Výsledky vyhledávání - "R.C. Sheppard"

Rapid synthesis of oligodeoxyribonucleotides IV. Improved solid phase synthesis of oligodeoxy-ribonucleotides through phosphotriester intermediates

Autor: Clive R. Newton, T.C. Atkinson, G.R. Heathcliffe, A.R. Greene, Michael J. Gait, R.C. Sheppard, M. Singh, A.F. Markham, Michael Derek Edge

Publikováno v: Nucleic Acids Research. 8:1081-1096

A phosphotriester solid phase method on a polyamide support has been used to prepare oligodeoxyribonucleotides up to 12 units long. Compared to solid phase phosphodiester synthesis the new methodology is quicker, more flexible and gives 10-60-fold be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfcf5163ff851bb0b7824ebc05553c1
https://doi.org/10.1093/nar/8.5.1081

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Rapid chemical synthesis and circular dichroism properties of some 2′-5′-linked oligoriboadenylates

Autor: R.A. Porter, R.C. Sheppard, I.M. Kerr, M.J. Gait, A.F. Markham

Publikováno v: Nucleic Acids Research. 6:2569-2582

Specific synthesis of some oligoadenylates including A2'p5'A2'p5'Ap(2'), the 2'-phosphorylated oligoribonucleotide core of the recently discovered protein synthesis inhibitor pppA2'p5'A2'p5'A is described using a novel solid-phase method. The CD spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e8330976552840efbdac8f1b3864ee1
https://doi.org/10.1093/nar/6.7.2569

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Rapid synthesis of oligodeoxyribonucleotides II1. Machine-aided solid-phase syntheses of two nonanucleotides and an octanucleotide

Autor: R.C. Sheppard, M.J. Gait

Publikováno v: Nucleic Acids Research. 4:4391-4410

Preparation of the two nonanucleotides, d(pG-G-A-G-G-A-G-A-A) and d(pT-T-C-T-G-T-T-G-A), and the octanucleotide, d(pT-G-G-C-C-C-A-T) is described by a rapid solid-phase method on a polyamide support. The syntheses were carried out using a modified so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6ed27b559d66acb6a9c5093f073a80a
https://doi.org/10.1093/nar/4.12.4391

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Solid-phase oligonucleotide synthesis: a renaissance

Autor: R.C. Sheppard, M.J. Gait

Publikováno v: Nucleic Acids Research. 5:s79-s84

A practical solid-phase method is described using a polar polyamide support for the synthesis of medium-length oligodeoxyribonucleotides. Chain assembly can be facilitated with the aid of a modified solid-phase peptide synthesiser. Hplc on both analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160ba7d191d51b848dd13a95d33216f6
https://doi.org/10.1093/nar/1.suppl_1.s79

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Cyclopropane amino acids from Aesculus and Blighia

Autor: Leslie Fowden, D.S. Millington, A. Smith, R.C. Sheppard

Publikováno v: Phytochemistry. 8:437-443

Three compounds containing cyclopropane ring systems have been newly characterized from Aesculus parviflora and Blighia sapida . Exo -3,4-methanoproline was isolated together with its probable biogenetic precursor, cis -α-(carboxycyclopropyl)glycine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43da8eca190fdc506e748da43a20613f
https://doi.org/10.1016/s0031-9422(00)85446-1

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Acetylenic amino acids from euphoria longan

Autor: May-Lin Sung, D.S. Millington, Leslie Fowden, R.C. Sheppard

Publikováno v: Phytochemistry. 8:1227-1233

Three amino acids containing an acetylenic bond have been newly characterized from seed of Euphoria longan. Structures were assigned, largely on the basis of hydrogenation, NMR and mass spectrometric studies, as follows: 2-amino-4-methylhex-5-ynoic a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d58b8160c57e57a23df763a7d496860e
https://doi.org/10.1016/s0031-9422(00)85562-4

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Newly characterized amino acids from Blighia unijugata

Autor: Leslie Fowden, R.C. Sheppard, F.A. Mellon, C.M. MacGibbon

Publikováno v: Phytochemistry. 11:1105-1110

Two amino acids have been isolated from seed of Blighia unijugata. The compounds were characterized as trans-α-(2-carboxymethylcyclopropyl)glycine and 2-amino-5-methyl-6-hydroxyhex-4-enoic acid following analysis of their hydrogenation products and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d732e47b35c5cfb30745d6c9bbcefdb3
https://doi.org/10.1016/s0031-9422(00)88461-7

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Rapid synthesis of oligodeoxyribonucleotides. III. Effect of added carboxylate ion on the efficiency of internucleotide bond formation. Solid-phase synthesis of the dodecanucleotide, d(pT-A-A-C-T-G-C-T-C-A-C-T)

Autor: R.C. Sheppard, Michael J. Gait

Publikováno v: Nucleic acids research. 6(4)

In solid-phase oligodeoxyribonucleotide synthesis the addition of benzoic acid to internucleotide phosphodiester bond-forming reactions lowers coupling yields by far greater amount than anticipated on a simple nucleotide-carboxylate molar ratio. High

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4601aea7aa33259f34b465421256102c
https://pubmed.ncbi.nlm.nih.gov/450696

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