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Publikováno v:
Angewandte Chemie International Edition. 41:4249-4252
Publikováno v:
Angewandte Chemie. 114:4423-4426
Autor:
Les Olson, R.J. Wieser, Jennifer L. Katz, Gizelda T. Casella, Irene S. Margitich, Patrick M. Wood, Richard P. Bunge
Publikováno v:
Glia. 30:165-177
Cessation of division is prerequisite for Schwann cell differentiation but regulation of this critical function is poorly understood. Heregulin/forskolin-induced growth of human Schwann cells (HSCs) in vitro was found to be strongly regulated by cell
Publikováno v:
Oncogene. 18:277-281
Growth of non-transformed cells in vitro is regulated by density-dependent mechanisms via cell-cell contacts, leading to arrest in late G1-phase at confluency (contact-inhibition of growth). In the present study it is shown that this results from p16
Publikováno v:
Oncogene. 15:2743-2747
In the present work we studied mechanisms of growth control in contact-inhibited and serum-deprived human diploid fibroblasts. The observation that the effects on [3H]thymidine incorporation and reduction of retinoblastoma gene product-phosphorylatio
Autor:
Franz Oesch, R.J. Wieser
Publikováno v:
Trends in Glycoscience and Glycotechnology. 4:160-167
形質転換を受けていない哺乳動物細胞の増殖の調節は細胞密度によって厳密な支配を受けている。細胞密度が増加すると、増殖は加速度的に抑制され、ついにはコンフルエントな状態で
Publikováno v:
The Journal of Cell Biology
Previous studies have shown that plasma membrane compounds are involved in the contact-dependent inhibition of growth of human diploid fibroblasts. The purification of the active plasma membrane glycoprotein is described in this report. The glycoprot
Autor:
Nicolas Gumpert, Cornelia Dietrich, R.J. Wieser, Franz Oesch, Isabelle Heit, Monika Borchert-Stuhlträger
Publikováno v:
Biochemical and biophysical research communications. 282(2)
PKCdelta plays a fundamental role in cell cycle control. Consistent with its proposed tumour suppressor function, ras transfection of the human keratinocyte cell line HaCaT results in a loss of PKCdelta expression mediated by TGFalpha (Exp. Cell Res.
Autor:
Dagmar Faust, Cornelia Dietrich, Isabelle Heit, R.J. Wieser, Monika Borchert-Stuhlträger, Franz Oesch, Thomas Herget
Publikováno v:
Oncogene. 20(37)
There is evidence that protein kinase C delta (PKCdelta) is a tumor suppressor, although its physiological role has not been elucidated so far. Since important anti-proliferative signals are mediated by cell-cell contacts we studied whether PKCdelta