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Lack of Association between Common Polymorphisms in Genes of the Renin-Angiotensin System and Mortality after Myocardial Infarction

Autor: Fotios G. Kardaras, Elias Gialafos, Stefanos G. Foussas, Stylianos Tzeis, Michalis N. Zairis, George Andrikopoulos, R.K. Mattu, Christodoulos Stefanadis, Dimitri J. Richter, Pavlos Toutouzas, Edward W. Needham

Publikováno v: Cardiology. 103:185-188

The insertion/deletion (I/D) polymorphism in the ACE gene and the A1166C polymorphism in the AT1R gene have been associated with left ventricular remodelling and prognosis after acute myocardial infarction (AMI). We investigated whether these genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cf896179960c8feb5829310f8b18d0
https://doi.org/10.1159/000084592

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The paradoxical association of common polymorphisms of the renin-angiotensin system genes with risk of myocardial infarction

Autor: Fotios G. Kardaras, Dimitri J. Richter, Pavlos Toutouzas, Stefanos G. Foussas, Evaggelos G. Papasteriadis, Michalis N. Zairis, Christodoulos Stefanadis, Paraskeui G. Vogiatzi, John Gialafos, George Andrikopoulos, R.K. Mattu, Gemig study investigators, Edward W. Needham, Elias Gialafos, Stylianos E. Tzeis

Publikováno v: European Journal of Cardiovascular Prevention & Rehabilitation. 11:477-483

BackgroundThe insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) and the A1166C polymorphism of the angiotensin-II AT1 receptor (AT1R) have been extensively investigated as possible risk factors for myocardial infarction (MI).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::474dcabc2834eda54220e87eea250200
https://doi.org/10.1097/01.hjr.0000152240.05585.da

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Gene for Arrhythmogenic Right Ventricular Cardiomyopathy With Diffuse Nonepidermolytic Palmoplantar Keratoderma and Woolly Hair (Naxos Disease) Maps to 17q21

Autor: Mark I. Otter, Aman S. Coonar, Edward W. Needham, Richard S. Houlston, Nikos Protonotarios, William J. McKenna, R.K. Mattu, Adalena Tsatsopoulou, Victoria Murday, Sandeep Cliff

Publikováno v: Circulation. 97:2049-2058

Background —Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease of unknown etiology that causes arrhythmias, heart failure, and sudden death. Diagnosis can be difficult, and this hampers investigation of its molecular b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a8b00e3854855dbbb968c872f00fec
https://doi.org/10.1161/01.cir.97.20.2049

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A DNA Variant at the Angiotensin-Converting Enzyme Gene Locus Associates With Coronary Artery Disease in the Caerphilly Heart Study

Autor: Adrian J. L. Clark, Edward W. Needham, R.K. Mattu, Evanthia Frangos, Mark J. Caulfield, David J. Galton

Publikováno v: Circulation. 91:270-274

Background We analyzed an insertion/deletion (I/D) polymorphism of the angiotensin I–converting enzyme (ACE) gene in 1226 subjects from the Caerphilly Prospective Heart Disease Study. Amplification of genomic DNA using the polymerase chain reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6579d91d1072a2ba385b363b6edf79b7
https://doi.org/10.1161/01.cir.91.2.270

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Comparison of the effect of enalapril and losartan in conjunction with surgical coronary revascularisation versus revascularisation alone on systemic endothelial function

Autor: R.K. Mattu, Edward W.A. Needham, Jasper Trevelyan, A Morris

Publikováno v: Heart (British Cardiac Society). 91(8)

Objectives: To investigate the effect of enalapril, losartan, and surgical coronary revascularisation on endothelial function, and the role of the angiotensin converting enzyme (ACE) insertion (I)/deletion (D) polymorphism. Design: Randomised, contro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f19ccb7abc06f86e89680b925dc03e1
https://pubmed.ncbi.nlm.nih.gov/16020596

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Sources of diagnostic inaccuracy of conventional versus new diagnostic criteria for myocardial infarction in an unselected UK population with suspected cardiac chest pain, and investigation of independent prognostic variables

Autor: S C H Smith, R.K. Mattu, Edward W.A. Needham, Jasper Trevelyan

To assess the degree and sources of current diagnostic inaccuracy of serial conventional cardiac markers and ECGs compared with the new diagnostic criteria for myocardial infarction, with specific reference to physician specialty and the prognostic v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817eedaf6e9f94495189d07abcabf9ad
https://europepmc.org/articles/PMC1767993/

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Association of the ile405val mutation in cholesteryl ester transfer protein gene with risk of acute myocardial infarction

Autor: Dimitris J. Richter, John Gialafos, R.K. Mattu, George Andrikopoulos, F G Kardaras, Kostas Kappos, Michalis N. Zairis, Ewa Needham, C. Stefanadis, P.K. Toutouzas, Elias Gialafos, K E Paravolidakis, Stefanos G. Foussas, E N Karabinos, Polychronis E. Dilaveris, Evangelos G. Papasteriadis

Publikováno v: Heart. 90:1336-1337

Cholesteryl ester transfer protein (CETP) not only regulates removal of excess cholesterol to the liver but also mediates the transfer of esterified hydrophobic cholesterol to the potentially atherogenic low density lipoprotein (LDL) and intermediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3bda2d26f0e89bc21c8b7a598c096ce
https://doi.org/10.1136/hrt.2003.019067

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DNA variants at the LPL gene locus associate with angiographically defined severity of atherosclerosis and serum lipoprotein levels in a Welsh population

Autor: R. Morgan, R.K. Mattu, Joseph Stocks, A. Rees, E.W.A. Needham, P. C. Elwood, David J. Galton, A. K. Hackshaw

Publikováno v: Arteriosclerosis and thrombosis : a journal of vascular biology. 14(7)

Coronary artery disease (CAD) patients (n = 235), comprising minimal (CAD-, n = 124) and severe (CAD+, n = 111) CAD, were recruited on the basis of their angiographic scores. Male control subjects (n = 123) were selected randomly from the Caerphilly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d92df4ce5d13df3e7295985b35ef20
https://pubmed.ncbi.nlm.nih.gov/7912549

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