Maintaining and breaking symmetry in homomeric coiled-coil assemblies

Autor: R.L. Brady, Adrian J. Mulholland, Eric J. M. Lang, Christopher W. Wood, Guto G. Rhys, Derek N. Woolfson, Andrew R. Thomson

Publikováno v: Rhys, G G, Wood, C W, Lang, E J M, Mulholland, A J, Brady, R L, Thomson, A R & Woolfson, D N 2018, ' Maintaining and breaking symmetry in homomeric coiled-coil assemblies ', Nature Communications, vol. 9, no. 1, 4132 . https://doi.org/10.1038/s41467-018-06391-y
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Rhys, G, Wood, C W, Lang, E J M, Mulholland, A, Brady, R L, Thomson, A & Woolfson, D 2018, ' Maintaining and breaking symmetry in homomeric coiled-coil assemblies ', Nature Communications, vol. 9, no. 1, 4132 . https://doi.org/10.1038/s41467-018-06391-y

In coiled-coil (CC) protein structures α-helices wrap around one another to form rope-like assemblies. Most natural and designed CCs have two–four helices and cyclic (Cn) or dihedral (Dn) symmetry. Increasingly, CCs with five or more helices are b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726cf574871562a37408aaf93349ff04
https://doi.org/10.1038/s41467-018-06391-y

The crystal structure of PEBP-2, a homologue of the PEBP/RKIP family

Autor: R.L. Brady, Mark J. Banfield, P. C. Simister

Publikováno v: Acta Crystallographica Section D Biological Crystallography. 58:1077-1080

Proteins from the PEBP (phosphatidylethanolamine-binding protein) family have been identified in a wide variety of species and are thought to regulate a range of intracellular signalling cascades. The rat homologue (known as RKIP; Raf-1 kinase inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f51fad9e2cef6e3d57acfbe9c361c2b
https://doi.org/10.1107/s090744490200522x

CD4 and the immunoglobulin superfamily

Autor: R.L. Brady, S. J. Davis, G. Lange, A N Barclay

Publikováno v: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 342:7-12

The CD4 membrane glycoprotein was one of the first cell surface antigens to be identified using monoclonal antibodies. It was shown to have a central role in the control of the recognition of foreign proteins by T lymphocytes and later as a receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f28aa4dfed93a5f9f1540050aa613bf
https://doi.org/10.1098/rstb.1993.0129

Homology modeling of antibody combining sites

Autor: Rod E. Hubbard, R.L. Brady, D.J. Edwards

Publikováno v: ImmunoMethods. 1:71-79

The antigen combining site of antibody molecules consists of six separate loops supported by a conserved β-sheet framework. The specificity of the antibody is conferred by the structure of these loops, which in turn is related to their length and se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::944cfbabf417c1d6f94a54d12bfa649c
https://doi.org/10.1016/s1058-6687(05)80030-0

A preliminary account of the properties of recombinant human Glyoxylate reductase (GRHPR), LDHA and LDHB with glyoxylate, and their potential roles in its metabolism

Autor: G. Rumsby, Michael P.S. Booth, K. Mdluli, R.L. Brady

Publikováno v: Biochimica et biophysica acta. 1753(2)

Human lactate dehydrogenase (LDH) is thought to contribute to the oxidation of glyoxylate to oxalate and thus to the pathogenesis of disorders of endogenous oxalate overproduction. Glyoxylate reductase (GRHPR) has a potentially protective role metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595297812f36ba6f0d5dcf3bb7eaf37d
https://pubmed.ncbi.nlm.nih.gov/16198644