centrally controlled, deficits in the exocyto
Externí odkaz:
https://doaj.org/article/dbeac8af3cda41a28beda3cfb0f2dbce
Autor:
Rodolfo G Gatto, Carina Weissmann
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 5, Pp 983-986 (2022)
During the last decades, advances in the understanding of genetic, cellular, and microstructural alterations associated to Huntington’s disease (HD) have improved the understanding of this progressive and fatal illness. However, events related to e
Externí odkaz:
https://doaj.org/article/48050812e5a24f84b042f385307d8bb3
Autor:
Magdalena Podlacha, Karolina Pierzynowska, Lidia Gaffke, Grażyna Jerzemowska, Ewa Piotrowska, Grzegorz Węgrzyn
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 23, Iss , Pp 100482- (2022)
Background: Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by a triad of cognitive, psychiatric and motor symptoms. One of the main mechanisms of the disease, besides the aggregation of mutant proteins, is the chronic
Externí odkaz:
https://doaj.org/article/9226154a6e494b6d99d986928f2a4dbc
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease
Autor:
Rafael Alcalá‐Vida, Marta Garcia‐Forn, Carla Castany‐Pladevall, Jordi Creus‐Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí‐Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez‐Navarro
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-25 (2020)
Abstract Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorde
Externí odkaz:
https://doaj.org/article/127bba476357472aa2d34c9d8e7f0916
Autor:
Katharina Hecklau, Susanne Mueller, Stefan Paul Koch, Mustafa Hussain Mehkary, Busra Kilic, Christoph Harms, Philipp Boehm-Sturm, Ferah Yildirim
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease characterized by a late clinical onset of psychiatric, cognitive, and motor symptoms. Transcriptional dysregulation is an early and central disease mechanism which is acco
Externí odkaz:
https://doaj.org/article/f9766f01a40d417fa1324980494d2886
Akademický článek
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Autor:
Abraham Rosas-Arellano, Argel Estrada-Mondragón, Carola A Mantellero, Carlos Tejeda-Guzmán, Maite A Castro
Publikováno v:
Neural Regeneration Research, Vol 13, Iss 4, Pp 584-590 (2018)
γ-Aminobutyric acid (GABA), plays a key role in all stages of life, also is considered the main inhibitory neurotransmitter. GABA activates two kind of membrane receptors known as GABAA and GABAB, the first one is responsible to render tonic inhibit
Externí odkaz:
https://doaj.org/article/3228254e5ed4408cb785dab9deba92ec
Akademický článek
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Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease
Autor:
Shiraz Tyebji, Ana Saavedra, Paula M. Canas, Anna Pliassova, José M. Delgado-García, Jordi Alberch, Rodrigo A. Cunha, Agnès Gruart, Esther Pérez-Navarro
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 41-57 (2015)
Stimulation of dopamine D1 receptor (D1R) and adenosine A2A receptor (A2AR) increases cAMP-dependent protein kinase (PKA) activity in the brain. In Huntington's disease, by essentially unknown mechanisms, PKA activity is increased in the hippocampus
Externí odkaz:
https://doaj.org/article/ef6f5f933eed4929acfdd4a83b353a0c