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Autor:
John R. Fozard, Roger C. Small, K. Archer, Andrew J. Miller, A. Martin, K.H. Buchheit, Keith R.F. Elliott, S.J. Cook, T. Müller, R.W. Foster
Publikováno v:
British Journal of Pharmacology. 114:143-151
1. SCA40 (1nM-10 microM), isoprenaline (1-300 nM) and levcromakalim (100 nM-10 microM) each produced concentration-dependent suppression of the spontaneous tone of guinea-pig isolated trachea. Propranolol (1 microM) markedly (approximately 150 fold)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1148b57f6eb169b94ccd5cb0716ac88
https://doi.org/10.1111/j.1476-5381.1995.tb14918.x
https://doi.org/10.1111/j.1476-5381.1995.tb14918.x
Autor:
Roger C. Small, L. Vernillet, A. S. Jubber, R.W. Foster, B. Franke, N. A. G. M. Hassan, J.R. Carpenter, J. Denouel
Publikováno v:
European Journal of Clinical Pharmacology. 45:227-234
An approximately steady-state reduction of specific airway conductance was induced in healthy human subjects by means of an individualized inhaled methacholine loading dose followed by a maintenance dose regime. Tested against this background broncho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dfbe1baa4c5b7de2225582c6575c5f
https://doi.org/10.1007/bf00315388
https://doi.org/10.1007/bf00315388
Publikováno v:
British Journal of Pharmacology. 109:1140-1148
1. Mechanical and electrophysiological studies of guinea-pig isolated trachealis have been made with the objectives of: (a) identifying which of the beta-adrenoceptor subtypes mediates the opening of plasmalemmal K(+)-channels, (b) gaining further in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b99c8fa9f569bae62db250c59a0e29
https://doi.org/10.1111/j.1476-5381.1993.tb13741.x
https://doi.org/10.1111/j.1476-5381.1993.tb13741.x
Publikováno v:
Pulmonary Pharmacology. 6:49-62
Summary: Freshly-dispersed bovine trachealis cells were used for recording by the patch clamp technique of whole-cell and unitary currents through Ca 2+ -channels. Whole-cell Ca 2+ -current (I Ca ) activated at -40 mV and appeared to be carried by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96d65eac5241fce6876c294d994e49a
https://doi.org/10.1006/pulp.1993.1008
https://doi.org/10.1006/pulp.1993.1008
Publikováno v:
British Journal of Pharmacology. 106:813-818
1. We have studied the ability of some adrenergic neurone blocking agents to inhibit the tracheal relaxant actions of isoprenaline, theophylline and the potassium channel openers (KCOs) BRL 38227, pinacidil and RP 52891. 2. BRL 38227, isoprenaline, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604014f885829447cfd9f6b472385db3
https://doi.org/10.1111/j.1476-5381.1992.tb14417.x
https://doi.org/10.1111/j.1476-5381.1992.tb14417.x
Publikováno v:
European Journal of Pharmacology. 219:81-88
SDZ PCO 400 (30 nM-100 microM) suppressed the spontaneous tone of guinea-pig isolated trachealis. Glibenclamide (1-10 microM), phentolamine (100 microM), guanethidine (50 microM) and bretylium (50 microM) each antagonized SDZ PCO 400 without antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9616c419f3067edbda9040e3287f3c
https://doi.org/10.1016/0014-2999(92)90583-p
https://doi.org/10.1016/0014-2999(92)90583-p
Autor:
Jacqueline L. Berry, K.A. Green, Roger C. Small, S.J. Cook, R.W. Foster, Malcolm Murray, John F. Burka
Publikováno v:
Clinical Experimental Allergy. 22:11-18
The cromakalim-like KCOs relax airways smooth muscle by an action that is associated with the opening of plasmalemmal K(+)-channels. The K(+)-channel involved may be analogous to the ATP-sensitive K(+)-channel identified in pancreatic beta-cells. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67524e945539fab985e05df31b8436a
https://doi.org/10.1111/j.1365-2222.1992.tb00109.x
https://doi.org/10.1111/j.1365-2222.1992.tb00109.x
Publikováno v:
British Journal of Pharmacology. 104:263-269
1. The ability of cromakalim to modulate several different types of neuroeffector transmission has been assessed in guinea-pig isolated trachea. 2. In trachea treated with propranolol (10(-6) M) and indomethacin (2.8 x 10(-6) M), stimulation of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ba534b0f429eec12a70520d0e31add
https://doi.org/10.1111/j.1476-5381.1991.tb12417.x
https://doi.org/10.1111/j.1476-5381.1991.tb12417.x
Publikováno v:
British Journal of Pharmacology. 103:1814-1818
1 A study has been made, in guinea-pig isolated trachealis, of the effects of charybdotoxin in modulating (a) the activity of large conductance K+-channels, (b) the spontaneous electrical activity of intact cells and (c) the mechanical effects of som
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdce90a6c43596728dc42f4118a16b60
https://doi.org/10.1111/j.1476-5381.1991.tb09868.x
https://doi.org/10.1111/j.1476-5381.1991.tb09868.x