Zobrazeno 1 - 10
of 98
pro vyhledávání: '"R.W. Brimblecombe"'
Autor:
Denise Youngs, David L. Morris, R.W. Brimblecombe, T J Muscroft, Joan Barnard, P.M.G. Bavin, D W Darkin, Mrb Keighley, V. Poxon, D. W. Burdon
Publikováno v:
Gut. 25:238-245
Three groups of patients studied after operations which had cured their duodenal ulcer were compared with a control group (no operation, n = 8). The surgical procedures included: proximal gastric vagotomy (n = 7), truncal vagotomy and pyloroplasty (n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6371e61f11fb2fce130d1f884616e501
https://doi.org/10.1136/gut.25.3.238
https://doi.org/10.1136/gut.25.3.238
Autor:
P.J. Moore, P.M.G. Bavin, N.F. Lightfoot, Z. Ahmet, N. Viney, G J Milton-Thompson, D. Darkin, R.W. Brimblecombe, Joan Barnard, Richard H. Hunt
Publikováno v:
The Lancet. 319:1091-1095
Eight healthy subjects were studied half-hourly or hourly for 24 h periods before, during, and after cimetidine treatment. No significant differences in intragastric bacterial counts or bacterial species or in intragastric nitrite or N-nitroso-compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493e202c874e3d047ba6de15afd99862
https://doi.org/10.1016/s0140-6736(82)92277-2
https://doi.org/10.1016/s0140-6736(82)92277-2
Publikováno v:
General Pharmacology: The Vascular System. 10:489-497
1. Experiments in mice with Cycloheximide (CXM) helped to elucidate some of the underlying mechanisms involved in learning and memory. 2. It appeared that there were consolidation processes occurring whereby short-term memory (STM) was converted into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1f80f78a180d2159c22f62737b011d
https://doi.org/10.1016/0306-3623(79)90014-4
https://doi.org/10.1016/0306-3623(79)90014-4
Publikováno v:
Burns. 3:8-13
A study has been made of the effect of histamine H 2 -receptor antagonists on thermal injury in rat bind paws produced by immersion in water at 56°C for 30 seconds. Cimetidine caused dose-dependent suppression of thermal oedema when administered bef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3679f18922e1fcc487c4d35eb57931
https://doi.org/10.1016/0305-4179(76)90004-8
https://doi.org/10.1016/0305-4179(76)90004-8
Autor:
R.W. Brimblecombe
Publikováno v:
Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology. 3:65-74
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf3496537ae7a23e3fe200a4aa1f90e
https://doi.org/10.1016/0306-039x(77)90004-6
https://doi.org/10.1016/0306-039x(77)90004-6
Publikováno v:
Human Toxicology. 4:13-25
1 Cimetidine has been shown to have low acute toxicity in dogs and rodents. Repeated-dose studies of up to 24 months' duration in rodents at doses up to 950 mg day kg-1 showed few adverse effects. Liver weight was consistently increased at the highes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded238e6caa8d0ec6a125d104585bbe7
https://doi.org/10.1177/096032718500400103
https://doi.org/10.1177/096032718500400103
Autor:
R.W. Brimblecombe
Publikováno v:
Journal of Pharmacological Methods. 2:91-96
The peculiar sensitivity of the nervous system to a wide variety of chemical substances indicates the need to introduce techniques that are capable of detecting, at an early stage, untoward effects on that system. Behavioral techniques, suitable for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4172170d120b24e5e85efc33be045c0c
https://doi.org/10.1016/0160-5402(79)90043-3
https://doi.org/10.1016/0160-5402(79)90043-3
Autor:
R.W. Brimblecombe, D.M. Green
Publikováno v:
International Journal of Neuropharmacology. 6:133-142
Summary The peripheral anticholinergic activity of imipramine, amitriptyline and their demethylated derivatives has been measured. The activity of the drugs in elevating the EEG arousal threshold in cat encephale isole preparations and in conscious c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2c8d27e0fe6b4c6817e8e43a9128c7b
https://doi.org/10.1016/0028-3908(67)90062-7
https://doi.org/10.1016/0028-3908(67)90062-7
Publikováno v:
Neuropharmacology. 10:93-101
Triflupromazine was found to potentiate the actions of six anticholinergic drugs in producing elevation of EEG arousal thresholds, and dissociation between EEG and behavioural arousal thresholds, in cat encephale isole preparations. The effects of tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5eee565ff8715c75f1b1fa539d5d470
https://doi.org/10.1016/0028-3908(71)90012-8
https://doi.org/10.1016/0028-3908(71)90012-8
Autor:
R.W. Brimblecombe
Publikováno v:
International Journal of Neuropharmacology. 6:423-429
The effects of thirty-six tryptamine derivatives upon the rectal temperature of rabbits and the open-field behaviour of rats are described. Nine compounds were without effect in either test, a further five evoked behavioural changes in the open-field
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8deafbf86018e70c04604f9386bfa43
https://doi.org/10.1016/0028-3908(67)90034-2
https://doi.org/10.1016/0028-3908(67)90034-2