Zobrazeno 1 - 10
of 47
pro vyhledávání: '"R.G.A. Jones"'
Autor:
Angela Martino, R.G.A. Jones
Publikováno v:
Critical Reviews in Biotechnology. :1-15
Therapeutic antibodies provide important tools in the "medicine chest" of today's clinician for the treatment of a range of disorders. Typically monoclonal or polyclonal antibodies are administered in large doses, either directly or indirectly into t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643e15214b3abef47e522bcd16b1e67d
https://doi.org/10.3109/07388551.2014.992388
https://doi.org/10.3109/07388551.2014.992388
Autor:
R.G.A. Jones, James D. Marks
Publikováno v:
Journal of Medical Microbiology. 62:828-835
Clostridium botulinum type A toxin is the most prevalent cause of naturally occurring outbreaks of human botulism in the world. The active dichain neurotoxin molecule is composed of a heavy chain (H-chain) of ~100 kDa with the carboxy-terminal end co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096bc408e536e104e1aa383b7f776e97
https://doi.org/10.1099/jmm.0.053124-0
https://doi.org/10.1099/jmm.0.053124-0
Publikováno v:
Analytical Biochemistry. 425:28-35
Conventional capture (“Sandwich”) ELISAs equally detect denatured inactive and native active botulinum type A toxin. Light chain endoprotease activity assays also fail to distinguish between various inactive molecules including partially denature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7c6d9850ddf4138a13c92340202b7d
https://doi.org/10.1016/j.ab.2012.02.038
https://doi.org/10.1016/j.ab.2012.02.038
Autor:
Colin Longstaff, Yvonne Liu, Susan J. Thorpe, Chris Halls, Dorothea Sesardic, R.G.A. Jones, Paul Matejtschuk
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 54:74-80
Botulinum type A toxin (BoNT/A) is defined by its specific endopeptidase cleavage of SNAP25 between Gln(197) and Arg(198) under reducing conditions. The neurotoxin is widely used for therapeutic or cosmetic purposes, but should not contain other toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0eb1a6a2a8cb3c26a3cf89f3faa453
https://doi.org/10.1016/j.jpba.2010.08.013
https://doi.org/10.1016/j.jpba.2010.08.013
Publikováno v:
Journal of Immunological Methods. 329:92-101
Botulinum neurotoxins contain proteases that cleave specific intra-neural proteins essential for neurotransmitter release. Toxin types A, E and C1 intra-cellularly cleave SNAP25 resulting in a flaccid paralysis. As a consequence, various different en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c35b5c3407d1a0bd30a14ebd2d8bbc
https://doi.org/10.1016/j.jim.2007.09.014
https://doi.org/10.1016/j.jim.2007.09.014
Publikováno v:
Biologicals. 34:223-226
Clostridium botulinum produces the most potent known toxins, with seven distinct serotypes currently defined (A-G). These toxins can cause a life threatening systemic toxicity whether through natural causes such as food poisoning, infant botulism, wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c914ad11de0f60eec6cc2c7bec2cc6
https://doi.org/10.1016/j.biologicals.2005.11.009
https://doi.org/10.1016/j.biologicals.2005.11.009
Autor:
J Landon, R.G.A. Jones
Publikováno v:
Journal of Immunological Methods. 275:239-250
The digestion of ovine antiserum under acidic conditions (pH 3.5) by pepsin is highly effective at reducing all unwanted serum components to low molecular weight (< or =13 kDa) fragments while leaving the approximately 100-kDa F(ab')(2) intact. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c60870600ef85dd9c5d4529218554b4
https://doi.org/10.1016/s0022-1759(03)00005-x
https://doi.org/10.1016/s0022-1759(03)00005-x
Publikováno v:
Food and Bioproducts Processing. 80:88-97
Asimple process for the manufacture of polyclonal F(ab′)2 fragments that might be adopted for the facile preparation of antivenoms is described. The production of polyclonal F(ab′)2 fragments from serum commonly involves the initial purification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e84d3e47c3061276c3e20c1adca37d9
https://doi.org/10.1205/09603080252938726
https://doi.org/10.1205/09603080252938726
Autor:
J Landon, R.G.A. Jones
Publikováno v:
Journal of Immunological Methods. 263:57-74
Enzyme-cleaved antibodies are used widely for the treatment of envenoming. Such products should comprise only 'highly pure' immunoglobulin fragments since Fc or other contaminating protein fragments or their aggregates may lead to side effects. The d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d584711da84c49920d16a7e647daaed
https://doi.org/10.1016/s0022-1759(02)00031-5
https://doi.org/10.1016/s0022-1759(02)00031-5
Publikováno v:
Europe PubMed Central
The frequency of mass bee attacks has dramatically increased in the Americas following the introduction and spread of the aggressive Africanized 'killer' bee (Apis mellifera scutellata). As yet no specific therapy is available, which led us to develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb11560d375dfd8f24ac45c7e8bdeea
https://doi.org/10.4269/ajtmh.1999.61.361
https://doi.org/10.4269/ajtmh.1999.61.361