Effects of GnRH immunization in sexually mature pony stallions

Autor: F J U M van der Meer, Katja J. Teerds, J.A. Turkstra, J. Knaap, Ben Colenbrander, Peter J. M. Rottier, R.H. Meloen

Publikováno v: Animal Reproduction Science, 86(3-4), 247-259
Animal Reproduction Science 86 (2005) 3-4

Immunization against gonadotrophin releasing hormone (GnRH) was studied as an alternative for the commonly used surgical castration in stallions. Two GnRH vaccines comprising non-mineral oil adjuvants were evaluated for their potential to induce high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d687824b1f6968d066e967663a3239
https://doi.org/10.1016/j.anireprosci.2004.07.010

New transport peptides broaden the horizon of applications for peptidic pharmaceuticals

Autor: J.P.M. Langedijk, R.H. Meloen, R Autar, D Schut, T. Olijhoek

Publikováno v: Molecular Diversity. 8:101-111

Protein transduction domains (PTDs) have proven to be an invaluable tool to transduce a wide variety of cargo's including peptides across the plasma membrane and into intact tissue. The PTDs are able to deliver biologically active molecules both in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cdc9e5291b655f380856a1dc433bcf4
https://doi.org/10.1023/b:modi.0000025653.26130.ce

The nature of the bond between peptide and carrier molecule determines the immunogenicity of the construct

Autor: R.H. Meloen, Ronald S. Boshuizen, W.M.M. Schaaper, N. J. C. M. Beekman, Jan P. M. Langeveld

Publikováno v: The Journal of Peptide Research. 58:237-245

The influence of the nature of the bond between a peptide and a (lipidic) carrier molecule on the immunogenicity of that construct was investigated. As types of bonds a thioester-, a disulfide-, an amide- and a thioether bond were investigated. As ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f40c48caeff5b3ebf739500bc61e9bfc
https://doi.org/10.1034/j.1399-3011.2001.00905.x

Active Immunization against Gonadotrophin-releasing Hormone in Chinese Male Pigs

Autor: D.Z Guo, H.B. Oonk, J.A. Turkstra, F.Q. Chen, X.Y. Zeng, D. F. M. van de Wiel, R.H. Meloen, X. Zhang, W.M.M. Schaaper, X.Y. Liu

Publikováno v: Reproduction in Domestic Animals. 36:101-105

We have investigated, under the normal conditions of local Chinese pig farming, castration of young male pigs by vaccination with a newly developed vaccine against gonadotrophin releasing hormone (GnRH). Because of the very early onset of puberty, lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ab20773ac1a5c345fca70ad89c3ea8
https://doi.org/10.1046/j.1439-0531.2001.00256.x

In Vitro Inhibition of the Biological Activity of Follicle-Stimulating Hormone by Anti-Peptide Antisera Representing the Human Follicle-Stimulating Hormone β Subunit Sequence 33–531

Autor: L. van Leeuwen, R.H. Meloen, W.M.M. Schaaper, H.B. Oonk, J. W. Slootstra, Wouter Cornelis Puijk, W. E. Westhoff

Publikováno v: Biology of Reproduction, 460-468. Society for the Study of Reproduction
ISSUE=56;STARTPAGE=460;ENDPAGE=468;ISSN=0006-3363;TITLE=Biology of Reproduction

There are few male contraceptive methods, and research is required to broaden the scope of available male antifertility methods. Two approaches toward hormonal contraception are currently being investigated. The first relies on elimination of testost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b152519ca14282ac2c7bb5b3597879d6
https://doi.org/10.1095/biolreprod56.2.460