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pro vyhledávání: '"R.J. Safford"'
Akademický článek
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Akademický článek
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Publikováno v:
Regulatory toxicology and pharmacology : RTP. 60(2)
An essential step in ensuring the toxicological safety of ingredients in consumer products is the evaluation of their skin sensitising potential. Where skin exposure is low, it is possible to conduct a risk assessment using the Dermal Sensitisation T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ed2117cde56df3d17cd25a47033dcb
https://pubmed.ncbi.nlm.nih.gov/21447365
https://pubmed.ncbi.nlm.nih.gov/21447365
Autor:
R.J. Safford
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 51(2)
The Threshold of Toxicological Concern (TTC) is a useful concept that is becoming of increasing interest as an addition to the arsenal of tools used for characterising the toxicological risk of human exposure to chemicals. Traditionally used for low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea828bca83034ee5d62eb1a428a365ec
https://pubmed.ncbi.nlm.nih.gov/18406502
https://pubmed.ncbi.nlm.nih.gov/18406502
Publikováno v:
The British journal of dermatology. 123(5)
In this study, the nature of non-immune immediate contact reactions (NIICR) produced by cinnamic aldehyde, benzoic acid and sorbic acid were investigated, with particular interest in the 'quenching' ability of eugenol. Three groups of human subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c817c57ef5610aefaefe70ff1350fefa
https://pubmed.ncbi.nlm.nih.gov/2248889
https://pubmed.ncbi.nlm.nih.gov/2248889
Akademický článek
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Autor:
B.F.J. Goodwin, R.J. Safford
Publikováno v:
International Archives of Allergy and Immunology. 77:331-336
Tartrazine is occasionally associated with some clinical changes which have been attributed to allergy. In tests on laboratory animals with tartrazine and its metabolites by methods which should have detected potential to induce antibody formation, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375eb52d78eb2b43e6b32ff75344c3c5
https://doi.org/10.1159/000233840
https://doi.org/10.1159/000233840
Publikováno v:
Food and Cosmetics Toxicology. 17:129-135
Potassium dipersulphate, ammonium dipersulphate and potassium monopersulphate release histamine from rat peritoneal mast cells in vitro, and from guinea-pig skin in vitro and in vivo. Potassium dipersulphate releases histamine from rat peritoneal mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae127dff84ca2ac37e2266acf8ab060
https://doi.org/10.1016/0015-6264(79)90210-4
https://doi.org/10.1016/0015-6264(79)90210-4
Publikováno v:
Food and Chemical Toxicology. 24:521-523
A system is described in which cells in vitro are perifused continuously with appropriate medium while, simultaneously, any change in cell morphology is recorded, together with data on released products (enzymes and mediators) in the perifusate follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b2944fcb67e389e96c71627b77fe6ed
https://doi.org/10.1016/0278-6915(86)90106-7
https://doi.org/10.1016/0278-6915(86)90106-7
Autor:
R.J. Safford, B.F.J. Goodwin
Publikováno v:
International journal of immunopharmacology. 6(3)
The release of histamine from purified rat peritoneal mast cells induced by specific antigen (egg albumin), compound 48/80 and calcium ionophore A23187 was modified by tartrazine. Histamine release induced by 48/80 and antigen was inhibited by the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4b14afbad38b12315319189887c5aa
https://pubmed.ncbi.nlm.nih.gov/6204951
https://pubmed.ncbi.nlm.nih.gov/6204951