Zobrazeno 1 - 10
of 40
pro vyhledávání: '"R.J. Potts"'
Publikováno v:
Toxicology. 184:157-178
This study demonstrates that in vitro exposure of adult rat alveolar epithelial cells to CdCl(2) decreases DNA binding activity of specificity protein 1 (Sp1), a zinc-finger transcription factor known to play a key role in eukaryotic gene expression,
Publikováno v:
Toxicology. 160:65-70
This review article discusses the major cellular and molecular responses characterizing pulmonary adaptation to cadmium (Cd) that may ultimately contribute to Cd carcinogenesis. Hallmarks of Cd adaptation include hyperplasia and hypertrophy of type I
Publikováno v:
Toxicology. 161:25-38
This study evaluated the effects of cadmium (Cd) adaptation in cultured alveolar epithelial cells on oxidant-induced DNA damage and its subsequent repair. Using the comet assay, we determined that lower levels of DNA damage occurred in Cd-adapted cel
Publikováno v:
Cell Biology and Toxicology. 16:347-362
Exposure of rat alveolar epithelial cells to 10 μmol/L CdCl2 causes time-dependent increases in steady-state mRNA levels of the γ-glutamylcysteine synthetase catalytic (heavy) subunit (γ-GCS) and of glutathione S-transferase isoforms (GST-α and G
Publikováno v:
Human Reproduction. 14:2513-2516
The human epididymis provides an optimal environment for the storage and maturation of spermatozoa. However, the ability of the epididymis to protect spermatozoa from oxidative attack whilst stored at this site, through the local actions of antioxida
Publikováno v:
International Journal of Andrology. 22:282-288
Extra-epididymal spermatozoa account for approximately a third of all spermatozoa found in the normal human ejaculate. Whilst remaining outside of the testes at core body temperature, the functional competence of spermatozoa, including cell motility
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 423:103-111
Cigarette smoke is a rich source of mutagens and carcinogens; thus, we have investigated the effects of male smoking on the DNA of human sperm. This was performed using the sperm chromatin structure assay (SCSA), which measures the sensitivity of spe
Publikováno v:
Mutation research. 447(2)
Exposure of spermatozoa to reactive oxygen species (ROS) has been associated with cellular injury, that includes DNA damage and lipid peroxidation. In addition, sperm preparation techniques such as centrifugation, commonly used prior to in vitro fert
Publikováno v:
Toxicology. 147(3)
Apoptosis involves a series of genetically programmed events associated with endonucleolytic cleavage of DNA. This process is triggered by a variety of agents, including oxidants such as hydrogen peroxide (H(2)O(2)) and it plays a key role in elimina
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