A multi nutrient concept to enhance synapse formation and function: science behind a medical food for Alzheimer’s disease

Autor: Martine Groenendijk, R.L. Wieggers, Patrick Joseph Gerardus Hendrikus Kamphuis, John W.C. Sijben, Martijn C. de Wilde

Publikováno v: Oléagineux, Corps gras, Lipides, Vol 18, Iss 5, Pp 267-270 (2011)

Alzheimer’s Disease (AD) is the leading cause of dementia. Epidemiological studies suggest that AD is linked with poor status of nutrients including DHA, B-vitamins and the vitamins E and C. Ongoing neurodegeneration, particularly synaptic loss, le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f1512ebd21f6850bf5c06649dca743
https://doaj.org/article/7299033b3e6147ac8333e9e1825911d2

P4–265: Mechanism of action of the specific nutrient combination Fortasyn® Connect, which is designed to enhance synapse formation and function in Alzheimer's disease

Autor: John W.C. Sijben, Laus M. Broersen, Martine Groenendijk, Nick van Wijk, R.L. Wieggers, Martijn C. de Wilde, Patrick Joseph Gerardus Hendrikus Kamphuis, Robert Johan Joseph Hageman

Publikováno v: Alzheimer's & Dementia. 9

homocysteine levels, which in turn influences the PEMT pathway. This especially is relevant in AD, which is associated with high plasma homocysteine levels and B-vitamin deficiencies. Vitamin C, E, and selenium can serve as antioxidants to protect th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c826abfec63d1a5421bc35d9d64f2e8f
https://doi.org/10.1016/j.jalz.2013.05.1658

The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer's disease

Autor: Joseph F. Quinn, Sue Leurgans, Philip Scheltens, R.L. Wieggers, Patrick Joseph Gerardus Hendrikus Kamphuis, Stephen A Rappaport, Anke Bongers, S. H. N. Swinkels, Raj C. Shah, David A. Bennett, Carl H. Sadowsky

Publikováno v: Alzheimer's Research & Therapy, 5(6). BioMed Central
Alzheimer's Research & Therapy
Shah, R C, Kamphuis, P J, Leurgans, S, Swinkels, S H, Sadowsky, C H, Bongers, A, Rappaport, S A, Quinn, J F, Wieggers, R L, Scheltens, P & Bennett, D A 2013, ' The S-Connect study: results from a randomized, controlled trial of Souvenaid in mild-to-moderate Alzheimer's disease ', Alzheimer's Research & Therapy, vol. 5, no. 6, pp. 59 . https://doi.org/10.1186/alzrt224

Introduction Souvenaid® containing Fortasyn® Connect is a medical food designed to support synapse synthesis in persons with Alzheimer’s disease (AD). Fortasyn Connect includes precursors (uridine monophosphate; choline; phospholipids; eicosapent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda2627c30c2fab31a60f21ffdde64fe
https://research.vumc.nl/en/publications/e0d64a0f-6434-4742-9000-42f52cd0bf5e

P4‐349: Safety, compliance and the effects on memory of 48‐week Souvenaid use in mild Alzheimer's disease: Results from the Souvenir II and open‐label extension study

Autor: John P. Harrison, Elio Scarpini, Christine A. F. von Arnim, Jos W. R. Twisk, Patrick Joseph Gerardus Hendrikus Kamphuis, S. H. N. Swinkels, Bruno Vellas, R.L. Wieggers, Anke Bongers, Rafael Blesa, Richard J. Wurtman, Philip Scheltens

Publikováno v: Alzheimer's & Dementia. 8

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https://doi.org/10.1016/j.jalz.2013.08.130

Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial

Autor: Rafael Blesa, Philip Scheltens, Patrick Joseph Gerardus Hendrikus Kamphuis, Anke Bongers, H. de Waal, John Harrison, Elio Scarpini, Bruno Vellas, S. H. N. Swinkels, R.L. Wieggers, Jos W. R. Twisk, Richard J. Wurtman, C. A. F. von Arnim, Cornelis J. Stam

Publikováno v: Journal of Alzheimer's Disease, 31(1), 225-236. IOS Press
JOURNAL OF ALZHEIMERS DISEASE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Scheltens, P, Twisk, J W, Blesa, R, Scarpini, E, von Arnim, C A F, Bongers, A, Harrison, J, Swinkels, S H N, Stam, C J, de Waal, H, Wurtman, R J, Wieggers, R L, Vellas, B & Kamphuis, P J G H 2012, ' Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial ', Journal of Alzheimer's Disease, vol. 31, no. 1, pp. 225-236 . https://doi.org/10.3233/JAD-2012-121189

Souvenaid aims to improve synapse formation and function. An earlier study in patients with Alzheimer's disease (AD) showed that Souvenaid increased memory performance after 12 weeks in drug-naïve patients with mild AD. The Souvenir II study was a 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9eb5054f6b0f419eb4d250f3945c8c
https://research.vumc.nl/en/publications/de121d26-a1cc-4ae7-ad17-37b71bcfba89