Zobrazeno 1 - 10
of 127
pro vyhledávání: '"R.C. CANTRILL"'
Publikováno v:
Cancer Letters. 100:17-21
Polyunsaturated fatty acids are selectively cytotoxic in culture. Incorporation of these fatty acids leads to profound changes in membrane fatty acid composition which in turn may alter the activity of transmembrane receptor/effector systems. In U937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7924b2ae4ae190cb2e2afdf0660e4c6
https://doi.org/10.1016/0304-3835(95)04062-5
https://doi.org/10.1016/0304-3835(95)04062-5
Publikováno v:
Molecular and Cellular Biochemistry. 139:71-81
N-6 fatty acid metabolism was compared in NIH-3T3 cells and DT cells, which differ only in the presence of the v-Ki-ras oncogene. Non-dividing cells were incubated with [1-14C]-labelled fatty acids (18:2n-6, 18:3n-6, 20:3n-6 and 20:4n-6) at different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e54f9cce1935e9e009975aee210a939
https://doi.org/10.1007/bf00944205
https://doi.org/10.1007/bf00944205
Publikováno v:
The Journal of Nutritional Biochemistry. 4:515-522
Low molecular-weight fatty acid binding protein (L-FABP) was purified from rat liver by a combination of gel filtration and affinity chromatography. The purified protein had a molecular weight of 14,000 Daltons as determined by sodium dodecyl sulfate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a5c2930f87724c7bb9daef4756a0769
https://doi.org/10.1016/0955-2863(93)90087-d
https://doi.org/10.1016/0955-2863(93)90087-d
Publikováno v:
Cancer Letters. 72:99-102
Polyunsaturated fatty acids are cytotoxic to ZR-75-1 human breast tumor cells in culture. This effect may be potentiated by the simultaneous addition of iron. When cytotoxicity was measured in the presence of different concentrations of both gamma-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5c84f50b57909ea754fb0c01246ef2
https://doi.org/10.1016/0304-3835(93)90017-4
https://doi.org/10.1016/0304-3835(93)90017-4
Publikováno v:
Lipids. 28:163-166
The incorporation and metabolism of alpha-linolenic acid (18:3n-3) and its delta 6 desaturase product, stearidonic acid (18:4n-3), were compared by NIH-3T3 cells. In the presence of fetal calf serum, cells accumulated exogenously added 18:3n-3 and 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107de8a86f86f2859561c275c74ebcfe
https://doi.org/10.1007/bf02536634
https://doi.org/10.1007/bf02536634
Autor:
D.E. Mills, David F. Horrobin, L. Campbell, A. C. DeMarco, Y. S. Huang, R.C. Cantrill, X. Lin
Publikováno v:
Biochemical medicine and metabolic biology. 51(1)
The present study examined the in vitro and in vivo metabolism of 18:2n-6 and 18:3n 6 by kidney and liver in the male adult spontaneously hypertensive (SHR) and normotensive (WKY) rats. In liver and kidney slices incubated for 1 h with either [1-14C]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cad39b06937d069756117a2bcd6959
https://pubmed.ncbi.nlm.nih.gov/7910749
https://pubmed.ncbi.nlm.nih.gov/7910749
Publikováno v:
Lipids. 28(4)
This study was undertaken to investigate the total plasma fatty acid composition and the relationship between plasma triacylglycerol (TG) levels and liver delta 9 desaturase activity in mice fed n-3 and/or n-6 fatty acid or hydrogenated coconut oil (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b353e1de0ae14912a4891b2a25e9f6bd
https://pubmed.ncbi.nlm.nih.gov/8487620
https://pubmed.ncbi.nlm.nih.gov/8487620
Publikováno v:
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury ISBN: 9781461365624
Cancer cell lines in culture are susceptible to certain polyunsaturated fatty acids (PUFA). Cells expressing a transfected Ki-ras oncogene are also more sensitive to the actions of PUFA than the non- transfected parent line. One possible mechanism is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87774d0c2779e642f93b96247db09b1
https://doi.org/10.1007/978-1-4615-3520-1_109
https://doi.org/10.1007/978-1-4615-3520-1_109
Publikováno v:
Molecular and cellular biochemistry. 118(2)
The present study examines the time dependent effects of n-6 and n-3 polyunsaturated fatty acids on liver microsomal lipid metabolism in FVB mice fed a diet supplemented with a mixture of free fatty acids (mainly 18:3n-6 and 20:5n-3) at 25 mg/g diet.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c6e1cbd5d84cbfb80b5f72b55af5ff
https://pubmed.ncbi.nlm.nih.gov/1293510
https://pubmed.ncbi.nlm.nih.gov/1293510