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pro vyhledávání: '"R.E. Counsell"'
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Autor:
Jamey P. Weichert, Susan J. Fisher, Richard L. Wahl, M. A. Rampy, R. W. S. Skinner, M. D. Gross, Anatoly Pinchuk, R.E. Counsell
Publikováno v:
Journal of Medicinal Chemistry. 38:3156-3162
Radioiodinated phospholipid ethers have shown the remarkable ability to selectively accumulate in a variety of animal tumors as well as in human tumor xenografts. It has been suggested that this tumor avidity may arise as a consequence of metabolic d
Publikováno v:
Nuclear Medicine and Biology. 22:95-103
Using organozinc cross-coupling reactions, two radiolabeled analogs of 15-(p-iodophenyl) pentadecanoic acid (IPPA) have been designed and synthesized as potential scintigraphic imaging agents for the heart. Both 15-(4-iodophenyl)-tridecylglycidic aci
Autor:
T.S. Chou, R. W. S. Skinner, Anatoly Pinchuk, R.E. Counsell, Susan J. Fisher, Richard L. Wahl, M. A. Rampy, Milton D. Gross
Publikováno v:
Nuclear medicine and biology. 22(4)
Previous work has shown that radioiodinated phospholipid ether analogs with the iodine-125 substituted on the meta position of the aromatic ring readily localized in a variety of animal tumors. In an effort to ascertain the importance of such meta su
Publikováno v:
Steroids. 44:85-93
A series of radioiodinated pregnenolone esters was prepared in an effort to find an agent that would be rapidly and selectively taken up by adrenal cortical tissue. Achievement of such a goal would provide the basis for the development of an adrenal
Publikováno v:
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 16:603-607
A series of radioiodinated benzoate and carbamate esters of cholesterol and pregnenolone wherein the acyl moiety served as the carrier for radioiodine was synthesized and evaluated as potential imaging agents for the adrenal cortex. 2,6-Dimethyl-3-io
Autor:
G.W. Adelstein, R.E. Counsell
Publikováno v:
Journal of Pharmaceutical Sciences. 55:947-950
Hypoiodite oxidation of 3 α -bromo and 3 α -chloro-2 β -hydroxy-5 α -androstan-17-one gave the expected 2 β ,19-oxide along with lesser amounts of 16-iodinated, 19-hydroxylated, and 19-acetoxylated products. The product composition as well as th
Autor:
R.E. Counsell
Publikováno v:
Tetrahedron. 15:202-211
Various 3,17-oxygenated isomeric estrane derivatives have been synthesized as possible metabolites of 19-norsteroids. Methods employed to establish configurations are described and biological data on some of the more pertinent compounds is presented.
Autor:
R.E. Counsell, Robert E. Willette
Publikováno v:
Journal of Pharmaceutical Sciences. 55:1012-1015
1,1-Dichloro-2-( o -chlorophenyl)-2-( p -chlorophenyl- 14 C)ethane( o , p ′-DDD- 14 C), 1,1-sichlora-2-( m -chlorophenyl)-2-( p -chlorophenyl- 14 C)ethne(m, P′-DDD- 14 C) and 1,1-dichloro-2,2-bis-( p -chlorophenyl- 14 C)ethane( p , p′-DDD- 14 C
Publikováno v:
Journal of Pharmaceutical Sciences. 57:1657-1661
The preparation of 1,1-dichloro-2-(p-chlorophenyl)-2-(o-iodophenyl-125I)ethane and 1,1-dichloro-2-(p-chlorophenyl)-2-(m-iodophenyl-125I)ethane is reported. These compounds were prepared by chlorination of the appropriate iodoacetophenone, reduction t