Zobrazeno 1 - 10
of 2 830
pro vyhledávání: '"R6/1"'
The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice
Autor:
Espina, Marc, Di Franco, Nadia, Brañas-Navarro, Martina, Navarro, Irene Rodriguez, Brito, Veronica, Lopez-Molina, Laura, Costas-Insua, Carlos, Guzmán, Manuel, Ginés, Silvia
Publikováno v:
In Neurobiology of Disease August 2023 184
Autor:
Ana Fernández, Carmen Martínez-Ramírez, Ana Gómez, Antonio M.G. de Diego, Luis Gandía, María José Casarejos, Antonio G. García
Publikováno v:
Neurobiology of Disease, Vol 179, Iss , Pp 106046- (2023)
From a pathogenic perspective, Huntington's disease (HD) is being considered as a synaptopathy. As such, alterations in brain neurotransmitter release occur. As the activity of the sympathoadrenal axis is centrally controlled, deficits in the exocyto
Externí odkaz:
https://doaj.org/article/dbeac8af3cda41a28beda3cfb0f2dbce
Autor:
Fernández, Ana, Martínez-Ramírez, Carmen, Gómez, Ana, de Diego, Antonio M.G., Gandía, Luis, Casarejos, María José, García, Antonio G.
Publikováno v:
In Neurobiology of Disease April 2023 179
Autor:
Rodolfo G Gatto, Carina Weissmann
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 5, Pp 983-986 (2022)
During the last decades, advances in the understanding of genetic, cellular, and microstructural alterations associated to Huntington’s disease (HD) have improved the understanding of this progressive and fatal illness. However, events related to e
Externí odkaz:
https://doaj.org/article/48050812e5a24f84b042f385307d8bb3
Autor:
Rodríguez-Urgellés, Ened, Rodríguez-Navarro, Irene, Ballasch, Iván, del Toro, Daniel, del Castillo, Ignacio, Brito, Verónica, Alberch, Jordi, Giralt, Albert
Publikováno v:
In Neurobiology of Disease 15 October 2022 173
Autor:
Ochaba, Joseph, Fote, Gianna, Kachemov, Marketta, Thein, Soe, Yeung, Sylvia Y., Lau, Alice L., Hernandez, Sarah, Lim, Ryan G., Casale, Malcolm, Neel, Michael J., Monuki, Edwin S., Reidling, Jack, Housman, David E., Thompson, Leslie M., Steffan, Joan S.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2019 May . 116(22), 10952-10961.
Externí odkaz:
https://www.jstor.org/stable/26707168
Autor:
Podlacha, Magdalena, Pierzynowska, Karolina, Gaffke, Lidia, Jerzemowska, Grażyna, Piotrowska, Ewa, Węgrzyn, Grzegorz
Publikováno v:
In Brain, Behavior, & Immunity - Health August 2022 23
Publikováno v:
In Neuroscience Letters 10 January 2022 767
Autor:
Magdalena Podlacha, Karolina Pierzynowska, Lidia Gaffke, Grażyna Jerzemowska, Ewa Piotrowska, Grzegorz Węgrzyn
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 23, Iss , Pp 100482- (2022)
Background: Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by a triad of cognitive, psychiatric and motor symptoms. One of the main mechanisms of the disease, besides the aggregation of mutant proteins, is the chronic
Externí odkaz:
https://doaj.org/article/9226154a6e494b6d99d986928f2a4dbc
The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice
Autor:
Marc Espina, Nadia Di Franco, Martina Brañas-Navarro, Irene Rodriguez Navarro, Veronica Brito, Laura Lopez-Molina, Carlos Costas-Insua, Manuel Guzmán, Silvia Ginés
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106225- (2023)
Increasing evidence indicates that a key factor in neurodegenerative diseases is the activation of the unfolded protein response (UPR) caused by an accumulation of misfolded proteins in the endoplasmic reticulum (ER stress). Particularly, in Huntingt
Externí odkaz:
https://doaj.org/article/ede8d1825f004ae789741daebb76f3ed