WASP integrates substrate topology and cell polarity to guide neutrophil migration

Autor: Rachel M. Brunetti, Gabriele Kockelkoren, Preethi Raghavan, George R.R. Bell, Derek Britain, Natasha Puri, Sean R. Collins, Manuel D. Leonetti, Dimitrios Stamou, Orion D. Weiner

Publikováno v: Brunetti, R M, Kockelkoren, G, Raghavan, P, Bell, G R R, Britain, D, Puri, N, Collins, S R, Leonetti, M D, Stamou, D & Weiner, O D 2022, ' WASP integrates substrate topology and cell polarity to guide neutrophil migration ', Journal of Cell Biology, vol. 221, no. 2, e202104046 . https://doi.org/10.1083/jcb.202104046
The Journal of cell biology, vol 221, iss 2

To control their movement, cells need to coordinate actin assembly with the geometric features of their substrate. Here, we uncover a role for the actin regulator WASP in the 3D migration of neutrophils. We show that WASP responds to substrate topolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737b4acf3174f8324ab190368a42c1fc
https://curis.ku.dk/ws/files/309279317/jcb_202104046.pdf

Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial

Autor: Petrylak, D.P. de Wit, R. Chi, K.N. Drakaki, A. Sternberg, C.N. Nishiyama, H. Castellano, D. Hussain, S.A. Fléchon, A. Bamias, A. Yu, E.Y. van der Heijden, M.S. Matsubara, N. Alekseev, B. Necchi, A. Géczi, L. Ou, Y.-C. Coskun, H.S. Su, W.-P. Bedke, J. Gakis, G. Percent, I.J. Lee, J.-L. Tucci, M. Semenov, A. Laestadius, F. Peer, A. Tortora, G. Safina, S. Garcia del Muro, X. Rodriguez-Vida, A. Cicin, I. Harputluoglu, H. Tagawa, S.T. Vaishampayan, U. Aragon-Ching, J.B. Hamid, O. Liepa, A.M. Wijayawardana, S. Russo, F. Walgren, R.A. Zimmermann, A.H. Hozak, R.R. Bell-McGuinn, K.M. Powles, T. Wong, S.-L.S. Tan, T.H. Hovey, E.J. Clay, T.D. Wan Ng, S.S. Rutten, A. Machiels, J.-P. Dumez, H. Cheng, S.Y.-S. Ferrario, C. Sengeloev, L. Jensen, N.V. Thibault, C. Laguerre, B. Joly, F. Culine, S. Becht, C. Niegisch, G. Stöckle, M. Grimm, M.-O. Schwentner, C.A. Schultze-Seemann, W. Kalofonos, H. Mavroudis, D. Papandreou, C. Karavasilis, V. Révész, J. Rosenbaum, E. Leibowitz-Amit, R. Kejzman, D. Sarid, D. Scagliotti, G.V. Bracarda, S. Massari, F. Osawa, T. Miyajima, N. Shinohara, N. Fukuta, F. Ohyama, C. Obara, W. Yamashita, S. Tomita, Y. Kawai, K. Fukasawa, S. Oyama, M. Yonese, J. Nagata, M. Uemura, M. Nishimura, K. Kawakita, M. Tsunemori, H. Hashine, K. Inokuchi, J. Yokomizo, A. Nagamori, S. Lee, H.J. Park, S.H. Rha, S.Y. Kim, Y.J. Lee, Y.-G. Vazquez Cortés, L. Lorena Urzua Flores, C. Blaisse, R.J.B. Erdkamp, F.L.G. Aarts, M.J.B. Wojcik-Tomaszewska, J. Tomczak, P. Sikora-Kupis, B. Schenker, M. Herzal, A.A. Udrea, A.A. Karlov, P. Fomkin, R. Gajate Borau, P. Grande, E. Delgado Mignorance, J.I. Su, Y.-L. Li, J.-R. Lin, C.-L. Lin, C.-C. Yeh, S.-P. Erman, M. Urun, Y. Golovko, Y. Bondarenko, I. Sinielnikov, I. Crabb, S.J. Syndikus, I. Huddart, R. Sundar, S. Chowdhury, S. Sarwar, N. Flaig, T.W. Pan, C.X. Schwarz, J.K. Cultrera, J.L. Acs, P.I. Hainsworth, J.D. Herms, B.T. Lawler, W.E. Lowe, T.E.

Background: Ramucirumab—an IgG1 vascular endothelial growth factor receptor 2 antagonist—plus docetaxel was previously reported to improve progression-free survival in platinum-refractory, advanced urothelial carcinoma. Here, we report the second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::6d6c203046c19aaa2c6364316d7bcd5b
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3105243

Effect of in vitro treatment of rat hepatocytes with selenium, and/or cadmium on cell viability, glucose output, and cellular glutathione

Autor: Magdi R.I. Soliman, Johnnie L. Early, Vani K. Nonavinakere, R.R. Bell

Publikováno v: Toxicology. 69:111-119

The effects of cadmium as cadmium acetate and selenium as sodium selenite on glucose output, cell viability, and glutathione levels in rat hepatocytes were evaluated. Isolated hepatocytes (200 mg wet wt cells) derived from naive male Sprague--Dawley

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c1d3a7b00baeabb01d40919cec6877
https://doi.org/10.1016/0300-483x(91)90224-o

Expression of cyclooxygenase-2 in embryonic and fetal tissues during organogenesis and late pregnancy

Autor: R.R. Bell, K.M. Stanfield, K. Nasir M. Khan, S.S. Saldeen, A.R. Lisowski, M.L. English

Publikováno v: Birth defects research. Part A, Clinical and molecular teratology. 67(1)

BACKGROUND Cyclooxygenase (COX) catalyzes the committed step in prostaglandin biosynthesis and exists as two related but unique isoforms, COX-1 (constitutive) and COX-2 (inducible). Prostaglandins (PGs) are known to have many important functions in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa73fd234255b12a2f3da9e5ac055cf
https://pubmed.ncbi.nlm.nih.gov/12749384

Acute effects of cadmium and selenium on glucose output from rat liver hepatocytes using various gluconeogenic precursors

Autor: Magdi R.I. Soliman, R.R. Bell, Johnnie L. Early

Publikováno v: Toxicology. 65(1-2)

Male Sprague-Dawley rats (250-310 g) fasted for 24 h were injected i.p. with either sodium acetate (C2H3NaO2; 1.23 mg/kg, 15 mumol/kg), cadmium acetate (C4H6CdO4; 0.84 mg/kg, 3.6 mumol/kg), sodium selenite (Na2SeO3; 1.6 mg/kg, 9.2 mumol/kg) or cadmiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6f2fd956e5fe350db6c877aecfcb4d
https://pubmed.ncbi.nlm.nih.gov/2274964