Zobrazeno 1 - 10
of 81
pro vyhledávání: '"R.A.D. Bunning"'
Publikováno v:
Journal of Bone and Mineral Research. 7:1363-1371
Transforming growth β (TGF-β) has been proposed to have a role in bone remodeling by affecting the differentiation and activity of osteoblasts and osteoclasts and by inhibiting the production of proteinases, such as plasminogen activators (PAs). St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac3f8cb0a6d076c4e23f00294d084cc
https://doi.org/10.1002/jbmr.5650071203
https://doi.org/10.1002/jbmr.5650071203
Publikováno v:
Biochemical Journal. 345:495-501
The effect of mannosamine, an inhibitor of glycosylphosphatidylinositol (GPI) anchor formation, on chondrocyte-mediated cartilage proteoglycan breakdown was investigated using cartilage explant cultures. Mannosamine inhibited interleukin 1α-, tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ac295083c9524e40ed370e721cf4c5c
https://doi.org/10.1042/bj3450495
https://doi.org/10.1042/bj3450495
Autor:
J. Kerrigan, James C. Powers, R. Feltell, H. Bryson, R.A.D. Bunning, David J. Buttle, Chih-Min Kam
Publikováno v:
Archives of Biochemistry and Biophysics. 355:15-25
The role played by serine proteinases with trypsin-like specificity in chondrocyte-mediated cartilage proteoglycan breakdown was investigated by use of a selective proteinase inactivator, 7-amino-4-chloro-3-(-3-isothiureidopropoxy)isocoumarin, in exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03adfd7909b7cdade8109ee3c25275b4
https://doi.org/10.1006/abbi.1998.0696
https://doi.org/10.1006/abbi.1998.0696
Publikováno v:
Cytokine. 2:106-111
Human articular chondrocytes, when stimulated with interleukin 1 beta (IL 1 beta), tumor necrosis factor-alpha (TNF-alpha), or with the double stranded RNA poly (rI).poly (rC), produce a chemotactic activity for granulocytes. The induction with IL 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e24635d790c1d522b9354e39788d58
https://doi.org/10.1016/1043-4666(90)90004-d
https://doi.org/10.1016/1043-4666(90)90004-d
Publikováno v:
International Journal of Experimental Pathology. 79:A29-A30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfd0e07c6c00cc4ceec21d719a92fbd5
https://doi.org/10.1046/j.1365-2613.1998.t01-20-750408.x
https://doi.org/10.1046/j.1365-2613.1998.t01-20-750408.x
Autor:
J. M. Seid, Rene Nordmann, R. Graveley, William Wishart, R. Graham G. Russell, S. Rahman, R.A.D. Bunning
Publikováno v:
Arthritis and rheumatism. 36(1)
OBJECTIVE To investigate the pattern of cytokine gene expression in human articular chondrocytes in culture in response to interleukin-1 beta (IL-1 beta). The effect of serum and variations in culture conditions was also studied. METHODS Messenger RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e021649dbdf2346e6101b008c276fa60
https://pubmed.ncbi.nlm.nih.gov/7678743
https://pubmed.ncbi.nlm.nih.gov/7678743
Autor:
S. Rahman, Karen Chapman, T.H. Jones, Pauline R.M. Dobson, Barry L. Brown, Roslin Russell, D.B. Evans, R.A.D. Bunning
Publikováno v:
Biochimica et biophysica acta. 1135(1)
The effect of bradykinin (BK) on proteinase activity, prostaglandin synthesis, and the production of interleukin-6 (IL-6) was investigated in cultures of human osteoblast-like cells. Bradykinin had no effect on stromelysin activity and plasminogen ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb16b46f417482c11bd69c4a51c8184f
https://pubmed.ncbi.nlm.nih.gov/1591276
https://pubmed.ncbi.nlm.nih.gov/1591276
Publikováno v:
Arthritis and rheumatism. 33(11)
The production of collagenase by human articular chondrocytes in response to interleukin-1 beta is inhibited in a dose-dependent manner by interferon-gamma (1-1,000 units/ml). The analysis of culture medium samples by Western blotting and the measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098d88e97af2502850c22baa6b5ca683
https://pubmed.ncbi.nlm.nih.gov/2173607
https://pubmed.ncbi.nlm.nih.gov/2173607
Publikováno v:
Biochemical and biophysical research communications. 166(3)
Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72ebbaffdde1acf26076ba0ec0d49a2
https://pubmed.ncbi.nlm.nih.gov/2407240
https://pubmed.ncbi.nlm.nih.gov/2407240
Publikováno v:
Biochemical and biophysical research communications. 166(1)
There is mounting evidence implicating cytokines such as interleukin-1 in the local regulation of bone homeostasis. In this report we show that recombinant human interleukin-1β (rhIL-1β) influences several activities of osteoblast-like cells derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c374052a6b665a7f8782a5830d0b17d
https://pubmed.ncbi.nlm.nih.gov/2302203
https://pubmed.ncbi.nlm.nih.gov/2302203