Zobrazeno 1 - 10
of 345
pro vyhledávání: '"R.E. GAY"'
Publikováno v:
Zeitschrift für Rheumatologie. 68:37-43
Zusammenfassung: Die systemische Sklerose (SSc) ist eine Multisystemfibrose mit weltweitem Vorkommen und hoher Morbidität und Mortalität. Charakteristika der Erkrankung sind ausgedehnte Vaskulopathie, Entzündung, Autoimmunität und Fibrose. Therap
Publikováno v:
Biomedicine & Pharmacotherapy. 53:218-222
Summary A bidirectional communication network exists between the neuroendocrine and immune systems, and a dysfunctional communication may contribute to the development of autoimmune diseases in various species, including humans. Experimental, epidemi
Autor:
M. Frank-Bertoncelj, G. Russo, A. Bratus, C. Kolling, A. Filer, B.A. Michel, R.E. Gay, C.D. Buckley, S. Gay, C. Ospelt
Publikováno v:
Annals of the Rheumatic Diseases. 75:55.2-55
Background A number of susceptibility loci for rheumatoid arthritis (RA) map to noncoding genomic regions. Long noncoding RNA (lncRNA) represent the largest part of noncoding transcriptome and are key regulators of gene expression. We have recently s
Autor:
K. Klein, R.E. Gay, C. Kolling, L.-L. Lin, N. Bostanci, G. Belibasakis, B.A. Michel, S. Gay, C. Ospelt
Publikováno v:
Annals of the Rheumatic Diseases. 75:672.2-672
Background In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to a tolerant state of the cell which protects inflamed tissues from damage. We have recently shown that rheumatoid arthritis (RA) synovial fibroblasts (SF) lack thes
Autor:
K. Umekita, S. Miyauchi, M. Matsuda, K. Kubo, M. Komura, H. Nomura, A. Kawano, K. Umeki, I. Takajo, Y. Nagatomo, M. Frank-Bertoncelj, R.E. Gay, S. Gay, A. Okayama
Publikováno v:
Annals of the Rheumatic Diseases. 75:906.1-906
Background Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in the rheumatoid arthritis (RA) joints resulting in increased expression of proinflammatory cytokines and chemokines. In
Publikováno v:
Annals of the Rheumatic Diseases. 75:106.2-107
Background Activated macrophages and synovial fibroblasts (SF) are found in the inflamed and hyperplastic synovial rheumatoid arthritis (RA) tissues. Our group has already reported a persistent global hypomethylation in RA tissues and RA synovial fib
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Publikováno v:
Lung Cancer. 6:16-27
Malignant mesotheliomas often constitute a difficult diagnostic problem. A possible marker for a mesenchymal origin of the tumor is the type of collagen produced. A study was therefore made of the immunocytochemical reactivity of collagen type I, as
Autor:
N. Gaur, E. Karouzakis, A. Jungel, M. Frank-Bertoncelj, E. Bagdonas, C. Kolling, B.A. Michel, R.E. Gay, S. Gay, M. Neidhart
Publikováno v:
Annals of the Rheumatic Diseases. 74:741.3-742
Background Rheumatoid arthritis synovial fibroblasts (RASF) show global DNA hypomethylation mirrored in their intrinsically activated and aggressive phenotype. Methyl donors, such as L-methionine (LM) and betaine (BT), as diet supplements feed into t
Autor:
M. Frank Bertoncelj, M. Trenkmann, M. Armaka, G. Russo, A. Bratus, C. Kolling, B.A. Michel, R.E. Gay, C.D. Buckley, G. Kollias, S. Gay, C. Ospelt
Publikováno v:
Annals of the Rheumatic Diseases. 74:95.1-95
Background Molecular mechanisms underlying differential topographic susceptibility of joints to rheumatoid arthritis (RA) are unknown. Positional expression of Hox genes along the body axis regulates limb development. Adult skin fibroblasts retain th