Zobrazeno 1 - 10
of 22
pro vyhledávání: '"R.W. Suchomel"'
Autor:
Robert Pirker, Martin Filipits, R.W. Suchomel, Klaus Geissler, Rik J. Scheper, Klaus Lechner, Thomas Stranzl, Ulrich Jäger, Gudrun Pohl
Publikováno v:
Blood. 91:1508-1513
The 110-kD lung resistance protein (LRP) is overexpressed in P-glycoprotein–negative multidrug-resistant cell lines and most likely involved in the multidrug resistance (MDR) of these cell lines. To determine the clinical significance of LRP, we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c30cf77d52f13a224b00f9d7e0b571ef
https://doi.org/10.1182/blood.v91.5.1508
https://doi.org/10.1182/blood.v91.5.1508
Autor:
Robert Pirker, M Fillpits, Wolfgang Stiglbauer, R.W. Suchomel, Gerhard Dekan, K. Haider, D. Depisch
Publikováno v:
British Journal of Cancer
To determine the clinical significance of MRP in patients with colorectal carcinomas, we have studied the expression of the MRP gene by reverse transcription-polymerase chain reaction (RT-PCR) (n = 105) and by immunohistochemistry (n = 30). MRP mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfbe0af1a5787cc9780331fd0d848a9
https://doi.org/10.1038/bjc.1997.35
https://doi.org/10.1038/bjc.1997.35
Publikováno v:
Leukemia & Lymphoma. 23:451-458
Drug resistance often results in failure of anticancer chemotherapy in leukemias. Several mechanisms of drug resistance are known with multidrug resistance (MDR) being the best characterized one. MDR can be due to enhanced expression of certain genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd34dbc28adfe580c5a45b3958e4004
https://doi.org/10.3109/10428199609054853
https://doi.org/10.3109/10428199609054853
Autor:
Klaus Lechner, S. Zöchbauer, Gudrun Pohl, Raoul Brunner, Martin Filipits, R.W. Suchomel, Thomas Stranzl, Robert Pirker
Publikováno v:
Drug Resistance in Leukemia and Lymphoma III ISBN: 9781461371809
To determine the clinical significance of the multidrug resistance protein (MRP) in patients with de novo AML, we have studied MRP expression of leukemic cells at diagnosis and its association with clinical outcome in 127 patients. MRP expression was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97ce4f17dcf55bf04ff305ac20124de6
https://doi.org/10.1007/978-1-4615-4811-9_16
https://doi.org/10.1007/978-1-4615-4811-9_16
Autor:
Klaus Lechner, R.W. Suchomel, Gudrun Pohl, Ulrich Jäger, Thomas Stranzl, Robert Pirker, Rik J. Scheper, Martin Filipits, Klaus Geissler
Publikováno v:
Drug Resistance in Leukemia and Lymphoma III ISBN: 9781461371809
To determine the clinical significance of the lung resistance protein (LRP) in acute myeloid leukemia (AML), we have studied LRP expression of leukemic blasts and its association with clinical outcome in patients with de novo AML. LRP expression of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d7a88dc3c658706240a5e6c3378cd6
https://doi.org/10.1007/978-1-4615-4811-9_15
https://doi.org/10.1007/978-1-4615-4811-9_15
Publikováno v:
Leukemia. 11(7)
Immunocytochemical detection of the expression of the MRP gene and the MDR1 gene in clinical specimens might be affected by several factors. Thus, we studied the impact of monoclonal antibodies, sample source (peripheral blood vs bone marrow) and dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be28b8d6510efaf3939f0499f38660bf
https://pubmed.ncbi.nlm.nih.gov/9204994
https://pubmed.ncbi.nlm.nih.gov/9204994
Publikováno v:
European Journal of Cancer. 32:S29
Multidrug-resistance (MDR) can be due to the overexpression of the MDRl gene or the multidrug-resistance associated protein (MRP) gene. In addition, alterations In the expression and activity of glutathione-S-transferase π (GSTπ) can cause MDR. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fb2213364d312012335c653ee127316
https://doi.org/10.1016/0959-8049(96)84904-5
https://doi.org/10.1016/0959-8049(96)84904-5
Autor:
Martin Filipits, H. Huber, Gerhard Dekan, G. Valdimarsson, R.W. Suchomel, Robert Pirker, K. Haider, D. Depisch
Publikováno v:
European Journal of Cancer. 32:S19
To assess the clinically important mechanisms of drug resistance in breast cancer, we detennined the expression of the MRP and MDR1 genes in primary breast carcinoma specimens. Using RT-PCR, MRP RNA was detected in all specimens and MDR1 RNA in only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196e876fb8ec1b94c57fa8d0c7375ab8
https://doi.org/10.1016/0959-8049(96)84850-7
https://doi.org/10.1016/0959-8049(96)84850-7
Autor:
R.W. Suchomel, Martin Filipits, H. Huber, S. Zöchbauer, D. Depiseh, R. Picker, K. Haider, Josef Wallner
Publikováno v:
European Journal of Cancer. 32:S29
The MDRI gene, a multidrug resistance gene, is frequently expressed in colorectal carcinomas. To determine whether this expression is of prognostic value, we determined the relationship between MDRI gene expression of primary colorectal carcinomas an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fe2634d9127f803ea2131c4c9588812
https://doi.org/10.1016/0959-8049(96)84902-1
https://doi.org/10.1016/0959-8049(96)84902-1
Publikováno v:
European Journal of Cancer. 31:S31
To determine the clinically important mechanisms of multidrug resistance, we studied the expression of the MRP gene in primary colorectal carcinomas (N = 75). MRP RNA was determined by RT-PCR. MRP RNA was detected in 62 (83%) tumor specimens. The exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e373a963705f57f78269337579d325ed
https://doi.org/10.1016/0959-8049(95)95387-l
https://doi.org/10.1016/0959-8049(95)95387-l